Aditya Sethi
@adityasethi.bsky.social
(he/him) Postdoc at the Genome Replication Lab at Institute of Cancer Research London https://costerlab.com/ | 🏳️🌈
Excited to share our review where we propose models for how DNA secondary structures destabilise the replication fork and lead to ssDNA gaps — it’s comprehensive but genuinely a thought-provoking piece. Hope it’s useful to the community.
@costerlab.bsky.social
www.sciencedirect.com/science/arti...
@costerlab.bsky.social
www.sciencedirect.com/science/arti...
How DNA secondary structures drive replication fork instability
DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…
www.sciencedirect.com
December 11, 2025 at 5:14 PM
Excited to share our review where we propose models for how DNA secondary structures destabilise the replication fork and lead to ssDNA gaps — it’s comprehensive but genuinely a thought-provoking piece. Hope it’s useful to the community.
@costerlab.bsky.social
www.sciencedirect.com/science/arti...
@costerlab.bsky.social
www.sciencedirect.com/science/arti...
Our review is out! A lot of hard work but completely worth it, especially with the best colleagues (and friends)! Hope you enjoy reading it
Our @costerlab.bsky.social review is out!
It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!
www.sciencedirect.com/science/arti...
@adityasethi.bsky.social @billiedelpino.bsky.social
It’s a great read on the impact of DNA secondary structures on eukaryotic replication fork progression - a totally unbiased opinion, of course!
www.sciencedirect.com/science/arti...
@adityasethi.bsky.social @billiedelpino.bsky.social
How DNA secondary structures drive replication fork instability
DNA secondary structures, such as hairpins, cruciforms, triplexes, G-quadruplexes and iMotifs, are common, dynamic features that replication forks rou…
www.sciencedirect.com
December 11, 2025 at 10:35 AM
Our review is out! A lot of hard work but completely worth it, especially with the best colleagues (and friends)! Hope you enjoy reading it
Reposted by Aditya Sethi
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science
https://go.nature.com/4kIRR01
https://go.nature.com/4kIRR01
Transparent peer review to be extended to all of Nature’s research papers
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science.
go.nature.com
June 16, 2025 at 4:44 PM
From today, all new submissions to Nature that are published will be accompanied by referees’ reports and author responses — to illuminate the process of producing rigorous science
https://go.nature.com/4kIRR01
https://go.nature.com/4kIRR01
Reposted by Aditya Sethi
New lab member joining is a great excuse to eat out and take a new lab photo 🎉🍜📷
June 12, 2025 at 2:28 PM
New lab member joining is a great excuse to eat out and take a new lab photo 🎉🍜📷
Caught pouting while discussing lab organization
May 7, 2025 at 10:40 AM
Caught pouting while discussing lab organization
April 1, 2025 at 10:59 AM
Reposted by Aditya Sethi
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
March 30, 2025 at 9:54 AM
📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
Reposted by Aditya Sethi
📷 New lab photos 😎
Still undecided as to which one is better... But we all look so happy 😏
Still undecided as to which one is better... But we all look so happy 😏
March 13, 2025 at 8:05 PM
📷 New lab photos 😎
Still undecided as to which one is better... But we all look so happy 😏
Still undecided as to which one is better... But we all look so happy 😏
First day of summer @icr.ac.uk and we're treating ourselves to working in the sun and eating Gelato!
March 20, 2025 at 5:19 PM
First day of summer @icr.ac.uk and we're treating ourselves to working in the sun and eating Gelato!
Reposted by Aditya Sethi
When you've been in the cell culture hood all day and finally get to take off your gloves:
March 6, 2025 at 8:21 PM
When you've been in the cell culture hood all day and finally get to take off your gloves:
I can't remember where I originally found this, but it makes me giggle every time I see it
February 20, 2025 at 4:31 PM
I can't remember where I originally found this, but it makes me giggle every time I see it
Reposted by Aditya Sethi
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability
Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.
tinyurl.com
February 19, 2025 at 7:35 PM
𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
Reading this great commentary from Michael Fischbach while trying to come up with ideas for projects! Highly recommend to new PhDs, Postdocs or PIs
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Problem choice and decision trees in science and engineering
Scientists and engineers often spend days choosing a problem and years solving it.
