Thank you for posting!

🚨Please share! We are hiring a post-doc! 🪱 🐀
Job posting: www.training.nih.gov/jobs/pdf-gb-...
Lab Website: www.niddk.nih.gov/research-fun...
NIH Trainee info: www.training.nih.gov

Congrats David!! Excited to see what’s to come!

Here, through whole animal scRNA-seq, neuropeptidomics, and genetic screens awesome post-doc, Carrie Sheeler, answers those questions! Thank you collaborators @jennifergarrison.bsky.social 's lab and Kenyon lab!

I previously found that subtype of four astrocyte-like regulate organismal ER stress resistance and longevity.
science.org/doi/10.1126/...
However, the signal and full extent of the cell non-autonomous response remained unknown.

Excited to share another pre-print from our lab! We found a neuropeptide that can cell non-autonomously activate the ER-UPR and protect animals from proteotoxic stress.
www.biorxiv.org/content/10.1...

Congrats to Karmen Mah and Adam Roszczyk who figured out this initially puzzling observation! 🥳

· Mice with maternally inherited hGFAP-creERT2 exhibited no Cre-mediated recombination
· Recombination was robust in mice with paternally inherited hGFAP-creERT2
· Inheritance effect is NOT transgenerational
· Suppression of recombination was observed independent of colony.

A PSA for #astrocyte aficionados working with GFAP-CreERT2 mice from @jacksonlab.bsky.social (#012849)

Happy to share a recent pre-print from our lab!
Parental origin of transgene determines recombination efficiency in GFAP-CreERT2 mice
www.biorxiv.org/content/10.1...