This Review summarizes recent technical advancements in generative AI, outlines how new models might improve healthcare and discusses validation approaches—using lessons from recent successes and failures in the field.

An online joke reflects a sincere fear about how A.I. automation will upend the labor market and create a new norm of inequality.

Grow Your Own Cloud is a green biotech company developing regenerative data solutions through DNA data storage in Plants 🌱

Obtaining novel antibodies against specific protein targets is a widely important yet experimentally laborious process. Meanwhile, computational methods for antibody design have been limited by low su...

A small and fast diffusion model is presented, which is able to efficiently generate long protein backbones.

Biomining uses engineered microbes to harvest critical minerals

Deep learning methods trained on protein structure databases have revolutionized biomolecular structure prediction, but developing and training new models remains a considerable challenge. To facilita...

The recent surge in generative AI has introduced exciting possibilities for computational chemistry. Generative AI methods have made significant pr...

Researchers are increasingly turning to artificial-intelligence tools that can handle complex, multi-step processes.

Artificial intelligence is revolutionizing protein design by enabling precise navigation of sequence space and accelerating the creation of functional proteins. In this Review, a practical roadmap guides integration of artificial intelligence tools into design workflows, highlighting structural prediction, generative models and case studies spanning engineering therapeutic proteins to designing new ones.

This study describes a new method to enhance AlphaFold2 by integrating distance constraints, outperforming Rosetta and Alphafold on a test set of challenging protein targets. The method has potential applicability in modeling conformational states, fitting cryo-EM maps, and generating ensembles consistent with NMR data.

In vivo engineered T cells provide a promising approach to treat cardiac diseases

On September 16th, Biofabricate will open the doors to its two-day Biofab Fair in London. Suzanne Lee, Founder of the organization dedicated to...-materials

Acute-on-chronic liver failure (ACLF) is characterized by catastrophic loss of liver function in patients with advanced chronic liver disease, with 28-day mortality rates reaching up to 80%. Despite a...

In vivo chimeric antigen receptor (CAR)-T cell engineering uses targeted delivery systems to generate CAR-T cells directly in patients, bypassing ex vivo manufacturing. This Review examines emerging viral and lipid nanoparticle platforms, early clinical proof of concept and potential applications beyond cancer.

A new paper from Arc Institute shows that a generative AI model can be used to design viable bacteriophages.

Using SCN2A haploinsufficiency as a proof-of-concept, upregulation of the existing functional gene copy through CRISPR activation was able to rescue neurological-associated phenotypes in Scn2a haploinsufficient mice and human neurons.

Molecular machines hold great potential. Design of static monomeric and oligomeric protein structures has advanced tremendously, but few dynamic protein systems have been designed. Here we present the...

InterPLM is a computational framework to extract and analyze interpretable features from protein language models using sparse autoencoders. By training sparse autoencoders on ESM-2 embeddings, this study identifies thousands of interpretable biological features learned by the different layers of the ESM-2 model.

Genetic editing holds promise to treat incurable diseases, but the most popular method — CRISPR — sometimes does more harm than good. A new study from University of California San Diego and Yale Unive...

Microsoft researchers found a biological zero-day vulnerability — and created a software patch.

Researchers expose flaws in safeguards intended to block rogue actors from making bioweapons

A microchip-based DNA synthesis method enables scalable production of complex DNA constructs.