This imbalance limits impact. Here, we offer a framework for problem choice: prompts
for ideation, guidelines for eva...
www.cell.com
February 4, 2025 at 9:53 AM
Reading this great commentary from Michael Fischbach while trying to come up with ideas for projects! Highly recommend to new PhDs, Postdocs or PIs
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
😳😳😳
Not only does Bennu contain all 5 of the nucleobases that form DNA and RNA on Earth and 14 of the 20 amino acids found in known proteins, the asteroid’s amino acids hold a surprise
https://go.nature.com/4hDtGhL
https://go.nature.com/4hDtGhL
Asteroid fragments upend theory of how life on Earth bloomed
Samples from Bennu contain the chemical building blocks of life - but with a twist.
go.nature.com
January 30, 2025 at 9:54 AM
😳😳😳
Excited to have joined Gideon's lab at ICR, London! Looking forward to doing great science, making new friends and also the delicious lab lunches 🍲
🎉🔬 The lab has expanded! Today we celebrated the joining of Adi and Maria, two postdocs, with great Vietnamese food 🍽️
January 26, 2025 at 11:43 AM
Excited to have joined Gideon's lab at ICR, London! Looking forward to doing great science, making new friends and also the delicious lab lunches 🍲
Reposted by Aditya Sethi
The 90/10 rule of scientific discovery: 90% of your results come from 10% of your explorations, but it's not possible to know in advance what specific explorations those will be.
December 22, 2024 at 2:29 AM
The 90/10 rule of scientific discovery: 90% of your results come from 10% of your explorations, but it's not possible to know in advance what specific explorations those will be.
Reposted by Aditya Sethi
Exciting news!🌟 Together with Alexander van Oudenaarden, @jervdberg.bsky.social and @lleonie.bsky.social, we’ve been awarded a €2M NNF Synergy grant. We're thrilled to collaborate🤝 and to develop cutting-edge single-cell and single-molecule methods for replication and chromatin research! 🚀
December 20, 2024 at 12:19 PM
Exciting news!🌟 Together with Alexander van Oudenaarden, @jervdberg.bsky.social and @lleonie.bsky.social, we’ve been awarded a €2M NNF Synergy grant. We're thrilled to collaborate🤝 and to develop cutting-edge single-cell and single-molecule methods for replication and chromatin research! 🚀
Check out our recent work uncovering an unexpected role of the replicative helicase CMG in influencing cell fate decisions in vivo! We also show that it promotes differential expression of the highly conserved cell death gene egl-1 in cells fated to die!
Our researchers, in a paper just published in Nature Comms, offer new insights into how different #cell types are generated during animal development, which in future could help to solve some #autoimmunity, #cancer and #developmental abnormalities. doi.org/10.1038/s414... @uclofficial.bsky.social
December 12, 2024 at 10:50 AM
Check out our recent work uncovering an unexpected role of the replicative helicase CMG in influencing cell fate decisions in vivo! We also show that it promotes differential expression of the highly conserved cell death gene egl-1 in cells fated to die!
Check out the press release I wrote about our latest work on cell fate decisions in vivo! Our study has revealed that the highly conserved replicative helicase CMG promotes apoptotic fate & others such as neuronal or glial cell fate!
www.ucl.ac.uk/biosciences/...
@ucl-cdb.bsky.social
www.ucl.ac.uk/biosciences/...
@ucl-cdb.bsky.social
Making cell fate decisions during development - CDB researchers and collaborators gain new insight
Aditya Sethi, one of the co-authors of a paper just published in Nature Comms, explains how it offers new insights into how different cell types are generated during animal development, which in futur...
www.ucl.ac.uk
December 10, 2024 at 11:47 AM
Check out the press release I wrote about our latest work on cell fate decisions in vivo! Our study has revealed that the highly conserved replicative helicase CMG promotes apoptotic fate & others such as neuronal or glial cell fate!
www.ucl.ac.uk/biosciences/...
@ucl-cdb.bsky.social
www.ucl.ac.uk/biosciences/...
@ucl-cdb.bsky.social
Reposted by Aditya Sethi
We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.
Read more: nanoporetech.com/news/oxford-...
Read more: nanoporetech.com/news/oxford-...
November 27, 2024 at 9:16 AM
We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.
Read more: nanoporetech.com/news/oxford-...
Read more: nanoporetech.com/news/oxford-...
Reposted by Aditya Sethi
Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution.
www.nature.com/articles/d41...
www.nature.com/articles/d41...
November 20, 2024 at 5:07 PM
Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution.
www.nature.com/articles/d41...
www.nature.com/articles/d41...