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Alessandro Donada @alessandrodonada.bsky.social · Aug 1

Reposted by Alessandro Donada

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jul 30

The #ISEH2025 🏯 program is here and features world-renowned scientists showcasing the latest in experimental hematology. Don't miss these sessions, including the ISEH/JSH symposium on stress hematopoiesis with Drs. Toshio Suda and Hitoshi Takizawa ➡️ www.iseh.org/2025Scientif...

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Alessandro Donada @alessandrodonada.bsky.social · Jul 31

So interesting!

Blood Journals' Portfolio @bloodjournals.hematology.org · Jul 30

LS, an emergent form of acute leukemia relapse after antigen-targeted therapy, primarily in B-ALL, has dismal outcomes. buff.ly/59xI6qv #hemesky

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Alessandro Donada @alessandrodonada.bsky.social · Jul 25

A gentleman and a scholar indeed! What a pleasant chat with @abattacks.bsky.social, make sure to check out our interview! Also, a submitted post from @lvchosen1.bsky.social and at least 25 preprints to review! #hemesky

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jul 24

The July #PreprintWatch features 25 fresh preprints that span hematopoietic development, leukemogenesis, and the latest in tech development. Plus, a video chat with @abattacks.bsky.social - one of our featured community submitters! Explore on www.simplyblood.org

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Alessandro Donada @alessandrodonada.bsky.social · Jul 21

Let's do this!

perielab.bsky.social @perielab.bsky.social · Jul 17

Happy to have received a POC ERC to scale up the microscopy of motile cells, like our favorite hematopoietic cells, using microchip and AI based image analysis! project with the very best: @alessandrodonada.bsky.social, Morgane Burg, Hervé Isambert and Tizziana Tocci. Thank you ERC!

Over €20 million to turn frontier science into practical solutions

The European Research Council (ERC) has today announced the first group of researchers to be awarded ERC Proof of Concept Grants in 2025. In this initial round of the 2025 competition, 150 projects wi...

erc.europa.eu

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Alessandro Donada @alessandrodonada.bsky.social · Jul 2

Best way to keep up with the newest research! #HemeSky

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jul 1

The #PreprintWatch is here! Read the highlights of the latest and most interesting preprints on our blog www.simplyblood.org and submit your own to be featured.

simply blood

Deconstructing blood cell research, building the hematology community

www.simplyblood.org

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

This project was led with @perielab.bsky.social, with the help of amazing collaborators — shoutout to Gurvan, CSCO, Tiziana, and the clinicians.

Want to know more? Send me a message, or comment here!

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

🔮 Where are we headed next?

Can we restore epigenetic structure in AML more robustly?

How stable is clonal memory over time, stress, or environment?

Let’s find out.

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

🧨 In AML, the memory breaks down.
→ Cell families get chaotic
→ Division becomes erratic
→ Concordance is lost
But: tweaking the epigenetic landscape brings some order back.
🙏 Huge thanks to patients & clinicians who made this part possible.

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

🧬 What about gene expression?

No one-size-fits-all “family module,” but expression fingerprints are shared within families. And I want to thank the @CSCO platform at Curie for the data & Tiziana Tocci for the beautiful network analysis!

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

📐 Could this all be random?
We built a mathematical model (thanks to Gurvan Hermange) to test it.
Still:
✅ Homogeneity in fate
✅ Concordance in division
...emerged as essential features.

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

🧬 It’s not just division.
Cell families also:
→ Look alike
→ Choose similar fates
The big differences are between families, not within.
🧭 Lineage tracing was key.

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

👪 Cells from the same ancestor — “families” — often:
✔️ Divide the same number of times
✔️ At the same time ⏱️
And this holds across donors, media & time.

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

🔬 We took a multi-omic, single-cell approach:

Live-cell imaging

Single-cell RNA-seq (thanks CSCO platform!)

Custom assay for lineage + division + differentiation --> introducing MultiGen (DOI: 10.3791/64918)

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

Why HSPCs? 🩸
These stem cells build the entire blood system.
If they remember division patterns, it affects how we understand both healthy haematopoiesis and disease.

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

Cells divide, differentiate, and move on… right?
🧠 But we asked: do blood stem cells remember their past divisions?
Spoiler: they do — and it’s surprisingly organized.

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

🧬 What if your blood cells remembered how their ancestors divided?

Our new preprint (www.biorxiv.org/content/10.1...) explores clonal memory in human blood stem cells — and how it breaks down in leukaemia.

📄 "Clonal memory of cell division..."

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Reposted by Alessandro Donada

Dead Union @deadunion420.bsky.social · Jun 24

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Alessandro Donada @alessandrodonada.bsky.social · Jun 25

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Alessandro Donada @alessandrodonada.bsky.social · Jun 24

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Reposted by Alessandro Donada

HemaSphere Journal @hemasphere-journal.bsky.social · Jun 24

This Article analyzes human hematopoiesis in humanized bone marrow in immune-deficient mice, showing dynamic structures supporting human hematopoietic development. Findings emphasize significance of the models for investigating human hematopoietic development & leukemogenesis👉https://bit.ly/42Czbaw

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Reposted by Alessandro Donada

Ronan Chaligné @ronanchaligne.bsky.social · Jun 23

🚨🚨 We're hiring! 🚨🚨
The Single-cell Analytics Innovation Lab (SAIL) at @mskcancercenter.bsky.social is looking for a Junior Technician to join our wet lab team!
You'll work with spatial genomics and single-cell technologies, helping us push the boundaries of cutting-edge analysis in cancer research.

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Alessandro Donada @alessandrodonada.bsky.social · Jun 10

What are you waiting for? Best society you can be involved in!

ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · Jun 9

The ISEH Call for Volunteers closes this Wednesday. Express your interest in one of ISEH's many committees by completing our volunteer interest form. 👉 www.iseh.org/ISEHCommittees

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Alessandro Donada @alessandrodonada.bsky.social · Jun 10

Such a beautiful example of how little we know and understand about biology! In my Top3 together with tardigrades and the naked mole rat!

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Alessandro Donada @alessandrodonada.bsky.social · Jun 6

Make him pay ladies. And a lot of respect for a postdoc taking this type of stance, we can only hope to be like that.

Virginia Gewin @virginiagewin.bsky.social · Jun 5

“I want any privilege I have at this point, which I’ve worked really hard to get, to use my name because I feel like it’s my duty to stand up for science," says Nicole Maphis, first in her family to go to university.

My latest @nature.com story.
www.nature.com/articles/d41...

‘We were ready for this’: meet the scientists suing the Trump administration to reinstate terminated grants

Judge sets court date to hear the US government detail how termination directives were made.

www.nature.com

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