David Sancho
@sancholab.bsky.social
Passionate about #immunology. Sensing damaged self, infections & microbiota by DCs and macrophages to ignite innate & adaptive immunity. #Immunometabolism
Professor of Immunology @CNIC, Madrid, Spain. https://www.cnic.es/en/investigacion/immunobiology
Professor of Immunology @CNIC, Madrid, Spain. https://www.cnic.es/en/investigacion/immunobiology
Pinned
David Sancho
@sancholab.bsky.social
· Jul 16
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Reposted by David Sancho
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
(1/9)
www.embopress.org/doi/full/10....
(1/9)
Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal
imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital
parameters within physiological ranges. This study characterizes how mouse monocyte-derived
macrophages...
www.embopress.org
November 19, 2025 at 2:11 PM
🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
(1/9)
www.embopress.org/doi/full/10....
(1/9)
Reposted by David Sancho
🌞 Day 2 begins at La Cristalera!
Today we welcome 2 Invited Plenary Speakers:
🔶 Prof. David Sancho, @sancholab.bsky.social (CNIC)
🔶 Prof. Susana Guerrero Salazar (University of Málaga)
✨Another full day of science, ideas, and inspiring talks ahead!
#RetreatIIBM_2025 #IIBmCSICUAM
@csic.es @uam.es
Today we welcome 2 Invited Plenary Speakers:
🔶 Prof. David Sancho, @sancholab.bsky.social (CNIC)
🔶 Prof. Susana Guerrero Salazar (University of Málaga)
✨Another full day of science, ideas, and inspiring talks ahead!
#RetreatIIBM_2025 #IIBmCSICUAM
@csic.es @uam.es
November 8, 2025 at 5:55 PM
🌞 Day 2 begins at La Cristalera!
Today we welcome 2 Invited Plenary Speakers:
🔶 Prof. David Sancho, @sancholab.bsky.social (CNIC)
🔶 Prof. Susana Guerrero Salazar (University of Málaga)
✨Another full day of science, ideas, and inspiring talks ahead!
#RetreatIIBM_2025 #IIBmCSICUAM
@csic.es @uam.es
Today we welcome 2 Invited Plenary Speakers:
🔶 Prof. David Sancho, @sancholab.bsky.social (CNIC)
🔶 Prof. Susana Guerrero Salazar (University of Málaga)
✨Another full day of science, ideas, and inspiring talks ahead!
#RetreatIIBM_2025 #IIBmCSICUAM
@csic.es @uam.es
Gracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación.
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...
También apoyo fundamental en: www.nature.com/articles/s41...
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...
También apoyo fundamental en: www.nature.com/articles/s41...
July 25, 2025 at 9:32 AM
Gracias @caixaresearch.bsky.social por el sólido apoyo a nuestra investigación.
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...
También apoyo fundamental en: www.nature.com/articles/s41...
Este reporte es sobre las cDC1s en la generación de respuesta adaptativa en #atherosclerosis & #immunotherapy en el hilo www.ahajournals.org/doi/10.1161/...
También apoyo fundamental en: www.nature.com/articles/s41...
Reposted by David Sancho
This work identifies 'imidazole propionate' as a causal microbial metabolite that promotes atherosclerosis and shows that modulating its levels can potentially prevent cardiovascular disease risk, a promising therapeutic strategy.👇
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
July 23, 2025 at 4:51 PM
This work identifies 'imidazole propionate' as a causal microbial metabolite that promotes atherosclerosis and shows that modulating its levels can potentially prevent cardiovascular disease risk, a promising therapeutic strategy.👇
A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment|ERC erc.europa.eu/news-events/...
A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment
A new study led by the Spanish National Centre for Cardiovascular Research (CNIC) and funded by the European Reasearch Council (ERC) has identified imidazole propionate (ImP), a metabolite produced by...
erc.europa.eu
July 19, 2025 at 9:09 AM
A gut microbiota metabolite linked to atherosclerosis could revolutionise diagnosis and treatment|ERC erc.europa.eu/news-events/...
