@afrozec.bsky.social
Reposted
New preprint! We share a new *DNA-only* method for single-molecule DNA sequencing, and use this cool tool to link single-molecule reactions/interactions to sequence. Big thanks🙏 to Jagadish Hazra @becs-andrews.bsky.social and all contributors since our 2016 start!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Unraveling single-molecule reactions via multiplexed in-situ DNA sequencing
DNA sequence regulates complex reactions and protein-DNA interactions, yet sequence effects remain poorly understood due to the lack of direct, high-throughput approaches to study sequence-dependence ...
www.biorxiv.org
December 5, 2025 at 12:04 PM
New preprint! We share a new *DNA-only* method for single-molecule DNA sequencing, and use this cool tool to link single-molecule reactions/interactions to sequence. Big thanks🙏 to Jagadish Hazra @becs-andrews.bsky.social and all contributors since our 2016 start!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted
1/Now published! We identify a novel regulatory layer underlying SOS response dynamic. Find a short summary about our findings below.
journals.plos.org/plosbiology/...
#MicroSky
journals.plos.org/plosbiology/...
#MicroSky
Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction
The bacterial SOS response unfolds in a defined temporal order, but the determinants of this hierarchy are unclear. This study shows that intrinsic promoter strength, modulated in part by sigma factor...
journals.plos.org
December 10, 2025 at 1:46 PM
1/Now published! We identify a novel regulatory layer underlying SOS response dynamic. Find a short summary about our findings below.
journals.plos.org/plosbiology/...
#MicroSky
journals.plos.org/plosbiology/...
#MicroSky
Reposted
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
November 20, 2025 at 10:16 AM
Apply now to attend the next EMBO Bacterial Networks meeting #EMBOBacNet
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
🗓️13-18 September 2026
📍Sant Feliu de Guixols, Spain
📝Program and registration info: meetings.embo.org/event/26-bac...
👩🔬Organised with co-chair @s-lab.bsky.social and ECR @coralietesseur.bsky.social
#MicroSky
Reposted
Happy to share our most recent work www.pnas.org/doi/10.1073/.... Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!
Genome integrity relies on rapid recycling of DNA Pol III in bacteria | PNAS
DNA replication requires precise coordination between DNA unwinding and DNA synthesis.
In all domains of life, protein–protein interactions at the ...
www.pnas.org
November 20, 2025 at 4:54 PM
Happy to share our most recent work www.pnas.org/doi/10.1073/.... Here we describe how efficient DNA replication in E. coli is dependent on an interaction between SSB-ssDNA and the DNA polymerase (Pol III). Thanks to all the co-authors for their hard work!