American Journal of Kidney Diseases
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AJKD, official journal of @kidney.org, is the leading source of information devoted to clinical nephrology research and practice. AJKD.org | AJKDblog.org | Organizer of #NephMadness @nephmadness.bsky.social
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The October 2025 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4mGAkpD
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Editorial by Isabelle Ethier and Caroline Stigant:

Operationalizing Environmental Sustainability in Kidney Care at System and Provider Levels: Knowledge Is the First Step

bit.ly/3VTtHFn (FREE)
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Association of Sex With All-Cause and Cause-Specific Peritoneal Dialysis Discontinuation

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#VisualAbstract
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Carbon Emissions From Different Dialysis Modalities: A Life Cycle Assessment

bit.ly/Barraclough2... #OpenAccess

#VisualAbstract
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Immunofluorescence and Electron Microscopy in Genetically Engineered Pig-to-Human Kidney Xenotransplantation: A Case Report

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Case 1 xenografts. (A) Left preimplantation biopsy shows glomerulus with mild increase in mesangial matrix and segmental increase in mesangial cellularity (periodic acid-Schiff hematoxylin, ×20). (B) Right postimplantation biopsy, postoperative day (POD) 2, shows diffuse tubular epithelial cell necrosis with loss of nuclei and frequent granular casts. The glomerulus shows rare lumina occluded by fibrin thrombi (arrows); the rest of the capillaries are congested (periodic acid-Schiff hematoxylin, ×20). (C) Left preimplantation biopsy; immunofluorescence shows global granular staining for immunoglobulin M (IgM) limited to the mesangium (fluorescein isothiocyanate anti-human IgM). (D) Right preimplantation biopsy shows electron-dense immune complex deposits within the expanded mesangium (uranyl acetate and lead citrate, ×4,000).
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Core Curriculum by Kristen Tillquist et al.

The Nephrologist’s Perspective in Evaluation and Management of Localized Renal Masses

bit.ly/4o6z0NG #OpenAccess
Renal Cell Carcinoma Subtypes Based on Histology. (A) Clear cell renal cell carcinoma. (B) Papillary renal cell carcinoma. (C) Chromophobe renal cell carcinoma. (D) Oncocytoma. (E) Medullary renal cell carcinoma.
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In the Literature by Momen Abbasi and Anand Srivastava:

Advancing Noninvasive Imaging to Quantify Kidney Fibrosis: Hidden in Plain Sight

bit.ly/46TMIwB (FREE)
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The October 2025 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4mGAkpD
ajkd.bsky.social
Prevalence of the M1 Modifier p.N264K in APOL1 Among Individuals With Kidney Disease Undergoing Commercial Genetic Testing in the United States

bit.ly/48PB2xk (FREE)
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Perspective by Sireesha Koppula, Krishna Patel, and Mark Unruh:

The Delivery of Kidney Care in Rural or Sparsely Populated Settings

bit.ly/KoppulaPERS25
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Editorial by Brittany Watson and Clarissa Diamantidis:

Missed Opportunities: Rethinking Primary Care Engagement in Dialysis-Dependent Populations

bit.ly/4nAGl7U (FREE)
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From the Special Collection featuring the top cited OIs published in 2022-2023 that contributed to AJKD’s 2024 Impact Factor of 8.2:

Variation in Peritoneal Dialysis–Related Peritonitis Outcomes in the Peritoneal Dialysis Outcomes and Practice Patterns Study

bit.ly/3fYxa04 (free until 10/8)
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#RenalPath: AJKD Atlas of Renal Pathology: Diffuse Mesangial Sclerosis

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 Diffuse mesangial sclerosis with glomerular sclerosis and interstitial fibrosis (periodic acid–Schiff stain).
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Incidence and Adverse Outcomes of Acute Kidney Disease: A Systematic Review and Meta-Analysis

bit.ly/Yang25OI #OpenAccess

#CKD #AKI
Study flow chart. Abbreviation: AKD, acute kidney disease.
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The October 2025 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4mGAkpD
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#Quiz from October 2025:

A 16-year-old patient presented to an emergency department with a 3-week history of progressive headaches, nausea, vomiting, and bilateral blurry vision. Over the past 3 days, he developed chest pain and shortness of breath.

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(A) Diffuse medium and small renal arterial stenoses (yellow arrows) and microaneurysms (red arrows). (B) Intact large abdominal vessel angiogram and a small splenic artery aneurysm (red arrow in inset). (C). Distended arteriole occluded by a thrombus (arrowhead), consistent with thrombotic microangiopathy (PAS stain, ×200).
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Core Curriculum by Craig E. Gordon et al:

Autosomal Dominant Polycystic Kidney Disease: Core Curriculum 2025
bit.ly/465twwK (FREE)
 The Mayo Imaging Classification of ADPKD description (left panel) and imaging examples (right panel) with examples (right panel) of (a, b) subclass 1A and 1E, (c-f) subclass 2A, and (g, h) subclass 2B. Abbreviations: ADPKD, autosomal dominant polycystic kidney disease; TKV, total kidney volume. Reproduced with permission of the copyright holder (Kidney Disease: Improving Global Outcomes) from Kidney Disease: Improving Global Outcomes (KDIGO) ADPKD Work Group. KDIGO 2025 Clinical Practice Guideline for the Evaluation, Management, and Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD). Kidney Int. 2025;107(suppl 2S):S1-S239. doi:10.1016/j.kint.2024.07.009
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Effectiveness of Bivalent mRNA COVID-19 Vaccine Among Adults With Kidney Failure Receiving Dialysis: A Cohort Study From the Centers for Medicare and Medicaid Services by Amanda Payne et al.

bit.ly/46Ca2jC
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In this review by Rochella Ostrowski, guidelines from consensus groups are discussed with a focus on management of gout in patients with chronic kidney disease and appropriate dose adjustments beyond traditional kidney-dosed limits:

bit.ly/42iMWMk (FREE)
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Hyperkalemia-Related Discontinuation of Renin-Angiotensin-Aldosterone System Inhibitors and Clinical Outcomes in CKD: A Population-Based Cohort Study

#VisualAbstract

bit.ly/3VHJMxV
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Transition of Care of Kidney Recipients from Transplant Centers to Referring Nephrologists: Report From the American Society of Transplantation Controversies Conference

bit.ly/4o3SMJW
ajkd.bsky.social
The October 2025 issue is available now! Check out the plain-language summaries on what inspired each study, the basic approach taken, what was learned, and why it matters:

bit.ly/4mGAkpD
ajkd.bsky.social
Mini-Review by Ian Da Silva Lugo and Jaime Uribarri:

Tenapanor: An Update on Evidence of Effectiveness and Guidance on Practical Use

bit.ly/Lugo25MR (FREE)

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Nephrologist Perspectives on Using Telemedicine During In-Center Hemodialysis: A Qualitative Study

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Benefits and Barriers to Hybrid Use of Telemedicine & In-Person Visits for In-Center Hemodialysis
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Primary Care Use and Clinical Outcomes Among Patients Initiating Hemodialysis

bit.ly/46baANd #OpenAccess

#VisualAbstract
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Editorial by Christopher H. Grant, Simon Sawhney, and Samira Bell:

Reframing Acute Kidney Disease: Two Coins or Two Sides?

bit.ly/Grant25ED (FREE)