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Reposted by Angelo Frei

Stephan Hacker @stephanhacker2.bsky.social · 2d

Why is #antibiotic resistance of #bacteria such a huge threat to human #health?
Could #metal complexes help to address this challenge?

If you are interested in these questions, check out this #SciComm video by @angelofrei.bsky.social.

www.youtube.com/watch?v=MgJq...

#AMR #ChemBio #ChemSky

Antibiotic Resistance: Could Metals Be the Answer?

YouTube video by Universität Bern

www.youtube.com

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Reposted by Angelo Frei

Esther Johnston @estherjohnston.bsky.social · 2d

This cover gets one of my personal shout-outs for originality and creativity! My favourite cover image of the year so far in Chemical Science. Just the right mix of artistic, clear link to the science, and eye-catching.

Congrats to the authors! Read their paper here: doi.org/10.1039/D5SC...

Chemical Science @chemicalscience.rsc.org · 6d

Issue 37 is here! #ChemSciCovers

Our front cover this week features Michelle T. Ma, Rachel E. Nuttall et al 🤩

'Maleic anhydride derived diphosphines: adaptable chelators for receptor-targeted 99mTc, 64Cu and 188Re radiotracers'

🔗 doi.org/10.1039/D5SC...

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Angelo Frei @angelofrei.bsky.social · 3d

After 2 years of work, our flashMOOC about metal-based antibiotics is now out! The goal was to make an accessible video about the urgent problem that is antimicrobial resistance and how metal complexes could be part of the solution. Very happy with how it turned out!
www.youtube.com/watch?v=MgJq...

Antibiotic Resistance: Could Metals Be the Answer?

YouTube video by Universität Bern

www.youtube.com

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Reposted by Angelo Frei

Jan H. Jensen @janhjensen.bsky.social · 4d

My talk at the #RDKit UGM in Prague youtu.be/TduH7v-biyY?... #compchem

Jan Jensen: Can you find hits by screening only 100 molecules?

YouTube video by RDKit

youtu.be

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Chemical Science @chemicalscience.rsc.org · 6d

Issue 37 is here! #ChemSciCovers

Our front cover this week features Michelle T. Ma, Rachel E. Nuttall et al 🤩

'Maleic anhydride derived diphosphines: adaptable chelators for receptor-targeted 99mTc, 64Cu and 188Re radiotracers'

🔗 doi.org/10.1039/D5SC...

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Reposted by Angelo Frei

Sandy Kilpatrick @sandykilla.bsky.social · 8d

I don’t want to be on a picket line today. I’d rather be teaching my students or in the lab with @kilpatrickgroup.bsky.social - not standing in the rain outside my own workplace.

But the threat of compulsory redundancies and cuts to @leicesterchem.bsky.social 🇬🇧🥈leaves us no real choice.

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Reposted by Angelo Frei

Jeannine Hess @jeanninehess.bsky.social · 16d

🧪 Excited to share our new work on reactive metallo-scaffolds (r-mS)! We combine metal complexes with chemoproteomics to discover new liganding sites across the proteome! Shout out to a great collaboration with GSK! Fantastic team effort 🫶🏻 chemrxiv.org/engage/chemr...

Proteome-Wide Target Identification Using Reactive Metallo-Scaffolds (r-mS): A Platform for Metallodrug Discovery

Metal complexes offer unique opportunities as scaffolds in chemical biology and drug discovery, with tuneable geometry, modular coordination environments, and structural features not readily accessibl...

chemrxiv.org

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Reposted by Angelo Frei

Dr Nathan Kilah @chemistrynathan.bsky.social · 14d

Today we're dissolving gold in aqua regia! Gold is expensive, but in the scheme of things for a synthesis lab the price (~$183/g) is not that different to other speciality chemicals. ##ChemSky #OzChem

Gold pellets in a beaker also containing aqua regia.

Gold dissolving into aqua regia. The solution is orange and bubbles are visible at the top.

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Reposted by Angelo Frei

Jamie Blaza @jnb-lab.bsky.social · 23d

@elisafadda.bsky.social’s post is spot on about LinkedIn vs Bluesky. I like the thoughtful and critical nature of Bluesky but if you want little dopamine hits, LinkedIn will do that for you (as will many other social media sites)

Elisa Fadda @elisafadda.bsky.social · 23d

That's quite true ⬇️ now, but I am hoping the science community here will manage to reverse the order 🤓

I find LinkedIn borderline intolerable, as a continuous list of self congratulatory posts 99% of starting with "I am delighted to announce" or add your synonym for delighted.. 🙄 1/n

Roland Dunbrack 🏳️‍🌈 @rolanddunbrack.bsky.social · 23d

So for posting science now: LinkedIn >> Bluesky >>>> X.

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Reposted by Angelo Frei

Max-Planck-Gesellschaft @maxplanck.de · 24d

Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...

Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.

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Angelo Frei @angelofrei.bsky.social · Sep 7

It's been a wild last 150 Chapters or so 😅

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Ben Williamson @benpatrickwill.bsky.social · Sep 6

Academic authors, here's a peek into the black box of journal publishing from an journal editor if you can bear it:

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Angelo Frei @angelofrei.bsky.social · Sep 6

HI, ZEV!

