Alexander Valvezan
@alexandervalvezan.bsky.social
Assistant Professor at Rutgers Robert Wood Johnson Medical School.
Studying cancer signaling and metabolism, with interest in cell cycle phase-specific effects
Studying cancer signaling and metabolism, with interest in cell cycle phase-specific effects
Reposted by Alexander Valvezan
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Structural basis for mTORC1 activation on the lysosomal membrane - Nature
Cryo-electron microscopy was used to study human mechanistic target of rapamycin complex 1 (mTORC1) activation on lysosomal membranes, showing progressive recruitment by RAG–Ragulator, RHEB and R...
www.nature.com
September 17, 2025 at 9:35 PM
Finally in @nature.com 🎉
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
We uncovered step-wise mTORC1 activation on membrane: RAG–Ragulator recruits, RHEB pushes closer, and direct membrane contacts by RAPTOR + mTOR trigger full kinase activity.👉 The membrane is not just a platform — it’s part of the mechanism.
www.nature.com/articles/s41...
Reposted by Alexander Valvezan
Congrats on this awesome work!
September 18, 2025 at 9:44 PM
Congrats on this awesome work!
Reposted by Alexander Valvezan
📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT!
👇👇👇
jobs.rutgers.edu/postings/260...
👇👇👇
jobs.rutgers.edu/postings/260...
Rutgers University Employment Opportunities
jobs.rutgers.edu
September 18, 2025 at 2:10 AM
📢Interested in #CancerMetabolism and #leukemia using mouse models in vivo? Come join us!! We're looking for a #postdoc to help us drive one of our multiple currently funded projects! Friends & colleagues, please RT!
👇👇👇
jobs.rutgers.edu/postings/260...
👇👇👇
jobs.rutgers.edu/postings/260...
Very cool paper.
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
www.nature.com/articles/s41...
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
www.nature.com/articles/s41...
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry - Nature
APC/C activity is transiently inhibited to generate a pulse of glycolysis that is required for mammalian cell cycle entry.
www.nature.com
August 12, 2025 at 5:32 PM
Very cool paper.
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
www.nature.com/articles/s41...
Transient APC/C inactivation by mTOR boosts glycolysis during cell cycle entry
www.nature.com/articles/s41...
Reposted by Alexander Valvezan
Just two of thousands of such stories. substack.com/home/post/p-...
I Was Just About To When My Grant Was Cut.
We ask researchers to send us their stories of what they were working on when their research grant was cut. Today, we share the stories of Tashara and Brendan.
substack.com
July 29, 2025 at 2:15 PM
Just two of thousands of such stories. substack.com/home/post/p-...
Reposted by Alexander Valvezan
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Conservation and divergence of metabolic phenotypes between patient tumours and matched xenografts - Nature Metabolism
Rao and Cai et al. perform a detailed metabolic comparison between primary tumours from patients and their matching xenografts, which identify conserved as well as divergent metabolic patterns.
www.nature.com
July 29, 2025 at 2:56 PM
1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice.
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Reposted by Alexander Valvezan
Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!
July 9, 2025 at 12:38 AM
Inspired predominantly by insightful cryo-EM structures from Yanhui Xu’s lab and @drellisdon.bsky.social on the TSC protein complex, which we have been focused on the regulation of upstream of mTORC1 for 23 years and counting. Enjoy!
Reposted by Alexander Valvezan
Congrats to Yann Cormerais and the entire lab for this publication on a new mouse model that disconnects the primary signal from PI3K to mTORC1, involving Akt-mediated phosphorylation of TSC2, which I discovered as a postdoc in Lew Cantley's lab 23 years ago. authors.elsevier.com/a/1lDFh5Sx5g...
authors.elsevier.com
June 5, 2025 at 3:33 PM
Congrats to Yann Cormerais and the entire lab for this publication on a new mouse model that disconnects the primary signal from PI3K to mTORC1, involving Akt-mediated phosphorylation of TSC2, which I discovered as a postdoc in Lew Cantley's lab 23 years ago. authors.elsevier.com/a/1lDFh5Sx5g...
Reposted by Alexander Valvezan
Happy to share the copy-edited version of our story uncovering an ACLY-MYC feedforward loop in T-ALL! @bloodneoplasia.bsky.social @rutgerscancer.bsky.social @dasilva-diz.bsky.social
doi.org/10.1016/j.bn...
doi.org/10.1016/j.bn...
March 26, 2025 at 4:50 PM
Happy to share the copy-edited version of our story uncovering an ACLY-MYC feedforward loop in T-ALL! @bloodneoplasia.bsky.social @rutgerscancer.bsky.social @dasilva-diz.bsky.social
doi.org/10.1016/j.bn...
doi.org/10.1016/j.bn...
Hello BlueSky, finally joined and looking to reconnect with everyone here!
June 4, 2025 at 3:42 PM
Hello BlueSky, finally joined and looking to reconnect with everyone here!