banner
aizepellon.bsky.social
Aize Pellón Rodríguez
@aizepellon.bsky.social
1.3K followers 500 following 49 posts
#MSCA Postdoctoral Fellow at CIC bioGUNE (Bilbao, Spain) || Host-microbe interactions || Fungal Immunology || Innate immune memory || Trained immunity || Immunometabolism || Microbiota #SinCienciaNoHayFuturo #MycoSky https://linktr.ee/aizepellonrodriguez
linktr.ee
Posts Media Videos Starter Packs
Pinned
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · Jan 10
📃Friday publication alert!

Our latest review paper
"Friends to remember: innate immune memory regulation by the microbiota" Trends in Microbiology @cp-trendsmicrobiol.bsky.social

Brief paper tutorial below 👇

@anguitalab.bsky.social @cicbiogune.bsky.social
www.sciencedirect.com/science/arti...
Friends to remember: innate immune memory regulation by the microbiota
Innate immune memory (IIM) is the process by which, upon a primary challenge, innate immune cells alter their epigenetic, transcriptional, and immunom…
www.sciencedirect.com
1 5 10
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · 6d
Kudos to all co-authors and collaborators! Especially to Sam Pasco and Juan Anguita for leading this project.

@cicbiogune.bsky.social @neikerbrta.bsky.social

🧵6/6
1
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · 6d
🔚 Bottom line:
SAS induces a context-dependent innate immune memory that enhances protection but is reversible.
This opens doors to smarter vaccine design using adjuvants as immune trainers.

Read the full paper 👉 doi.org/10.1111/imm....
#Vaccines #TrainedImmunity
🧵5/6
Challenge Specific Modulation of Responses to Adjuvant‐Induced Innate Immune Memory
We utilised a commercially available adjuvant formulation to study the induction, maintenance, and consequences of innate immune memory. Using functional assays on bone marrow-derived innate cells, e...
doi.org
1
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · 6d
📊 Bone marrow single-cell transcriptomic (scRNAseq) analyses revealed:

-Upregulation of immune genes (e.g. Elane, Gzmb, Fc receptors)
-Downregulation of epigenetic regulators and metabolic genes
→ A shift toward immune activation and metabolic rewiring.
#RNAseq #Immunometabolism

🧵4/6
1
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · 6d
🧬 SAS-trained mice showed:

-Reduced proinflammatory TNF production by macrophages
-Increased circulating monocytes and altered HSPC population dynamics
-Enhanced neutrophil antimicrobial activity

This suggests functional reprogramming of innate cells.
#Macrophages #Neutrophils

🧵3/6
1
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · 6d
💉 We used the Sigma Adjuvant System (SAS), which contains MPLA (TLR4 agonist) and TDCM (MINCLE agonist).
We treated mice and tracked long-term changes in bone marrow hematopoietic stem and progenitor cells (HSPCs).

Result: SAS shifted HSPC populations toward myeloid-biased progenitors.

🧵2/6
1
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · 6d
🚨 New paper alert!

Our team at CIC bioGUNE has just published a new study in "Immunology" exploring how adjuvants can induce innate immune memory and reshape hematopoiesis.

Let’s dive in 👇

#InnateMemory #TrainedImmunity #Immunology
@anguitalab.bsky.social @cicbiogune.bsky.social

🧵1/6
1 2 4
Reposted by Aize Pellón Rodríguez
braithwaiteat.bsky.social
Adam Braithwaite @braithwaiteat.bsky.social · Jul 3
Stimulating immune cells in vitro is a common experimental lab model. We profiled 150K blood immune cells treated with 11 different stimuli to compare the effects. The data are freely available for researchers. See the preprint for our findings and to access the data 🧪 doi.org/10.1101/2025...
10 42 130
Reposted by Aize Pellón Rodríguez
therad-lab.bsky.social
Rebecca Drummond 🍄 @therad-lab.bsky.social · Aug 14
Very excited to announce launch of brand new journal npj Fungal Science! As EIC I'm joined by a fantastic board of academic editors from across the mycology field. You can learn more about the journal scope and submit your work here: www.nature.com/npjfungalsci/
npj Fungal Science
TBC
www.nature.com
13 31
Reposted by Aize Pellón Rodríguez
vdlorenzo.bsky.social
Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · Aug 12
Spain is on fire. Italy, Greece, Portugal — all burning. We have had summer fires before, but never like this. This is climate breakdown in real time. It is killing people, animals, and our future. DAMN the climate deniers. DAMN those who know and could do but do NOTHING www.bbc.com/news/article...
Wildfires rage across southern Europe as temperatures pass 40C
The heatwave has led to red alerts being issued in parts of Italy, France, Spain, Portugal and the Balkans.
www.bbc.com
3 24 40
Reposted by Aize Pellón Rodríguez
davidalbesa.bsky.social
David Albesa @davidalbesa.bsky.social · Aug 7
📢 Job alert! The Structural Microbiology Laboratory (albesalab.org) has two new openings! We are looking for a PhD student and a Research Technician to join our team.

