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Anoushka Dua MD @anoushkaduamd.bsky.social · Jun 27

Hold PPI for 2 weeks before H. pylori stool antigen testing? The data suggest you may not need to!
What is your practice?🤔
bit.ly/4nkpwid

S2307 Impact of Proton Pump Inhibitor Use on Stool H.... : Official journal of the American College of Gastroenterology | ACG

An abstract is unavailable.

bit.ly

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Anoushka Dua MD @anoushkaduamd.bsky.social · May 5

THE GREAT DEBATE: Blood-Based Testing:
🔹⬇️ in CRC incidence/mortality NOT as dramatic as for FIT & colonoscopy
🔹High sensitivity for any stage CRC, though notably lower for stage 1 CRC and low for advanced precancerous lesions
🔹Would take a VERY ⬆️ participation to be = FIT

Anoushka Dua MD @anoushkaduamd.bsky.social · Apr 23

I’ll be watching!!

CGA-IGC @cgaigc.com · Apr 23

Happening TODAY AT noon ET / 9 am PT
➡️Add to your calendar & get the link to join
👉https://evt.to/eugmesssw

Open to all members of the #HereditaryGICancer care team - gastroenterologists, genetic counselors, oncologists, colorectal surgeons, APPs.

Cases 👇

Reposted by Anoushka Dua MD

CGA-IGC @cgaigc.com · Apr 23

Happening TODAY AT noon ET / 9 am PT
➡️Add to your calendar & get the link to join
👉https://evt.to/eugmesssw

Open to all members of the #HereditaryGICancer care team - gastroenterologists, genetic counselors, oncologists, colorectal surgeons, APPs.

Cases 👇

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Anoushka Dua MD @anoushkaduamd.bsky.social · Apr 23

It is our responsibility as GI doctors to directly inform patients who are found to have advanced adenomas:
✅Future surveillance should occur at no > 5y intervals
✅Children? If so, should be screened starting at age 40!
I always ☎️ patients to tell them verbally!🗣️
#GISky #Gastrosky

Anoushka Dua MD @anoushkaduamd.bsky.social · Apr 5

Day 1 of the Scrubs & Heels Annual Summit, catching up with friends and mentors!
It’s going to be a great weekend ❤️
#GISky
#GastroSky
#WomeninMedicine

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Anoushka Dua MD @anoushkaduamd.bsky.social · Apr 4

YES!!!! Let’s encourage everyone else too!

Anoushka Dua MD @anoushkaduamd.bsky.social · Apr 2

Role of FIT testing in Lynch syndrome?
🔹~70% of colonoscopies in Lynch do not reveal neoplasia
🔹Threshold of 4.1µg Hgb/g feces maximizes detection of CRC, adv adenomas (89% sensitivity, 99%NPV, 94% specificity)
🔹Consider FIT in Lynch pts at low risk for CRC to extend colo interval?
👇🏽
bit.ly/3EeQZjH

Fecal Immunochemical Test to Detect Colorectal Neoplasia in ... : Official journal of the American College of Gastroenterology | ACG

viduals with Lynch syndrome performed a quantitative FIT before high-quality surveillance colonoscopy. Diagnostic performance of FIT at various thresholds ≤20 μg Hb/g feces was assessed for relevant n...

bit.ly

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 27

#Gastrosky

Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 26

So grateful for the support of our leadership in facilitating my vision for our first annual Dress in Blue Day at UCI Health!
🔹Average risk screening begins at age 45
🔹Both structural and stool-based screening tests available
🔹The best test is the one that gets done!
#ColorectalCancerAwarenessMonth

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 25

Thank you for sharing this! Absolutely agree that we need to do better in not remaining siloed in our specialties. Multiple cancers over multiple generations = red flag!

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Reposted by Anoushka Dua MD

CGA-IGC @cgaigc.com · Mar 22

📣On the occasion of #LynchSyndromeAwarenessDay we release the 1st episode of a 3-part series🔎on #research 🤝‼️

➡️Episode 1⃣ focuses on the LINEAGE consortium, a cutting-edge research🤝tackling the complexities of #LynchSyndrome

🎙️👉tinyurl.com/2s37j66e
📜👉tinyurl.com/2rpwzm5j

#HereditaryGICancer

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 22

Outstanding @amcollegegastro.bsky.social VGR yesterday by Dr. Carol Burke on my favorite topic!

👇🏽Who to test for polyposis syndrome vs Lynch syndrome
👇🏽Types of multigene panels

🧬10-34% of CRC attributed to a germline pathogenic variant, depending on age group! 😮

#Gastrosky

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Reposted by Anoushka Dua MD

CGA-IGC @cgaigc.com · Mar 19

Learn the basics & stats about #Hereditary #ColorectalCancer from a #HereditaryGICancer expert!

Easy way to learn something new as we get closer to #LynchSyndromeAwarenessDay on March 22 during #ColorectalCancerAwarenessMonth

Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

1/12 Wanted to share my 5-question "Q&A with an Expert" on 🧬Hereditary Colorectal Cancer Risk🧬 with @swatipatelmd.bsky.social
Put together as part of my involvement in the @amcollegegastro.bsky.social Evidence-Based GI group for #ColorectalCancerAwarenessMonth!
🧠 Scroll to learn more 👇🏽

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

12/12
Thank you for joining us, #Gastrosky!
Please leave your comments and questions below 👇🏽

Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

11/
References📄:
1. bit.ly/3RdSnpA
2. bit.ly/3FKSRky
3. bit.ly/4bxcAQR, bit.ly/42bmcgR
4. bit.ly/4iBxnoH, bit.ly/4hEie4T

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

10/
Q5: What are some of the latest advancements in the treatment of hereditary colorectal cancer syndromes?
#Gastrosky

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

9/
VUS: genetic alteration w/ unknown disease risk
🧬 Common, found in 30-50% of patients undergoing multigene panel testing
🧬 >90% of VUS are re-classified as benign over ⏰
⚠️ Do 🚫 recommend changing medical management based on VUS alone!

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

8/
Q4: What are the implications of identifying a ”variant of uncertain significance” on genetic testing🧬?
#Gastrosky

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

7/
NCCN guidelines excellent but complex 👇🏽
bit.ly/4iQwTei
Broadly speaking, think about referring if:
🔎 Early onset cancer age < 50
🔎 Multiple cancers or >10 polyps
🔎 Multiple cancers on same side of family
Note: absence of family hx does not 🚫 a hereditary syndrome!

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

6/
Q3: In what clinical scenarios should gastroenterology providers think about referring patients for genetic testing🧬?
#Gastrosky

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

5/
📝Simple 3Q screening tool (Kastrinos et al. 2009) is feasible!
1. FDR < 50 with CRC, CA of uterus, ovary, stomach, small intestine, urinary tract, bile duct, pancreas, brain?
2. CRC or polyps at age < 50?
3. 3+ relatives w/ CRC?

✅High sensitivity
✅Supported by MSTF on CRC

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

4/
Q2: What are the key elements of a family history that should be collected to assess the risk of hereditary colorectal cancer?
#Gastrosky

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

3/
Hereditary CRC makes up:
🔹10% of all CRC
🔹16% of all CRC in age < 50
Most common: Lynch syndrome
Caused by:
🧬MMR gene mutations including MLH1, MSH2, MSH6, PMS2
or
🧬EPCAM mutation which sits upstream of MSH2)
Prevalence: 1/279 individuals in general population👥

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Anoushka Dua MD @anoushkaduamd.bsky.social · Mar 19

2/
Q1: How common is hereditary colorectal cancer?
#Gastrosky

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