In the Kumbu region, near Mt. Everest

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Howard Morgan started as an engineer and professor in the early computing days, and ended up building three (four? five?) huge and import investment groups. Renaissance... Idealab... and listen for more on the early computing gods through to Bitcoin and AI.

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Fred Wilson's USV is kind of a 'nuff said, to borrow NYC comic book language. Hear the very early days and listen past through into the epilogue to hear Fred on music scenes and the process of discovery.

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Alan Patricof's been at it since he graduated from Columbia Business School just a couple years apart from Warren Buffett. And you might as well think of him in that same legend league, in Alan's case for Venture Capital. We start from the very early days and go right through today.

TESLA AT ~300X P/E — HISTORICAL CONTEXT WITH AMAZON, APPLE, MSFT, NVIDIA (All text preserved, no rich formatting, headings in CAPS) AMAZON (AMZN) Peak valuation moment: Peak P/E (TTM): approximately 563x Dec 2015 quarter: P/E 563.23 with price $33.79, EPS $0.06 (cite: turn14search0) Approx market cap then: about $320B (2015 year-end) (cite: turn6search16) Net income in 2015: $0.59B (cite: turn8search3, turn8search10)

That famous line is now Basketball, basketball, basketball. In this interview, Ballmer quite rehabilitates what I thought about his tenure at MSFT: the age of Azure (he owns more of MSFT than Bill Gates.)

Balaji at Network School: “we think the government should be 5% of GDP Vs the US (what would you zero out?) Federal spending is about 23–24% of U.S. GDP in recent years. Think of it as a big, lopsided pie with a fondness for retirees and missiles. The rough allocation looks like this: Elderly: Around 10% of GDP. This includes Social Security (~5% GDP) and Medicare (~5% GDP).

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Ben Lerer tells us what ideas led to the creation of a whole new type of media company in the 2000s -- Thrillist -- and the age of newsletters and bloggers in New York, and how the powerhouse seed-stage venture firm Lerer Hippeau came from it all.

Vitamin D. Stop taking it. The last 20 years were a lot of talk about Vitamin D. In the end, it's pointless to take it (though it doesn't hurt, except your pocketbook.) Scientific American roundup and deep dive article.

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Dennis Crowley tells us how he got to New York and the early internet culture in the media/Wall Street world: and how it all led to Foursquare.

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Albert Wenger tells me about his 20 years at USV, and how NY went from apps-mostly to deep and infra.

I think it’s an overlooked miracle drug. Taurine’s Interaction with GABAergic Signalling Taurine is a β-amino sulfonic acid abundant in brain tissue and acts as a neuromodulator. It binds and activates certain subtypes of the GABA_A receptor (ionotropic inhibitory receptor) in the human/mammalian brain, although with lower potency than GABA itself — for example, EC₅₀ ≈ 116 µM for taurine vs ~3.7 µM for GABA in one study.

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. Owen Davis tells us how advertising powered early NYC tech and the big transition post-dot-com-crash to both consumer and enterprise tech superstars from New York.

Welcome to my series on OG NY Tech -- celebrating 30 years of NY tech ecosystem, from 1995 to now. John Borthwick tells us the roots story of media and art and agencies at the heart of the early NY tech ecosystem and some of the players, and takes it through predictions for what to expect today.

Lots of noise lately: RFK, Trump, Tylenol, folate, autism. Even GSK got pulled in. The Harvard/MIT crowd I talk to says: the Tylenol link is weak. Moms take Tylenol because they’re sick, and it’s the fever itself that’s more strongly tied to ASD risk. That’s why the real research is focused on immune pathways, not acetaminophen. Folate and leucovorin? Same story—no meaningful data.

Pablos built one of the first decentralized money networks, the first experimental Blue Origin rockets, one of the first handheld computers, invented 1000s of new patents with Nathan Myhrvold, and most recently launched a deeptech venture firm called Deep Future. And now, on July 12, expect his book: "Deep Future". -- Pablos Holman and Amol on Deep Future Amol Sarva:

Remember when you were using six AIs each day? That has changed for me. I’m now 98% ChatGPT when I open an AI directly. DeepSeek gathering dust.

Good job MAGA.

MP3Experiment.com - 20th edition

There are about 10,000x more pictures of you, minutes of video, words you have written, recording minutes of your speaking than your grandparents. More than enough to clone you.

Inspired by this excellent piece by Rowan Jacobsen: Despite the standard dermatological position—“there is no safe level of sun exposure”—a growing body of research challenges this view by showing that moderate sunlight exposure is broadly beneficial to health, particularly for people with darker skin. What the evidence shows: Sunlight triggers production of vitamin D, nitric oxide, and immunoregulatory lipids—each associated with lower risks of autoimmune disease, depression, metabolic dysfunction, cardiovascular disease, and some cancers.

Because talking is the fastest way to express ideas for a person, but watching video is the fastest way to consume ideas. Here’s a concise table benchmarking human information intake and output across different modalities, roughly quantifying bandwidth in terms of bits per second (bps) or words/ideas per minute (wpm/ipm) where applicable. These are estimates grounded in cognitive psychology and neuroscience research.

Gatorade was invented in 1965 at the University of Florida by a team of researchers led by Dr. Robert Cade to help the university’s football team, the Florida Gators. At that time: The University of Florida was still segregated. The school admitted its first Black undergraduate student in 1962, but Black athletes did not begin playing varsity football there until 1969.