@ahmad-ayadi.bsky.social
The malaria parasite relies on a protein called PfDdi1, a silent guardian that repairs its DNA to survive our medicine.
Artesunate now acts as a gentle key to lock this shield, turning the parasite’s own repair kit into a heavy, terminal burden.
👉 pubmed.ncbi.nlm.nih.gov/40113723/
Artesunate now acts as a gentle key to lock this shield, turning the parasite’s own repair kit into a heavy, terminal burden.
👉 pubmed.ncbi.nlm.nih.gov/40113723/
Computational Analysis of Plasmodium falciparum DNA Damage Inducible Protein 1 (PfDdi1): Insights into Binding of Artemisinin and its Derivatives and Implications for Antimalarial Drug Design - PubMed
Human malaria remains a global health challenge, with Plasmodium falciparum responsible for the most severe cases. Despite global efforts, eradicating malaria has proven difficult, mainly because of the rise in drug resistance, particularly against artemisinin and its derivatives. One possible cause …
pubmed.ncbi.nlm.nih.gov
January 14, 2026 at 10:04 AM
The malaria parasite relies on a protein called PfDdi1, a silent guardian that repairs its DNA to survive our medicine.
Artesunate now acts as a gentle key to lock this shield, turning the parasite’s own repair kit into a heavy, terminal burden.
👉 pubmed.ncbi.nlm.nih.gov/40113723/
Artesunate now acts as a gentle key to lock this shield, turning the parasite’s own repair kit into a heavy, terminal burden.
👉 pubmed.ncbi.nlm.nih.gov/40113723/
🧬The Rhythm of Restoration🎼
When cancer breaks the cell’s quiet rhythm of repair, it leaves behind a hidden path of genomic instability. Tiny molecules now turn these flaws into a clever trap, healing the body with the gentle precision of nature.
👉 pubmed.ncbi.nlm.nih.gov/41190241/
When cancer breaks the cell’s quiet rhythm of repair, it leaves behind a hidden path of genomic instability. Tiny molecules now turn these flaws into a clever trap, healing the body with the gentle precision of nature.
👉 pubmed.ncbi.nlm.nih.gov/41190241/
Targeting DNA repair mechanisms in cancer therapy: the role of small molecule DNA repair inhibitors - PubMed
Genomic instability and the accumulation of DNA damage are hallmarks of cancer, often resulting from defects in DNA repair pathways. While normal cells rely on highly coordinated DNA damage response (DDR) mechanisms to maintain genomic integrity, cancer cells exploit aberrant DDR regulation to susta …
pubmed.ncbi.nlm.nih.gov
January 13, 2026 at 3:44 PM
🧬The Rhythm of Restoration🎼
When cancer breaks the cell’s quiet rhythm of repair, it leaves behind a hidden path of genomic instability. Tiny molecules now turn these flaws into a clever trap, healing the body with the gentle precision of nature.
👉 pubmed.ncbi.nlm.nih.gov/41190241/
When cancer breaks the cell’s quiet rhythm of repair, it leaves behind a hidden path of genomic instability. Tiny molecules now turn these flaws into a clever trap, healing the body with the gentle precision of nature.
👉 pubmed.ncbi.nlm.nih.gov/41190241/
🧬Chromatin / DDR co-mutations drive high-TMB in SMARCA4-DNSCLC, enabling immunotherapy success despite PD-L1 negativity. Tailored precision therapy yielded a 15-month survival, doubling the typical prognosis.
Study: doi.org/10.3389/fonc...
Study: doi.org/10.3389/fonc...
Frontiers | Case Report: SMARCA4-deficient NSCLC with brain metastasis harboring co-mutations in chromatin remodeling and DNA damage repair pathways
SMARCA4 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) is the core ATPase subunit of SWI/SNF chromatin remod...
doi.org
January 12, 2026 at 8:47 AM
🧬Chromatin / DDR co-mutations drive high-TMB in SMARCA4-DNSCLC, enabling immunotherapy success despite PD-L1 negativity. Tailored precision therapy yielded a 15-month survival, doubling the typical prognosis.