Fantástico resumen por @manuelansede.bsky.social
🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón €
🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab
🙏 @erc.europa.eu ERC-CoG ERC-POC
#CNIC_CARDIO
Open acess: www.nature.com/articles/s41...
🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón €
🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab
🙏 @erc.europa.eu ERC-CoG ERC-POC
#CNIC_CARDIO
Open acess: www.nature.com/articles/s41...
July 17, 2025 at 3:11 PM
Fantástico resumen por @manuelansede.bsky.social
🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón €
🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab
🙏 @erc.europa.eu ERC-CoG ERC-POC
#CNIC_CARDIO
Open acess: www.nature.com/articles/s41...
🙏 @caixaresearch.bsky.social por financiar proyecto con 1 millón €
🙏 @ageinves.bsky.social por Severo Ochoa que inició el proyecto + 100K€ a nuestro lab
🙏 @erc.europa.eu ERC-CoG ERC-POC
#CNIC_CARDIO
Open acess: www.nature.com/articles/s41...
Reposted by David Sancho
Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @sancholab.bsky.social, se acaba de publicar en la revista @nature.com 👇
elpais.com/salud-y-bien...
elpais.com/salud-y-bien...
Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes
El descubrimiento, gracias a un experimento con cientos de trabajadores del Banco Santander en Madrid, abre la puerta a nuevos tratamientos más allá de reducir el colesterol
elpais.com
July 16, 2025 at 8:33 PM
Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @sancholab.bsky.social, se acaba de publicar en la revista @nature.com 👇
elpais.com/salud-y-bien...
elpais.com/salud-y-bien...
Reposted by David Sancho
Esta investigación del CNIC revela que un metabolito de la microbiota intestinal favorece la aterosclerosis.
Descubre más de la mano de uno de los investigadores del equipo 👇🧬
Descubre más de la mano de uno de los investigadores del equipo 👇🧬
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
July 17, 2025 at 10:37 AM
Esta investigación del CNIC revela que un metabolito de la microbiota intestinal favorece la aterosclerosis.
Descubre más de la mano de uno de los investigadores del equipo 👇🧬
Descubre más de la mano de uno de los investigadores del equipo 👇🧬
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Imidazole propionate is a driver and therapeutic target in atherosclerosis - Nature
Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 ...
nature.com
July 16, 2025 at 5:37 PM
💥 A gut microbe metabolite that drives #atherosclerosis?
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Yes—Imidazole propionate (ImP) triggers vascular inflammation without changing cholesterol.
🧪 We show the pathway—and how to block it.
nature.com/articles/s41... #OpenAccess at
@Nature
@CNIC_CARDIO
#CVD #immunosky #cardiosky #microbiomesky
Reposted by David Sancho
Thank you to my co-author @iroblesv.bsky.social and
@sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!
@sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!
July 16, 2025 at 4:52 PM
Thank you to my co-author @iroblesv.bsky.social and
@sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!
@sancholab.bsky.social for believing in this project and to all the researchers who contributed to this work!!
Congrats @iannaconelab.bsky.social & team on a wonderful work @natimmunol.nature.com on the immune regulation in the liver: CD4+ T cells license Kupffer cells to rescue CD8+ T cells through IL12 & mainly IL27. Highly relevant for liver immunotherapy!!!
👏🏻👏🏻👏🏻👏🏻👏🏻
#immunosky
👇🏻👇🏻👇🏻
👏🏻👏🏻👏🏻👏🏻👏🏻
#immunosky
👇🏻👇🏻👇🏻
1/ 🚨 Hot off the press in Nature Immunology: CD4⁺ T cells can license Kupffer cells to rescue dysfunctional CD8⁺ T cells in the liver. Hepatitis B virus (HBV) infection is just the proving ground—this is a paradigm shift in tissue immunity. www.nature.com/articles/s41... 🧵(1/11)
July 1, 2025 at 6:06 AM
Congrats @iannaconelab.bsky.social & team on a wonderful work @natimmunol.nature.com on the immune regulation in the liver: CD4+ T cells license Kupffer cells to rescue CD8+ T cells through IL12 & mainly IL27. Highly relevant for liver immunotherapy!!!