Project: "Structure-function studies of Type VI secretion system toxins".

www.biofisika.org/en/join-us

Apply before 30th September
Albesa Lab – Structural Microbiology Laboratory
albesalab.org
7 3
Reposted by Aize Pellón Rodríguez
neil-gow.bsky.social
Neil Gow @neil-gow.bsky.social · Aug 7
New work from the Prasad lab showing that Candida auris can become amphotericin resistant either by multiple, sterol dependent and sterol independent mechanisms. dx.doi.org/10.1111/mmi..... @mrccmm.bsky.social @youngecmm.bsky.social @ishamycology.bsky.social @bsmm-meeting.bsky.social
1 6 13
Reposted by Aize Pellón Rodríguez
magdalenaskipper.bsky.social
Magdalena Skipper @magdalenaskipper.bsky.social · Aug 2
This is fascinating - the brain fires up immune cells when sick people are nearby
🧪

www.nature.com/articles/d41...
The brain fires up immune cells when sick people are nearby
When people viewed virtual avatars with coughs or rashes, their brains triggered an immune response.
www.nature.com
8 31 120
Reposted by Aize Pellón Rodríguez
pasteuredu.bsky.social
Institut Pasteur Education @pasteuredu.bsky.social · Aug 1
🖥️ The MOOC “Medical Mycology” is open for registration!   
👉 bit.ly/medical-myco...
🍄 Welcome to the fascinating world of fungi, agents of major infectious diseases! Discover the taxonomy, ecology, identification of fungi, epidemiology of infectious diseases, drugs, link with HIV…Share this info!
Medical Mycology
Welcome to the fascinating world of fungi, agents of major infectious diseases!
bit.ly
9 14
Reposted by Aize Pellón Rodríguez
rbgkew.bsky.social
Kew Gardens @rbgkew.bsky.social · Jul 25
This #FungiFriday marks the opening of Kew’s new #CarbonGarden! With its big mushroom centrepiece, we thought we would dig into Fungi’s indispensable role in carbon storage; through nutrient cycling, soil formation, and as symbionts with plants 🍄🍄🟫
Carbon Garden at Kew. Featuring a structured shaped like a fungi
2 13 64
Reposted by Aize Pellón Rodríguez
sancholab.bsky.social
David Sancho @sancholab.bsky.social · Jul 16
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
4 17 43
Reposted by Aize Pellón Rodríguez
cicbiogune.bsky.social
CIC bioGUNE @cicbiogune.bsky.social · Jul 3
#bioGUNE_Jobs |🧬 #CICbioGUNE seeks postdocs for
#MSCActions @ec.europa.eu PF 2025!

Ready to boost your career in cutting-edge biomedical research?

📅 Deadline: September, 10th
📽️ Hear from our 2024 fellows in new videos
youtube.com/shorts/YHGxz...
Historias Marie Curie - Aize Pellón Rodríguez
YouTube video by CIC bioGUNE
youtube.com
1 1
Reposted by Aize Pellón Rodríguez
kamounlab.bsky.social
Sophien Kamoun @kamounlab.bsky.social · Jul 11
I just published: Why I’m skipping the Congress this year (And why you should still publish your posters)

Publishing your poster creates a citable record and protects you from bad actors.

