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Alan Parker @alanlparker.bsky.social · 18d

Great to have this out as a preprint - a fantastic collaborative effort led ably by the dream team of Rosie and Kasim....have a look, the structures are amazing!

bioRxivpreprint @biorxivpreprint.bsky.social · 18d

Identification of a novel structural motif and overexpression of key transcripts elucidated in Adenovirus 10 https://www.biorxiv.org/content/10.1101/2025.09.20.677498v1

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Alan Parker @alanlparker.bsky.social · 18d

Great to have this out as a preprint - a fantastic collaborative effort led ably by the dream team of Rosie and Kasim....have a look, the structures are amazing!

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 18d

Identification of a novel structural motif and overexpression of key transcripts elucidated in Adenovirus 10 https://www.biorxiv.org/content/10.1101/2025.09.20.677498v1

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Alan Parker @alanlparker.bsky.social · Sep 1

Potential @gw4biomeddtp.bsky.social 4 year PhD project for Oct 2026 start adopting machine learning to develop precision virotherapies - co-supervisors Yukun Lai, @mariekedoesscience.bsky.social, Kerry Wadey & Julian Fischer. Come, make some smart viruses with us!

gw4biomed.ac.uk/developing-p...

Developing precision guided, viral based therapies using machine learning approaches - GW4 BioMed MRC DTP

Project Code MRCIIAR26Ca Parker Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary The Viral ImmunoTherapies and Advanced The...

gw4biomed.ac.uk

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Reposted by Alan Parker

Advanced Therapies Wales @atwales.bsky.social · Sep 1

Make sure you don't miss our next #Advancedtherapies MDRG on Friday.

Hear from Dr Michael Chapman -'CAR-T therapy in haematological malignancy' and Professor Andrew Sewell 'How T-Cells clear cancer'

Virtual option available

#Research

@alanlparker.bsky.social @lifesciencescymru.bsky.social

next meeting Friday 5th September 1-2.30pm at Cancer Genetics Building, University Hospital of Wales, Cardiff CF14 4XN

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Reposted by Alan Parker

Dr Bayliss @drbayliss.bsky.social · Jul 28

Very excited our paper describing the development of a precision Virotherapy directly delivering bispecific molecules to tumour cells is in it's final polished form!
www.cell.com/molecular-th...

An αvβ6-specific virotherapy expressing bispecific immune cell activators induces immune cell activation to mediate tumor cell death

Virotherapies can deliver anti-cancer therapeutics directly to tumors. Bayliss and colleagues develop a precision virotherapy expressing bispecific immunotherapies from tumor cells resulting in immune...

www.cell.com

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Reposted by Alan Parker

Dr Luned Badder @lunedbadder.bsky.social · Aug 8

Am Sdeddfod wych!! Diolch o galon i bawb ddaeth i'n gweld ni ym mhabell @prifysgolcdydd.bsky.social, i ddysgu mwy am ein gwaith yn Uned firoleg gymhwysol Cymru Wales Applied Virology Unit (WAVU). Braf odd cal gweld y "firysau" oddachi wedi ei greu o gwmpas y maes!

Image of paper virus templates, and materials used for building

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Alan Parker @alanlparker.bsky.social · Aug 8

Doh! 🤦🏻‍♂️. Thanks for seconding anyway 😂👍🏻

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Alan Parker @alanlparker.bsky.social · Aug 6

If you’re visiting #Eisteddfodd today, do speak to the awesome @lunedbadder.bsky.social representing @cardiffunilib.bsky.social, the VITAL lab & HCRW Wales Applied Virology Unit (WAVU), explaining how we develop “#SmartViruses” to treat #Cancer. You can even make a designer virus of your own!

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Alan Parker @alanlparker.bsky.social · Jul 8

Congratulations to @gw4biomeddtp.bsky.social @atwales.bsky.social funded PhD student Rosie Mundy, presenting her groundbreaking structural and transcriptomic analysis of Ad10 today at the International Adenovirus Meeting at @cardiffunilib.bsky.social centre for student life.

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Reposted by Alan Parker

Molecular Therapy @moltherapy.bsky.social · Jun 26

An αvβ6 specific precision virotherapy expressing bispecific immune cell activators induces immune cell activation and mediates tumour cell death.

Virotherapies can deliver anti-cancer therapeutics directly to tumours. Bayliss and colleagues develop a precision virotherapy expressing bispecific immunotherapies from tumour cells resulting in immune cell activation and tumour cell killing. Combination cancer therapy has potential to enhance regression of solid tumours in a targeted manner improving on current approaches.

dlvr.it

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Alan Parker @alanlparker.bsky.social · May 26

Big moment for the youngest, collecting his first cap for @glamcricket.bsky.social U13 yesterday. Two terrific matches against a strong Gloucestershire U13 but showed their class securing back to back T20 wins. Exciting times ahead! 👏👏🏏 💥

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Alan Parker @alanlparker.bsky.social · May 21

Thanks for inviting me to be an honorary @pharmacycu.bsky.social member for and to talk "how to train your virus" at the ever wonderful @pintofscience.uk event at Tiny Rebel, Cardiff! A great evening talking about crossing the "Valley of Death" and into the clinic with our "smart viruses".

