amazeld.bsky.social
Didier Mazel
@amazeld.bsky.social
870 followers 240 following 30 posts
Bacterial geneticist, Prof @ Institut Pasteur.
Posts Media Videos Starter Packs
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · 6d
A fresh view on phage specificity, which challenges the traditional view of a narrow host spectrum of phages by unveiling that multihost associations are common across ecosystems kudos at @mmarbout.bsky.social &
@rkoszul.bsky.social www.nature.com/articles/s41...
Phages with a broad host range are common across ecosystems - Nature Microbiology
Proximity-ligation-based sequencing from 111 samples and 5 environments reveals that a substantial proportion of phages infect multiple species.
www.nature.com
9 22
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · 19d
I am so proud to be part of this work, that we initiated Fernando de la Cruz and I, when he was on sabbatical in my lab in 2009... it took so much time for this achievement, 1000 thanks to Raúl Fernández-López! this brought me back to my PhD on cyanobacteria genetics. www.pnas.org/doi/10.1073/...
Mutations in the circadian cycle drive adaptive plasticity in cyanobacteria | PNAS
Circadian clocks allow organisms to anticipate daily fluctuations in light and temperature, but how this anticipatory role promotes adaptation to d...
www.pnas.org
2 7 31
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · 19d
Striking and frightening 😒 "They found multiple instances of insecticide-resistance variants in this malaria vector, although most of these weren’t shared with museum specimens collected as recently as 1967, suggesting rapid emergence"
www.science.org/doi/10.1126/...
Genomic diversity of the African malaria vector Anopheles funestus
Anopheles funestus s.s. is a major human malaria vector across Africa. To study its evolution, especially under vector control pressure, we sequenced 656 modern specimens (collected 2014 to 2018) and ...
www.science.org
1 8 14
Reposted by Didier Mazel
val-meve.bsky.social
Marie-Eve VAL @val-meve.bsky.social · Aug 20
Congratulations to PhD students Jasmin Ostermayer and Noa Guzzi (co–first authors 🎉), together with Jakub Czarnecki and Alfonso Soler-Bistué, for compressing the diverse, lineage-wide literature on large extrachromosomal replicons into <5000 words and 80 references 😅
1 2 10
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Aug 20
For those who love bacterial replicons, The ultimate review, from our lab, signed by the master of their evolution.
‪@val-meve.bsky.social‬ www.sciencedirect.com/science/arti...
Taming wild replicons: evolution and domestication of large extrachromosomal replicons
Bacterial genomes often contain extrachromosomal replicons (ERs), ranging from small, mobile plasmids to large, stably inherited elements, such as meg…
www.sciencedirect.com
1 27 42
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Aug 5
Message received…
8
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Jul 28
A 2-year postdoc position in my lab, under the supervision of P-Alex Kaminski, on Z-DNA phages and the benefit given by ZTGC DNA and the replication machinery, with attempt to create a Z based minireplicon
research.pasteur.fr/en/job/a-two...
A two year post-doctoral position at the BacterialGenome Plasticity Unit starting October 1st - Research
research.pasteur.fr
48 42
Reposted by Didier Mazel
vdlorenzo.bsky.social
Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · Jul 24
A 2 yr postdoc position at the Bacterial
Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld.bsky.social in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇
1 16 11
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Jul 23
A great step for archaea : connection between chromosome organization to genome segregation in Archaea
www.nature.com/articles/s41...

congrats to @danielabarilla.bsky.social
Coupling chromosome organization to genome segregation in Archaea - Nature Communications
Proteins SegA and SegB are important for chromosome segregation and organization in archaea of the order Sulfolobales, but mechanisms are unclear. Here, Kabli et al. uncover patterns and mechanisms th...
www.nature.com
1
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Jun 23
chng.it/jNJSnj2hjQ
Avez-vous une minute pour aider cette campagne?
Sauvons BIOASTER : Un Appel Urgent pour la Recherche en Microbiologie !
chng.it
1 1
Reposted by Didier Mazel
morgan-lamberioux.bsky.social
Morgan Lamberioux @morgan-lamberioux.bsky.social · Jun 7
Thrilled to share my first PhD paper, out of the Mazel lab! @amazeld.bsky.social
We discovered that accessory peptide deformylases (PDFs) are widespread in bacteria and may provide resistance to natural inhibitors, posing a challenge to future antibiotic strategies