👏🏻👏🏻👏🏻👏🏻👏🏻
#immunosky
👇🏻👇🏻👇🏻
👏🏻👏🏻👏🏻👏🏻👏🏻
#immunosky
👇🏻👇🏻👇🏻
🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
June 22, 2025 at 5:42 PM
🧬 New immunotherapy for atherosclerosis @ahajournals.bsky.social #CircRes
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Type 1 dendritic cells (cDC1s) promote atherogenic immunity & can be targeted with tolerogenic nanoparticles.
🔗 doi.org/10.1161/CIRC...
#Immunotherapy #Atherosclerosis #Nanomedicine
#CNIC_CARDIO #immunosky #cardiosky
Congrats Irene Adán-Barrientos: great thesis presentation & defense at CNIC & @uam.es
Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit!
Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!
Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit!
Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!
June 17, 2025 at 1:30 PM
Congrats Irene Adán-Barrientos: great thesis presentation & defense at CNIC & @uam.es
Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit!
Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!
Thx thesis commitee: Julián Aragonés, Arantxa Cruz-Adalia & Bart Everts on wonderful discussion and visit!
Thx Gillian Dunphy @gilliandunphy.bsky.social on fantastic co-supervision!!!
Reposted by David Sancho
A type of immune system cell boosts #immunotherapy and prevents #cancer relapse in animal models.
✍️ @ignaciohm.bsky.social @swculek.bsky.social @sancholab.bsky.social et al.
📰 @naturecomms.bsky.social
➡️ https://shorturl.at/DaPr3
📌DOI: 10.1038/s41467-025-58289-1. PMID: 40204706
🧪
✍️ @ignaciohm.bsky.social @swculek.bsky.social @sancholab.bsky.social et al.
📰 @naturecomms.bsky.social
➡️ https://shorturl.at/DaPr3
📌DOI: 10.1038/s41467-025-58289-1. PMID: 40204706
🧪
April 29, 2025 at 9:02 AM
A type of immune system cell boosts #immunotherapy and prevents #cancer relapse in animal models.
✍️ @ignaciohm.bsky.social @swculek.bsky.social @sancholab.bsky.social et al.
📰 @naturecomms.bsky.social
➡️ https://shorturl.at/DaPr3
📌DOI: 10.1038/s41467-025-58289-1. PMID: 40204706
🧪
✍️ @ignaciohm.bsky.social @swculek.bsky.social @sancholab.bsky.social et al.
📰 @naturecomms.bsky.social
➡️ https://shorturl.at/DaPr3
📌DOI: 10.1038/s41467-025-58289-1. PMID: 40204706
🧪
Reposted by David Sancho
This week the world gained another Doctor of Immunology, and we are all the richer for it! Congratulations Dr. Irene on a great thesis and defense. Thank you to the examiners for the interesting discusion and to @sancholab.bsky.social for cosupervising with me these years - it has been a pleasure!
June 6, 2025 at 12:56 PM
This week the world gained another Doctor of Immunology, and we are all the richer for it! Congratulations Dr. Irene on a great thesis and defense. Thank you to the examiners for the interesting discusion and to @sancholab.bsky.social for cosupervising with me these years - it has been a pleasure!
Reposted by David Sancho
Heras-Murillo et al. treated mice with tumor cell lysate-loaded syngeneic splenic selected cDC populations. bit.ly/4cKkXJp @sancholab.bsky.social
April 28, 2025 at 11:30 AM
Heras-Murillo et al. treated mice with tumor cell lysate-loaded syngeneic splenic selected cDC populations. bit.ly/4cKkXJp @sancholab.bsky.social
Reposted by David Sancho
Great talk by @sancholab.bsky.social shedding light on the role of #dendriticcells in #atherosclerosis: players in shaping immune responses within plaques. #ImmunoAthero
April 23, 2025 at 8:39 AM
Great talk by @sancholab.bsky.social shedding light on the role of #dendriticcells in #atherosclerosis: players in shaping immune responses within plaques. #ImmunoAthero
Put a dendritic cell (DC) in your tumor #immunotherapy!
cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social
www.nature.com/articles/s41...
