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American Journal of Transplantation @amjtransplant.bsky.social · 19h

Don't miss our October Literature Watch, "Erythropoietin as a macrophage-specific immunoregulatory switch with implications for oncology and transplantation," by Paolo Cravedi and James M. Gardner
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 1d

Check out October's AJT Report, "Is Organ Transplant the Next Medical Expertise Catastrophe?"
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 2d

The October issue is available here!
www.amjtransplant.org/current

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American Journal of Transplantation @amjtransplant.bsky.social · 5d

"Donor-derived cell-free DNA significantly improves rejection yield in kidney transplant biopsies" by Bromberg et al. is online and in press!
doi.org/10.1016/j.aj...

Figure 1: Study cohort and biopsy selection flow diagram.

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American Journal of Transplantation @amjtransplant.bsky.social · 6d

"A new principle to attenuate ischemia-reperfusion injury in kidney transplantation " by Biglarnia et al. is online and in press!
authors.elsevier.com/sd/article/S...

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American Journal of Transplantation @amjtransplant.bsky.social · 7d

"Applying patient-reported outcome measurements to improve transplant therapeutics " by Roslyn B. Mannon is online and in press!
authors.elsevier.com/a/1lqM6_aPCm...

Figure 1: Key Requirements for PROMs in Clinical Trials

American Journal of Transplantation @amjtransplant.bsky.social · 8d

In this month's issue: "Frailty in lung transplant recipients is associated with anemia and telomere dysfunction but independent of epigenetic age," by Kapse et al.
www.amjtransplant.org/article/S160...

American Journal of Transplantation @amjtransplant.bsky.social · 9d

Announcing AJT inSight: Our new feature built for engaging, multimedia-based transplant cases. Submissions now open!
For author guidelines, visit: www.amjtransplant.org/content/auth...

American Journal of Transplantation @amjtransplant.bsky.social · 12d

Check out a new article by Kim et al., "A two-threshold algorithm using donor-derived cell-free DNA fraction and quantity to detect acute rejection after heart transplantation."
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 13d

In this month's issue: "Multiplex bead immunoassay in ABO-A2-incompatible kidney transplantation," by Halpin et al.
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 14d

"Ischemia-Free Liver Transplantation As a Novel Approach to Improve Survival and Clinical Outcomes in the Acute-on-Chronic Liver Failure Scenario " by Tang et al. is online and in press!
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 15d

Check out a new article by Liu et al., "Tacrolimus prolongs corneal allograft survival and prevents dendritic cell infiltration in a myeloid-derived suppressor cell–dependent manner" from the September issue of AJT!
www.amjtransplant.org/article/S160...

American Journal of Transplantation @amjtransplant.bsky.social · 16d

🚨 Editor’s Choice 🚨
"Unraveling CD8+ T cell alloimmunity: Insights into the direct pathway of antigen recognition from modern experimental tools," by Freibaum et al.
www.amjtransplant.org/article/S160...

American Journal of Transplantation @amjtransplant.bsky.social · 19d

🚨 Editor’s Choice 🚨
"A closer examination of the ethical principles when considering active smokers as candidates for lung transplant," by Alyssa A. Perez and Lorriana E. Leard.
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 20d

🚨 Editor’s Choice 🚨
"Complex donor anatomy does not influence early donor or recipient outcomes after robotic donor hepatectomy at a high-volume center," by Yadav et al.
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 21d

🚨 Editor’s Choice 🚨
"The impact of the Banff v-lesion on rejection classification and outcomes: Insights from a multicenter study," by Wellekens et al.
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 22d

🚨 Editor’s Choice 🚨
"Cell therapy with human interleukin 10–producing ILC2s enhances islet function and inhibits allograft rejection," by Colpitts et al.
www.amjtransplant.org/article/S160...

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American Journal of Transplantation @amjtransplant.bsky.social · 23d

Listen in on the September AJT Highlights podcast; ajthighlights.podbean.com

American Journal of Transplantation @amjtransplant.bsky.social · 26d

Check out the AJT XenoBulletin where you will find updates on activity in Xenotransplantation. www.amjtransplant.org/news-do/xeno...

American Journal of Transplantation @amjtransplant.bsky.social · 27d

Spend some time reading September's Public Health Dispatch: From the CDC and WHO, "West Nile virus and other nationally notifiable arboviral diseases—United States, 2023" by Marcus R. Pereira: www.amjtransplant.org/article/S160...

American Journal of Transplantation @amjtransplant.bsky.social · 28d

👀 Check out our September Literature Watch, "Location, location, location—How real estate immunity and preservation of self are defined" by Drinkwater et al: www.amjtransplant.org/article/S160...

Figure: Selective control of Tconv cells by Treg cells. (A) Outline of the preclinical model used. (B) Tconv cells are restrained by locally enriched Treg cells. (C) Induction of inflammation following infection with modified Listeria sp. (D) scRNAseq analysis of splenic cells. LN, lymph node; LPS, lipopolysaccharides; PD-1, programmed cell death protein 1; poly I: C, polyinosinic: polycytidylic acid; scRNAseq, single-cell RNA sequencing; Tconv, Conventional T; TCR, T cell receptor; Treg, regulatory T; WT, wild-type. Created in Biorender.

American Journal of Transplantation @amjtransplant.bsky.social · 29d

Check out this month's AJT Report, "Managing the logistics of the new allocation policies." www.amjtransplant.org/article/S160...

American Journal of Transplantation @amjtransplant.bsky.social · Sep 8

The September issue is available here! www.amjtransplant.org/current

American Journal of Transplantation @amjtransplant.bsky.social · Aug 29

Read, share, and discuss: "Normothermic regional perfusion performed by a United States organ procurement organization for nonthoracic organ donors" by Sellers et al. #openaccess #liverutilization #kidney 10.1016/j.ajt.2025.04.005

Figure 1: Liver utilization by recovery cohort (%). DBD, donation after brain death; DP, direct procurement; NRP, normothermic regional perfusion.

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American Journal of Transplantation @amjtransplant.bsky.social · Aug 28

Check out a new article by Holle et al, "Gut microbiome alterations precede graft rejection in kidney transplantation patients" from the August issue of AJT! #kidneytransplant #graftrejection 10.1016/j.ajt.2025.02.010

Figure 2 Microbiome alteration precedes kidney transplant rejection. Patients with available fecal samples prior to kidney rejection (rejection group) for propensity score matched (1:2) to patients without kidney rejection (nonrejection group). (A) Plasma creatinine levels are depicted over time. The shaded area represents the 95% CI. Red bars indicate individual rejection events over time. (B) Analysis of minimum creatinine levels before and after sampling, along with the time taken to reach the first. (C) Principal coordinates analysis (PCoA) based on Bray-Curtis dissimilarity; the squares mark the centroids of each group. P value and F value from statistical comparison by PERMANOVA. (D) Number of detected operational taxonomic units (OTUs), Shannon diversity, and Simpson evenness for the propensity score–matched cohort. (E) Differential abundance analysis for bacterial taxa...

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