doi.org/10.1101/2025...
Unraveling the prevalence and multifaceted roles of accessory peptide deformylases in bacterial adaptation and resistance
Peptide deformylases (PDFs) are enzymes that are essential for bacterial viability and attractive targets for antibiotic development. Yet, despite their conserved function, many bacteria encode multip...
doi.org
5 2 9
Reposted by Didier Mazel
jaescudero.bsky.social
Jose A Escudero @jaescudero.bsky.social · May 8
Our paper is published back2back with one from @amazeld.bsky.social and @epcrocha.bsky.social labs where @baptistedarracq.bsky.social, @eloilittner.bsky.social and co. show that Sedentary Chromosomal Integrons are biobanks of phage defense systems. www.science.org/doi/10.1126/...
Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t...
www.science.org
2 9 21
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Mar 19
www.lemonde.fr/idees/articl...
« Aux Etats-Unis, la science est attaquée, entravée, et même interdite »
TRIBUNE. Immunologistes ayant travaillé aux Etats-Unis, Yasmine Belkaid et Bana Jabri dénoncent, dans une tribune au « Monde », la censure que l’administration Trump fait peser sur les scientifiques a...
www.lemonde.fr
1 3
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Feb 19
very interesting! congrats Ankur! www.biorxiv.org/content/10.1...
The molecular basis for DNA-binding by competence T4P is distinct in Gram-positive and Gram-negative species
Competence type IV pili (T4P) are bacterial surface appendages that facilitate DNA uptake during horizontal gene transfer by natural transformation. These dynamic structures actively extend from the c...
www.biorxiv.org
1
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Feb 7
🤣
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Feb 7
Next Tuesday Clement Gilbert and myself will discuss impact and extent of HGT in both prokaryotes and eukaryotes! It will be broadcasted on France Culture (in French)
nnaguet.bsky.social
Noémie Naguet de Saint Vulfran @nnaguet.bsky.social · Feb 7
Mardi 11 février, le @sciencecqfd.bsky.social de 16h portera sur le concept de transmission horizontale (TH) de matériel génétique. Ce sera sur @franceculture.fr ! Vous savez de quoi il s'agit ? 👇
a group of green bacteria on a green background .
ALT: a group of green bacteria on a green background .
media.tenor.com
3 23
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Feb 7
A spectacular discovery! Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus | Science www.science.org/doi/10.1126/...
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
www.science.org
4
Reposted by Didier Mazel
nicolasberrod.bsky.social
Nicolas Berrod @nicolasberrod.bsky.social · Jan 21
La directrice de l'Institut Pasteur prévient que "les maladies infectieuses ont toujours représenté un risque, mais elles sont aussi l’une des principales menaces de santé publique à l’avenir."

Longue interview, morceaux choisis ⤵️ @leparisien.fr

1/12 www.leparisien.fr/so...
« Désespérant » : face au « chaos écologique », la patronne de l’Institut Pasteur tire la sonnette d’alarme - Le Parisien
EXCLUSIF. Maladies infectieuses, vaccinations, origine des pathologies, sous-investissement dans la recherche… La directrice de l’Institut P
www.leparisien.fr
1 33 71
Reposted by Didier Mazel
val-meve.bsky.social
Marie-Eve VAL @val-meve.bsky.social · Jan 9
7/ The actors (II)
This was truly a memorable collaborative experience, involving multiple labs: Eric Le Cam (Gustave Roussy), Ole Skovgaard @oskov.bsky.social (Roskilde University), Abel Garcia-Pino (Université libre de Bruxelles), and the Mazel team @amazeld.bsky.social at Institut Pasteur !
1 1 2
Reposted by Didier Mazel
val-meve.bsky.social
Marie-Eve VAL @val-meve.bsky.social · Jan 9
8/ 🌍 Broader implications
This study not only highlights the elegant coordination of replication between Chr1 and Chr2 in Vibrio but the mechanism described here may reflect a broader strategy used by bacteria to integrate and stabilize secondary replicons derived from ancestral plasmids.
1 1
Reposted by Didier Mazel
val-meve.bsky.social
Marie-Eve VAL @val-meve.bsky.social · Jan 9
1/ 🔬 Our work, "Dynamic transitions of initiator binding coordinate the replication of the two chromosomes in Vibrio cholerae", is now published in Nature Communications.
Here's a thread on how we think Chr1 and Chr2 replication is coordinated in Vibrio. 🧵

Link : www.nature.com/articles/s41...
2 29 50
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Dec 8
We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...
Call for applications 2025 – Creation of new research groups at the Institut Pasteur | Research - Institut Pasteur
research.pasteur.fr
1 98 80
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Dec 3
👏👏👏👏 bravo Thibaut!
1 1
Reposted by Didier Mazel
graingerlab.bsky.social
Grainger Lab @graingerlab.bsky.social · Nov 28
PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or antibiotic resistance. Deadlines in January...

www.findaphd.com/phds/?Keywor...
grainger birmingham PhD Projects, Programmes & Scholarships
FindAPhD. Search Funded PhD Projects, Programmes & Scholarships in grainger birmingham. Search for PhD funding, scholarships & studentships in the UK, Europe and around the world.
www.findaphd.com
16 10
amazeld.bsky.social
Didier Mazel @amazeld.bsky.social · Nov 25
www.fun-mooc.fr/en/courses/r...
Resistance to antibacterial agents
The origin, risks, diagnosis, epidemiology of resistance to antibacterial agents in man and livestock worlwide, as well as preventive and countermeasures, in a « one health » perspective.
www.fun-mooc.fr
5 5