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Alan Parker @alanlparker.bsky.social · May 5

Looking forward to my favourite #PublicEngagement event @pintofscience! I'll talk "how to train your virus" at @TinyRebelCdff on 20/05, discussing how we turned a disease causing "nasty" into a clinical stage anticancer medicine. Grab a pint, pop along! pintofscience.co.uk/event/from-b...

A photograph of Alan Parker next to text describing his talk on "How to train your virus" for Pint of Science 2025

Alan Parker @alanlparker.bsky.social · May 2

Thrilled and honoured to be announced as a Health and Care Research Wales Senior Research Leader. Looking forward to contributing towards accelerating translational research, shaping policy and mentoring the next generation of researchers in Wales.

healthandcareresearchwales.org/about/news/h...

Health and Care Research Wales announces appointments of Senior Research Leaders

healthandcareresearchwales.org

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Alan Parker @alanlparker.bsky.social · Apr 16

Reposting the job link!

krb-sjobs.brassring.com/TGnewUI/Sear...

Lecturer in Infectious Disease Epidemiology / Beha - Cardiff University - Job Details

Job Details: Lecturer in Infectious Disease Epidemiology / Infectious Disease Behavioural ScienceWAVU / Centre for Trials R

krb-sjobs.brassring.com

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Alan Parker @alanlparker.bsky.social · Apr 16

Join our new Wales Applied Virology Unit as a Lecturer in Infectious Disease Epidemiology / Behavioural Science!

See the advert here:

krb-sjobs.brassring.com/TGnewUI/Search…

And contact WAVU co-director David Gillespie for informal enquiries.

#NewPI #Lecturer #GroupLeader #Job #Opportunity

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Alan Parker @alanlparker.bsky.social · Apr 9

Well, this is exciting, and has been a long time in the making. Many thanks to the many, many exceptional authors for their expert contributions. Would make a lovely Easter gift....(who needs chocolate eggs, right...?)

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Alan Parker @alanlparker.bsky.social · Apr 9

Fantastic talk from Prof Stephanie Schorge - discussing the path to translation for taking a lentiviral therapy for epilepsy from preclinical to clinical translation! A rollercoaster of a journey many of us can relate to!

Alan Parker @alanlparker.bsky.social · Apr 9

Great to be over in London today UCL institute for child heath for what promises to be an awesome day of #AdvancedTherapies #UCL2025AdvTx . Thanks @atwales.bsky.social for funding my trip over! Looking forward to a great day!

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Reposted by Alan Parker

Advanced Therapies Wales @atwales.bsky.social · Apr 9

Fantastic to have you there representing us today @alanlparker.bsky.social

#AdvancedTherapies

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Alan Parker @alanlparker.bsky.social · Apr 1

Thanks Lindsay, glad you liked the video! Hopefully I’ll catch you at some point to say hello…

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Alan Parker @alanlparker.bsky.social · Mar 14

Huge congrats 🥂 to our latest virus tinkerer fledgling Dr Adam Naskretski MD! What a journey it’s been but my goodness you have deserved it! Many thanks to fabulous viva panel Fiona Errington-Mais, Mererid Evans and @alextonks.bsky.social for chairing! 👏🎉👍🏻🥳🦠

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Reposted by Alan Parker

thetranscendedman @atranscendedman.bsky.social · Mar 12

Scientists found that the AstraZeneca COVID-19 vaccine can infect endothelial cells but doesn’t activate them, suggesting it’s not a direct cause of VITT.

The vaccine’s hexon protein binds PF4, supporting a role in triggering the immune response.

www.biorxiv.org/content/10.1...

Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT

Background: Vaccines against SARS-CoV2 have been essential in controlling COVID-19 related mortality and have saved millions of lives. Adenoviral (Ad) based vaccines have played an integral part in th...

www.biorxiv.org

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Alan Parker @alanlparker.bsky.social · Mar 11

Preprint klaxon: Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT.

Providing evidence of direct PF4 binding to purified hexon protein, & efficient, CAR independent transduction (but not activation) of ECs by ChAdOx1

www.biorxiv.org/content/10.1...

Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT

Background: Vaccines against SARS-CoV2 have been essential in controlling COVID-19 related mortality and have saved millions of lives. Adenoviral (Ad) based vaccines have played an integral part in th...

www.biorxiv.org

Reposted by Alan Parker

bioRxivpreprint @biorxivpreprint.bsky.social · Mar 11

Investigating endothelial cell transduction and hexon:PF4 binding of ChAdOx1 in the context of VITT https://www.biorxiv.org/content/10.1101/2025.03.09.642192v1

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