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Reposted by Antoine de Chevigny

Katherine Brown @katherine-brown.bsky.social · Mar 25

Find out more about this exciting initiative from Biology Open in this editorial and the accompanying preprint www.biorxiv.org/content/10.1...

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Antoine de Chevigny @antoinedechevigny.bsky.social · Mar 26

Great work, congrats !!!!

Antoine de Chevigny @antoinedechevigny.bsky.social · Mar 26

Very nice, congrats

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Reposted by Antoine de Chevigny

Jure Majnik @juremaj.bsky.social · Mar 3

How does a neuron get its activity? 👀

Check out our latest preprint, where we tracked the activity of the same neurons throughout early postnatal development: www.biorxiv.org/content/10.1...

see 🧵 (1/?)

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Antoine de Chevigny @antoinedechevigny.bsky.social · Mar 19

📣 We’re hiring! 🚨 PhD position to study SOCIAL CODING in mouse S1 and mPFC using longitudinal INSCOPIX recordings from WT and socially amnesic mice during social tasks! Strong data analysis & computational modeling component. Co-sup with @lorifonto.bsky.social & Leo Guignard
tinyurl.com/3hndp7uj

SOCIAL CODE | SCHADOC

tinyurl.com

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Reposted by Antoine de Chevigny

Christophe 🔬 L @christlet.bsky.social · Mar 7

More white coats, less white robes! @eddpasquier.bsky.social #standupforscience #standupforscience2025

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Reposted by Antoine de Chevigny

Christophe 🔬 L @christlet.bsky.social · Jan 9

Looking for a place to start your lab, or a join an existing team as a permanent researcher? My Institute, the INP in Marseille, has multiple open positions: associate professor, lecturer, group leader. Check more here, happy to answer questions by email or DMs! euraxess.ec.europa.eu/jobs/304107

The Institute of Neurophysiopathology (INP) welcomes tenured researchers/lecturers, and junior researchers seeking a permanent position in France to lead or strengthen its research programs

The Institute of Neurophysiopathology (INP) welcomes tenured researchers/lecturers, and junior researchers seeking a permanent position in France to lead or strengthen its research programs RESEARCHER...

euraxess.ec.europa.eu

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 28

#neuroscience #neuroskyence

Reposted by Antoine de Chevigny

Cedric Boeckx @cedricboeckx.bsky.social · Feb 28

Fantastically detailed work by @antoinedechevigny.bsky.social & collaborators, giving us insights into molecular mechanisms orchestrating the connections between glutamatergic and
GABAergic neurons throughout cortical maturation (in mice). Great work on brain wiring 🧪🧬🧠
[+ nice 🧵👇]

Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

Delighted to showcase our atlas for the inference of ligand-receptor mediated interactions between neuronal subtypes during mouse cortex development. Herculean endeavor by former PhD student Rémi Mathieu (now @alleninstitute.bsky.social) and team, in collaboration with
@LudovicTelley

Thread
🧵

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Reposted by Antoine de Chevigny

Riccardo Bocchi @bocchiric.bsky.social · Feb 24

🚀 Think all white matter (WM) astrocytes are the same? Think again! 🌟 Our latest research reveals striking regional differences that challenge existing views on astrocyte diversity and function. 🧠

www.nature.com/articles/s41...

Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter - Nature Neuroscience

White matter (WM) astrocytes differ significantly from gray matter astrocytes, with WM astrocytes in the forebrain exhibiting unique proliferation capacity, which is absent in cerebellar WM, suggestin...

www.nature.com

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 28

Very nice work

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Reposted by Antoine de Chevigny

Fanny Cazettes @fannycazettes.bsky.social · Feb 17

Excited to announce multiple #PhD & #Postdoc positions opening in my lab over the next three years as part of the #ERC Starting grant DIVERSE! Reposts appreciated 😊 #neuroscience #neuroskyence

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 28

Very nice and important paper 👏

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 28

Thank you @cedricboeckx.bsky.social for the nice comment !!!!

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 28

Very nice paper 👏

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Reposted by Antoine de Chevigny

the Node @the-node.bsky.social · Feb 25

"Developmental Timing Across Species"

@embo.org Workshop organised by @trayon.bsky.social @bassemh.bsky.social @mdiazcuadros.bsky.social @vanderhaeghenp2.bsky.social

📅6-9 May 2025
📍Paris

Submit abstract and register by 1 April:
thenode.biologists.com/developmenta...

#EvoDevoTempo

Developmental timing across species | EMBO Workshop | 6-9 May - the Node

Join us at the EMBO Workshop "EvoDevoTempo – Developmental Timing Across Species: From Mechanisms to Evolutionary Insights". Topics will include

thenode.biologists.com

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Reposted by Antoine de Chevigny

Eli Merriam @elimerriam.bsky.social · Feb 27

www.nature.com/articles/s41... awesome new work out today! From the Lee lab in the intramural research program at NIMH!

Brain-wide presynaptic networks of functionally distinct cortical neurons - Nature

Behavioural-state-dependent pyramidal neurons have a distinct pattern of long-range glutamatergic inputs, with a larger proportion of thalamic versus motor cortex inputs compared with non-behavio...

www.nature.com

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

Exciting developments ahead in LR predictions with developmental spatial transcriptomics and a focus on non-neuronal cells !!!!

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

All that, and more! Big thanks to Rémi Mathieu and
@ltelley.bsky.social who made everything go !!!! And the other collaborators of course
Thanks to funding bodies: @agencerecherche.bsky.social, @EU_H2020, @FRM_officiel, @AgenceRecherche, @Inserm, @jeromelejeune.bsky.social, @frcneurodon, @Rotary

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

9/9 These findings underscore the power of large-scale transcriptional profiling to unravel fundamental molecular mechanisms driving cortical circuit assembly.

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

8/9 This atlas not only corroborated known interactions but also enabled the discovery of novel regulators, identifying 2 cadherin superfamily members as key mediators of perisomatic inhibition in deep vs superficial layer excitatory neurons by parvalbumin-expressing basket cells

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

7/9 Our LR atlas validated key interactions like CBLN4, which drives inhibitory synapse formation on GlutNs. It showed that CBLN4 exp is specific to Sst|L2/3-L5 fan-MCs, and predicted NEO1 as its primary receptor in the cortex. Proximity ligation assays confirmed this prediction

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

6/9 LRs linked to autism and epilepsy were widely used in the somatosensory cortex (examined here), while LRs linked to schizophrenia and intellectual disabilities may affect interactions beyond this area.

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

5/9 While neuron-pair specific LRs were rare, most LRs were shared by a relatively small subset of possible neuron-pairs (<100 out of 729 cell pairs). Ultimately, specificity arose from the unique combinations of these LRs per neuron-pair.

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Antoine de Chevigny @antoinedechevigny.bsky.social · Feb 27

4/9 We then built an atlas predicting LR-mediated neuron-neuron interactions during cortical dev. It integrates the exp of ~8K LRs with downstream transcriptional networks across 729 neuronal pairs, prioritizing LR interactions based on known connectivity and neuronal maturation.

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