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Angelo Frei @angelofrei.bsky.social · Aug 31

The Frei Lab returns from an intense week of Bioorganometallic Chemistry at ISBOMC25 in Paris. Congratulations to David Husbands for giving an excellent talk and Athi Welsh (Prize-winner🏆) , Çağrı Özsan and Kwok Hei Chau for presenting their posters.

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Angelo Frei @angelofrei.bsky.social · Jul 25

Bringing our automated modular synthesis to 384 well plates... but first some fun! (Second Try with Video)

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Reposted by Angelo Frei

The Babak Lab @thebabaklab.bsky.social · Jun 21

👩‍🔬 We trained a deep learning model to create a new platinum complex. It works.
Our latest research, “Overcoming Cisplatin Resistance via Deep Learning–Assisted De Novo Design of Platinum Complexes,” is now live on ChemRxiv! 🔬
Link in comments 👇
#AI #Oncology #Metallodrugs

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Reposted by Angelo Frei

Vázquez López Lab @biometalusc.bsky.social · Jun 11

Big news! 🚀
Our new paper is out in JACS!
👉 pubs.acs.org/doi/10.1021/...
“Unlocking a Biological Interface of Chiral Supramolecular Helical Polymers”
#DNAjunction #SupramolecularChem #ChemSky
@acs.org @pubs.acs.org @jacs.acspublications.org

Unlocking a Biological Interface of Chiral Supramolecular Helical Polymers

Here we report a C3-symmetric metal-binding tripeptide, BTMA-1, that self-assembles in water into either a chiral supramolecular helical polymer or a discrete CoII peptide helicate, depending on metal coordination. The CoII peptide helicate exhibits high affinity and selectivity toward DNA three-way junctions (3WJ), a class of noncanonical DNA structures with emerging biological relevance. Importantly, we demonstrate that the recognition process can be triggered dynamically by adding CoII ions to a dispersion of the supramolecular polymer, which acts as an inert precursor reservoir in physiological media. In this way, our strategy shows that chiral supramolecular helical polymers can form temporarily inactive aggregates that release discrete helicates for biomolecular recognition, such as 3WJ binding, upon metal ion coordination. Overall, this mechanism reveals a previously unexplored capability of this class of materials and offers a new approach for the design of responsive supramolecular systems for nucleic acid recognition and anticancer therapy.

pubs.acs.org

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Angelo Frei @angelofrei.bsky.social · Jun 6

We believe this method offers a rapid path to discovering optimal metal complexes with ideal properties. More on this to come soon!

Kudos to PDRA David who was the relentless driving force behind this project since joining the group last year!
#CombinatorialChemistry #Metalloantibiotics

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Angelo Frei @angelofrei.bsky.social · Jun 6

We show that these libraries can easily be screened for photophysical and catalytic properties. Finally, true to our core research interest, we've identified six promising metalloantibiotics active against Gram-positive bacteria in the nanomolar range with good therapeutic indices.

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Angelo Frei @angelofrei.bsky.social · Jun 6

🚨 Second new preprint alert! 🚨
We've developed a high-throughput method using CuAAC "click" chemistry to synthesize 192 new Ligands and 672 novel metal complexes.
This approach opens a new dimension in the exploration of transition metal complex chemical space.
doi.org/10.26434/che...

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ALT: a red background with a clock and the words breaking news

media.tenor.com

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Karges Group @kargesgroup.bsky.social · Jun 4

Check out our study in @acsmedi.bsky.social about the "Induction of Cuproptosis with a Highly Cytotoxic Tripodal Cu(II) Complex". Congrats to Ricarda and @nmontesdeocas.bsky.social @ruhr-uni-bochum.de
pubs.acs.org/doi/abs/10.1...

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Angelo Frei @angelofrei.bsky.social · Jun 1

Big thanks to our collaborators in Sweden who taught us everything we know about bacterial MoA studies in what has been a very productive collaboration. Many thanks also to the team in India for the advanced biological work done. Last but not least thanks to the @snsf.ch for support.

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Angelo Frei @angelofrei.bsky.social · Jun 1

After 2.5 years and experiments across 4 countries our comprehensive study on platinum cyclooctadiene based metalloantibiotics is now out as a preprint. It has it all: Structure-Activity exploration with some tricky chemistry, In-depth MoA studies and in vivo trials on topical infections.

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · May 31

A Platinum Butterfly Effect: Small Changes Turn an Anticancer Drug into a Non-toxic Metalloantibiotic with In Vivo Efficacy https://www.biorxiv.org/content/10.1101/2025.05.30.657029v1

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Angelo Frei @angelofrei.bsky.social · May 29

As long as AI keeps coming up with structures such as those in that image, we won't have to worry about our jobs just yet... yikes.

Reposted by Angelo Frei

David K Smith @professor-dave.bsky.social · May 28

This is perhaps the most applied research we have done, demonstrating that relatively simple glycol/water mixtures can be transformed into high-performance anti-icing systems using simple molecular gelators. This is a cost-effective approach that may lower glycol usage.
pubs.acs.org/doi/10.1021/...

Supramolecular Gels with Potential Applications as Anti-Icing Agents

Supramolecular gels based on 1,3:2,4-dibenzylidenesorbitol (DBS) with modifications in the para positions of the aromatic rings form effective thickeners for mixtures of monopropylene glycol (MPG) and...

pubs.acs.org

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