Establishing the composition of RNAs and proteins that defines the identities and functions of cells relies not only on the regulated biosynthesis of these molecules, but also equally importantly, on…

The biological purpose of Integrator and RNA polymerase II (RNAPII) promoter-proximal pausing remains uncertain. Here, we show that loss of INTS6 in h…

Control of the pool of available RNA polymerase II shapes how cells respond to UV stress and the efficacy of the resulting damage response.

Cacioppo, Gillis, Shlamovitz, Zeller, et al. show that CRL3ARMC5 ubiquitylates RNA Pol II at early stages of transcription as part of a major homeostatic RNA Pol II turnover mechanism. CRL3ARMC5 and the Integrator phosphatase act as complementary pathways, monitoring the quantity and quality of RNA Pol II complexes before they are licensed into elongation.