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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 15h

As always, thanks to @agarvil.bsky.social (the protagonist of this serendipitous discovery), Antonio Moreno, Alex Rubio, and the original work of the group's new thesis candidate, Elisa Luque.

Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 15h

But it was contamination. Bit by bit, we pieced it together — and here it is, the complete genome assembly of a new A. guillouiae strain.

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 15h

This project began by pure serendipity: while analyzing a soil mite genome, Oppiella nova. We found sequences from an Acinetobacter bacteriophage. It initially led us to believe that this was a case of horizontal transfer.

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 15h

New article from our UPOBioinfo group! 🧬
We’re now exploring bacteria hidden in arthropod genome assemblies @microbiologysociety.org @cabd-upo-csic.bsky.social

www.microbiologyresearch.org/content/jour...

Discovery of a bacteriophage sequence in a mite genome assembly reveals bacterial contamination and opens new possibilities for exploring arthropod symbionts

While studying the integration site of a bacteriophage associated with the bacterium Acinetobacter baumannii, we found a genome assembly of the mite Oppiella nova that contained a homologous sequence ...

www.microbiologyresearch.org

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 9d

Gracias por el apoyo y financiación a @FundameNet @ElcaminodeElena y @galici_ame

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 10d

This suggests that sphingolipids such as ceramide could be a possible biomarker for disease progression and monitoring.

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 10d

We have found a modifier of SMN, acid sphingomyelinase, and drugs that inhibit it and increase SMN protein levels. Most importantly, we have linked sphingolipid metabolism to SMA for the first time.

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 10d

We are proud to present our multidisciplinary collaboration (bioinformatics, nematodes, cell cultures) on Spinal Muscular Atrophy (SMA). It has been fascinating to work on my disease with this great team!

Inhibition of acid sphingomyelinase increases SMN levels and connects sphingolipid metabolism to Spinal Muscular Atrophy

Spinal Muscular Atrophy (SMA) is a moderately rare disease that causes progressive motor neuron degeneration and presents the highest neonatal death r…

www.sciencedirect.com

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · 13d

New photo of UPOBioinfo Group 2025-2026 - Bacteriophages and their relationship with CRISPR-Cas and other defense systems in bacteria.

Looking forward to a year of fascinating stories about bacteria and phages!

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Reposted by Antonio J. Pérez Pulido 🧬🦠💻🦼

Microbiology Society @microbiologysociety.org · Sep 8

Join us for Annual Conference 2026!

Abstract submission and registration are open for the UK’s largest annual gathering of microbiologists.
Held in Belfast, UK, this year’s Conference also features two-day attendance tickets.

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Aug 24

Me apunto el libro, @lluismontoliu.bsky.social

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Aug 24

Un tipo llamado Fred Sanger montoliu.naukas.com/2025/08/24/u...

Un científico de los de verdad, no de los que quieren ahora. En esos tiempos, publicar era sinónimo de hacer Ciencia y sólo publicar no era hacer Ciencia.

Un tipo llamado Fred Sanger - Gen-Ética

Este verano hemos pasado unos días en Cambridge (Reino Unido), ciudad universitaria por excelencia y sede de prestigiosos e históricos centros de investigación. Estos centros convierten a Cambridge en...

montoliu.naukas.com

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Reposted by Antonio J. Pérez Pulido 🧬🦠💻🦼

Centro Andaluz de Biología del Desarrollo @cabd-upo-csic.bsky.social · Aug 20

🆘 #Flybase needs YOUR help🪰

FlyBase @flybase.bsky.social · Aug 15

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

FlyBase:Contribute to FlyBase - FlyBase Wiki

wiki.flybase.org

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Aug 18

Now reading... At last I can travel around Australia!!!

Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Aug 18

This is a great result from Antonio Moreno's thesis, with the essential help of Alex Rubio and Andrés Garzón, and the invaluable collaboration of Younes Smani.

Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Aug 18

Today, our UPOBioinfo group presents the defensome of Acinetobacter baumannii.
Do you know about its concerning Global Clone 2? Well, part of its success could be due to the replacement of restriction-modification systems by Ssp antiviral systems.

The evolutionary replacement of restriction-modification by Ssp antiviral systems is associated with the distribution of prophages in the major clonal group of Acinetobacter baumannii | mBio

Acinetobacter baumannii is a bacterium of great concern in clinical contexts due to the plasticity of its genome and its resistance to antibiotics. Its cells are infected by a multitude of bacteriophages, and the bacterium defends itself with dozens of ...

journals.asm.org

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Aug 13

What a wonderful book for summer! It has been amazing. Thanks @edyong209.bsky.social

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Reposted by Antonio J. Pérez Pulido 🧬🦠💻🦼

Microbiology Society @microbiologysociety.org · Jun 20

Registration is open for the Microbial Genomics of Eukaryotes meeting in Glasgow! This event will showcase diverse scientific achievements in eukaryotic genome research. Register now and submit your abstract by 12 August: microb.io/MicroGenomic...

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Jun 17

sorry, in here it is better than multiplied (X)...:
@microbiologysociety.org

Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Jun 17

And proud that it has been published in Microbial Genomics, the journal of @MicrobioSoc, a membership charity and not-for-profit publisher that supports inclusive research.

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Jun 17

#Irene has been an excellent student of our master's degree in Advanced Bioinformatics Analysis and this has been the result of her Master's Thesis, tutored by #AlexRubio and myself.

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · Jun 17

New paper published in our computational biology group for the study of phages, of which we are especially proud: "Bacteriophages in Pseudomonas aeruginosa evade the CRISPR-Cas I-F system by depletion of PAM sequences".

Bacteriophages in Pseudomonas aeruginosa evade the CRISPR-Cas I-F system by depletion of PAM sequences

Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins systems provide bacteria with an adaptive immune system against exogenous sequences, such as pla...

www.microbiologyresearch.org

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Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · May 15

Qué orgulloso de mis niñ@s, que se van haciendo mayores 🤍

Antonio J. Pérez Pulido 🧬🦠💻🦼 @ajperezpulido.bsky.social · May 1

Gran Video Podcast de Rubén en Fundame. Si quieres saber más sobre AME y lucha entre fagos, dejo por aquí la entrevista que me hicieron y que acaba de ser publicada.
youtu.be/hEl1PnVJl5I?...

Lo que enseñan virus y bacterias para curar enfermedades. Antonio J Pérez Pulido . AMEnízAME

YouTube video by Fundame España

youtu.be

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Reposted by Antonio J. Pérez Pulido 🧬🦠💻🦼

The Conversation ES @es.theconversation.com · Feb 28

Hoy es el Día Mundial de las #EnfermedadesRaras y recordamos que @ajperezpulido.bsky.social (@pablodeolavide.upo.es) ya nos contó que sufre la 'enfermedad más bonita del mundo':

Por qué sufro la enfermedad más bonita del mundo (y la más cara de tratar)

La atrofia muscular espinal, que sufre el autor del artículo, es una de las enfermedades genéticas con mayor mortalidad asociada. Y también la más cara de curar, lo que no le quita su “encanto especial” a nivel molecular.

theconversation.com

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