#ISMPMI2025 #OpenMPMI #AcademicChatter #PhDchat

medium.com/p/why-im-ski...
Why I’m skipping the Congress this year (And why you should still publish your posters)
Publishing your poster creates a verifiable and citable record of your work. It also protects you from bad actors — the evidence will be…
medium.com
9 25 52
Reposted by Aize Pellón Rodríguez
cicbiogune.bsky.social
CIC bioGUNE @cicbiogune.bsky.social · May 22
#bioGUNE_Outreach | #CICbioGUNE @brtaeus.bsky.social participó en @pintofscience.es #Bilbao los días 19, 20 y 21 de mayo

@aizepellon.bsky.social y Edurne Berra acercaron su investigación sobre inmunidad, microbiota e hipoxia en un entorno cercano y divulgativo

🔗 ow.ly/WrUk50VWUhj
1 2 4
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · May 22
Muchas gracias a la organización del evento, a Hika Ateneo por el espacio, y a todas aquellas personas que se acercaron a conocer un poco más nuestros proyectos de investigación. ¡Espero que disfrutaran y aprendieran tanto como yo!

¡Nos vemos el año que viene en los bares!

#PINT25ES #PINT25BIO
1 3
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · May 22
El lunes tuve el placer de participar en @pintofscience.es, festival de ciencia internacional y su X edición en España, con mi charla "Amigos para recordar: memoria innata y microbiota". ¡Fue una gran experiencia!

@cicbiogune.bsky.social @anguitalab.bsky.social

#PINT25ES #PINT25BIO
1 1 4
Reposted by Aize Pellón Rodríguez
mikeliturriaga.bsky.social
Mikel López Iturriaga @mikeliturriaga.bsky.social · May 15
Gentes de Bluesky, firmad esto que es importante: iniciativa ciudadana europea para prohibir las "terapias" de conversión de personas LGTBIQ+. NO es un change.org, puede suponer un cambio legal real. Y no lo dejéis para luego, que se acaba el sábado. eci.ec.europa.eu/043/public/#...
European Citizens' Initiative
Give your support !
eci.ec.europa.eu
170 1.7K 1.9K
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · May 14
Esta charla se enmarca dentro de "Pint of Science", un festival internacional de divulgación científica en el que me hace mucha ilusión participar, especialmente siendo el décimo aniversario. ¡Gracias @pintofscience.es y al equipo organizador de Bilbo por la oportunidad!

#PINT25BIO #PINT25ES
1 1
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · May 14
El próximo lunes 19 a las 7:00pm estaré en Hika Ateneo (Bilbo) charlando sobre la investigación realizada en nuestro laboratorio para entender la comunicación entre nuestro sistema inmunitario y la microbiota (microbios que habitan nuestro cuerpo) 👇

@pintofscience.es #PINT25BIO #PINT25ES
cicbiogune.bsky.social
CIC bioGUNE @cicbiogune.bsky.social · May 14
#bioGUNE_Outreach | ¡La ciencia sale a la calle!

Este lunes 19 de mayo, Edurne Berra y @aizepellon.bsky.social participarán en el evento #PINT25BIO dentro del festival internacional @pintofscience.es

📍 Hika Ateneo, Bilbao
🗓️ 19 de mayo

¡Te esperamos!
🔗 pintofscience.es/events/bilbao
1 1 3
aizepellon.bsky.social
Aize Pellón Rodríguez @aizepellon.bsky.social · May 13
Our review paper "Friends to remember: innate immune memory regulation by the microbiota" is now live in the May issue of Trends in Microbiology. See the link below! 👇

@anguitalab.bsky.social @cicbiogune.bsky.social @upvehu.bsky.social @cp-trendsmicrobiol.bsky.social
cp-trendsmicrobiol.bsky.social
Trends in Microbiology @cp-trendsmicrobiol.bsky.social · May 13
The May issue is live now! Cover image showing plasmid and phage transmission trade-offs.

As part of our series on geographical inclusion, in this issue, we look at expanding microbiome sciences in the Caribbean and the need for Africa-focused microbiome initiatives.

www.cell.com/issue/S0966-...
1 9
Reposted by Aize Pellón Rodríguez
cp-trendsmicrobiol.bsky.social
Trends in Microbiology @cp-trendsmicrobiol.bsky.social · May 13
The May issue is live now! Cover image showing plasmid and phage transmission trade-offs.

As part of our series on geographical inclusion, in this issue, we look at expanding microbiome sciences in the Caribbean and the need for Africa-focused microbiome initiatives.

www.cell.com/issue/S0966-...
1 1 6