Study: doi.org/10.3389/fonc...
Study: doi.org/10.3389/fonc...
🔬Limiting just one amino acid, methionine, allows our body to gently mend the delicate genetic blueprint of our life. It awakens protectors in the brain while easing the liver's toil, creating a quiet harmony that shields us from time.
pubmed.ncbi.nlm.nih.gov/40723841/
pubmed.ncbi.nlm.nih.gov/40723841/
Methionine Restriction Differentially Modulates Expression of Genes in the Base Excision Repair Pathway in Rat Brain and Liver - PubMed
Methionine restriction (MetR) is a dietary intervention that extends mean and maximum life span in rodents, at least in part, by reducing oxidative stress and promoting DNA stability in different tissues. Regarding DNA stability, DNA repair pathways play a critical role, both in the nuclear and mito …
pubmed.ncbi.nlm.nih.gov
January 11, 2026 at 10:04 AM
🔬Limiting just one amino acid, methionine, allows our body to gently mend the delicate genetic blueprint of our life. It awakens protectors in the brain while easing the liver's toil, creating a quiet harmony that shields us from time.
pubmed.ncbi.nlm.nih.gov/40723841/
pubmed.ncbi.nlm.nih.gov/40723841/
HELLS shields cancer DNA by remodeling chromatin.
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨
academic.oup.com/nar/article/...
#DNADamage, #DNARepair
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨
academic.oup.com/nar/article/...
#DNADamage, #DNARepair
The chromatin regulator HELLS mediates SSB repair and responses to DNA alkylation damage
Abstract. The SNF2 family chromatin remodeler HELLS has emerged as an important regulator of cell proliferation, genome stability, and several cancer pathw
academic.oup.com
January 10, 2026 at 11:15 AM
HELLS shields cancer DNA by remodeling chromatin.
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨
academic.oup.com/nar/article/...
#DNADamage, #DNARepair
Its protection hides a vulnerability: removing HELLS triggers genomic chaos. 🧬✨
academic.oup.com/nar/article/...
#DNADamage, #DNARepair
🎯Targeting LIPT1 triggers a 2HG surge that acts as an epigenetic mask to hide DNA damage. This paralyzes TIP60-ATM signaling and homologous recombination, leaving tumors defenseless against radiation.
Full Study: www.science.org/doi/10.1126/...
Full Study: www.science.org/doi/10.1126/...
Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair
Genetic screen finds lipoylation as a target to improve radiation success in lung cancer by blocking DNA damage repair.
www.science.org
January 9, 2026 at 10:16 AM
🎯Targeting LIPT1 triggers a 2HG surge that acts as an epigenetic mask to hide DNA damage. This paralyzes TIP60-ATM signaling and homologous recombination, leaving tumors defenseless against radiation.
Full Study: www.science.org/doi/10.1126/...
Full Study: www.science.org/doi/10.1126/...
🧬🧫While healthy stem cells work to mend us, cancer stem cells hijack that healing to build fortresses of resistance. By unmasking their hidden genetic maps, we can finally target the illness while keeping our body's natural healers safe.
pubmed.ncbi.nlm.nih.gov/40868290/
pubmed.ncbi.nlm.nih.gov/40868290/
Transcriptomic Comparisons of Somatic and Cancer Stem Cells - PubMed
Stem cells are essential for tissue maintenance, repair, and regeneration, yet their dysregulation gives rise to cancer stem cells (CSCs), which drive tumor progression, metastasis, and therapy resistance. Despite extensive research on stemness and oncogenesis, a critical gap remains in our understa …
pubmed.ncbi.nlm.nih.gov
January 8, 2026 at 6:02 PM
🧬🧫While healthy stem cells work to mend us, cancer stem cells hijack that healing to build fortresses of resistance. By unmasking their hidden genetic maps, we can finally target the illness while keeping our body's natural healers safe.
pubmed.ncbi.nlm.nih.gov/40868290/
pubmed.ncbi.nlm.nih.gov/40868290/