ROS Signalling, not ROS Damage: A new Paradigm in Ageing youtu.be/yt1kiuOyNtY?... via
@YouTube
#Aging #ROS #Drosophila #Mitochondria

Exciting news! Our most important work is out as preprint!

We suggest sildenafil as a treatment for mitochondrial disease Leigh syndrome, from stem and organoid model to mice and off-label use.

Next step is the clinical trial starting early next year!

www.medrxiv.org/content/10.1...

NAD+ Boosters: Slowing Aging or Selling Hype? youtu.be/0QxzAz9B--Y?... via
@YouTube
#aging #healthyaging #NAD+ #NADH #muscle #supplements #hype

What's Aging? A Survey Among Professionals youtu.be/iX_QUwrHkfY?... via @YouTube #aging #surve #disagreement

NAD+ Boosters: Slowing Aging or Selling Hype? youtu.be/0QxzAz9B--Y?... via
@YouTube
#aging #healthyaging #NAD+ #NADH #muscle #supplements #hype

Age Deceleration and Reversal in C elegans youtu.be/QSmpKDEjYNA?... #aging #worms #celegans #dauer

How does a Fly Die? And why should we care? #Drosophila #Aging #Biology

youtu.be/-akcyD68-eA?...

A concise and excellent summary of our recent
@emboreports.org manuscript, now published in
@natsmb.nature.com.
www.nature.com/articles/s41...

New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.

A podcast discussing our paper on the role of CI on aging and mitochondrial disease:

www.youtube.com/watch?v=Usu7...

Thanks to the paper's first author,
@rhodophila
, all our collaborators, and Wellcome and BBSRC, among others, for funding this study.

Finally, it's too early to know if this happens in humans. If it does, early treatment of mitochondrial disease is crucial. If not, we must learn how adult flies cope with minimal CI and apply that knowledge to #humans.

#Omics analysis reveals differences between short- and long-lived individuals. These can be explored to identify which features of CI depletion are pathogenic (found only in short-lived flies) and which are not (found in long-lived flies).

Our results identify development as the critical stage where CI must function optimally, while age-related CI reduction in activity may act as an anti-ageing adaptation.

If we massively reduce CI levels only in adult flies, they do not live shorter but instead live longer than controls. Notably, this depletion exceeds the levels observed in aged flies and is comparable to the reduction seen in individuals suffering from #mitochondrialdisease.

During development, a small disruption of mitochondrial #ComplexI (CI) in #Drosophila enormously shortens adult lifespan. This disruption falls within the natural variability in mitochondrial respiration observed among wild-type strains.

New paper from my laboratory in EMBO Reports doi.org/10.1038/s443.... Our study challenges what we know about #mitochondria & #aging.