Antonin Nourisson
@anton1nouriss.bsky.social
PhD in Biochemistry and Molecular Biology
Post-doc in Mart Krupovic's lab in Institut Pasteur, Paris.
Post-doc in Mart Krupovic's lab in Institut Pasteur, Paris.
🌍 Beyond Paramecium, our study sheds light on how DNA polymerases evolve new functions. This helps us understand both the flexibility and limits of DNA repair machineries across life.
August 20, 2025 at 2:15 PM
🌍 Beyond Paramecium, our study sheds light on how DNA polymerases evolve new functions. This helps us understand both the flexibility and limits of DNA repair machineries across life.
⚡ Key finding: PolX enzymes in Paramecium are specialized & diversified. They show striking trade-offs between accuracy and adaptation to unusual DNA substrates, reflecting evolutionary fine-tuning.
August 20, 2025 at 2:14 PM
⚡ Key finding: PolX enzymes in Paramecium are specialized & diversified. They show striking trade-offs between accuracy and adaptation to unusual DNA substrates, reflecting evolutionary fine-tuning.
🧬 We explored their fidelity and specialization:
How accurately do they replicate DNA?
Do different PolX enzymes have distinct functions?
How did they evolve to meet Paramecium’s unique genomic needs?
How accurately do they replicate DNA?
Do different PolX enzymes have distinct functions?
How did they evolve to meet Paramecium’s unique genomic needs?
August 20, 2025 at 2:14 PM
🧬 We explored their fidelity and specialization:
How accurately do they replicate DNA?
Do different PolX enzymes have distinct functions?
How did they evolve to meet Paramecium’s unique genomic needs?
How accurately do they replicate DNA?
Do different PolX enzymes have distinct functions?
How did they evolve to meet Paramecium’s unique genomic needs?
🔬 Our work focuses on Paramecium’s PolX DNA polymerases, unusual enzymes that play key roles in programmed genome rearrangements. These processes are essential for the development of the somatic genome in ciliates.
August 20, 2025 at 2:14 PM
🔬 Our work focuses on Paramecium’s PolX DNA polymerases, unusual enzymes that play key roles in programmed genome rearrangements. These processes are essential for the development of the somatic genome in ciliates.