#immunosky #cancersky (1/7)
cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social
www.nature.com/articles/s41...
#immunosky #cancersky (1/7)
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...
www.nature.com
April 15, 2025 at 6:05 PM
Put a dendritic cell (DC) in your tumor #immunotherapy!
cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social
www.nature.com/articles/s41...
#immunosky #cancersky (1/7)
cDC1-based vaccines induce strong effector & memory anti-tumor T cell response. Improved immune memory prevents tumor relapse! #CNIC @ageinves.bsky.social @contracancerinv.bsky.social
www.nature.com/articles/s41...
#immunosky #cancersky (1/7)
Reposted by David Sancho
Immunotherapy with cDC1 induces immune memory and limits tumor relapse @naturecomms.bsky.social @sancholab.bsky.social @swculek.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 10, 2025 at 5:38 PM
Immunotherapy with cDC1 induces immune memory and limits tumor relapse @naturecomms.bsky.social @sancholab.bsky.social @swculek.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Sancho
Kudos to @sancholab.bsky.social and @swculek.bsky.social for this work in @naturecomms.bsky.social showing that "that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immunotherapy with conventional type-1 dendritic cells induces immune memory and limits tumor relapse - Nature Communications
Dendritic cells (DCs) induce infection-protective immune memory, which has yet to be exploited for cancer therapy. Here we show that type 1 DC vaccines quantitatively and qualitatively favors anti-tum...
www.nature.com
April 10, 2025 at 2:48 PM
Kudos to @sancholab.bsky.social and @swculek.bsky.social for this work in @naturecomms.bsky.social showing that "that cDC1-based vaccination excels at immune memory induction and prevention of cancer recurrence"
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by David Sancho
And it gives me the chance the highlight the best CD4+ T cell/ice cream crossover review:
doi.org/10.1038/s415...
doi.org/10.1038/s415...
A fresh look at the T helper subset dogma - Nature Immunology
Single-cell-sequencing techniques enable the decades-old T helper subset dogma to be re-examined in an unsupervised manner, bringing nuance to the definition of known subsets while simultaneously iden...
doi.org
March 24, 2025 at 5:33 PM
And it gives me the chance the highlight the best CD4+ T cell/ice cream crossover review:
doi.org/10.1038/s415...
doi.org/10.1038/s415...
Reposted by David Sancho
Stanley Huang told us about metabolic regulation of macrophages and Roser Vento gave us a great talk on spatial analysis of macrophages in reproductive tissues! What an amazing end of session. #EPW2025 #immunosky
March 29, 2025 at 10:02 PM
Stanley Huang told us about metabolic regulation of macrophages and Roser Vento gave us a great talk on spatial analysis of macrophages in reproductive tissues! What an amazing end of session. #EPW2025 #immunosky
Reposted by David Sancho
I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!
@adrover.bsky.social rocking on a fantastic new and vascular-damaging Ly6Clo neutrophils, he will now investigate deeper in his #brandnewlab #EPW2025
March 30, 2025 at 10:48 AM
I had a wonderful time! Great conference and speakers! Thanks @casanova-acebes.bsky.social @sancholab.bsky.social and Carlos Silvestre for the great work organizing such an amazing meeting!
Reposted by David Sancho
#ElodieSegura investigating cellular and molecular changes of in monocytes upon AhR signaling at #EPW2025
March 28, 2025 at 1:55 PM
#ElodieSegura investigating cellular and molecular changes of in monocytes upon AhR signaling at #EPW2025
Reposted by David Sancho
Kati Mauel from our lab talking about splenic #macrophages and their response to #malaria infection at #EPW2025 🤩
Full house at #EPW2925 in #phagocyte in motion session!
March 27, 2025 at 2:15 PM
Kati Mauel from our lab talking about splenic #macrophages and their response to #malaria infection at #EPW2025 🤩