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Andrew Octavian Sasmita

@aosasmita.bsky.social

1.5K followers 470 following 140 posts

Neuro postdoc at UCC 🇮🇪 PhD at MPI-NAT, 🇩🇪 | Alzheimer's x glia x sex differences x gut microbiome 🔬🧠 | (he/they) 🏳️‍🌈

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Andrew Octavian Sasmita @aosasmita.bsky.social · Jan 20

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.

Thread below: (1/11)

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease

The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying cerebral plaque burden depending on the parental source of the transgene. Mice inheriting the transgene paternally...

www.cell.com

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Reposted by Andrew Octavian Sasmita

Ana Dorrego Rivas @adorrego.bsky.social · 5d

Dendritic nanotubes! What’s next?

www.science.org/doi/10.1126/...

Intercellular communication in the brain through a dendritic nanotubular network

Intercellular nanotubular networks mediate material exchange, but their existence in neurons remains to be explored in detail. We identified long, thin dendritic filopodia forming direct dendrite–dend...

www.science.org

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Andrew Octavian Sasmita @aosasmita.bsky.social · 6d

Presented our work at the Glia Congress 2025 a few months ago on the topic of oligodendrocytes in Alzheimer’s disease and was awarded the stipend! Many thanks to the organizers and grateful for the wonderful discussions with old and new connections.

European Glial Meeting 2027 | Bologna @gliameeting.bsky.social · 6d

GLIA 2025 #StipendSpotlightSeries
Andrew Octavian Sasmita (aosasmita.bsky.social), UCC researcher, reveals how oligodendrocytes—not just neurons—drive amyloid-β plaque formation in Alzheimer’s. His work points to new OL-targeted strategies to slow disease progression and protect white matter.

Reposted by Andrew Octavian Sasmita

Ian Kremer @leadcoalition.bsky.social · 15d

New landscape of the diagnosis of Alzheimer's disease www.thelancet.com/journals/lan... by @thelancet.com

#Alzheimers #dementia #biomarkers #neuroscience #NeuroSkyence

New landscape of the diagnosis of Alzheimer's disease

Alzheimer's disease involves a drastic departure from the cognitive, functional, and behavioural trajectory of normal ageing, and is both a dreaded and highly prevalent cause of disability to individu...

www.thelancet.com

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Reposted by Andrew Octavian Sasmita

Christophe 🔬 L @christlet.bsky.social · 21d

Our new preprint is up! This is the main postdoc work of @wiesner-t.bsky.social focusing on exocytosis along the axon shaft and its regulation by the sub membrane actin-spectrin scaffold: www.biorxiv.org/content/10.1...
Read the thread below for a summary of our findings 🧵1/11

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Andrew Octavian Sasmita @aosasmita.bsky.social · 15d

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes

link.springer.com/article/10.1...

Alpha synuclein-mediated cytoskeletal dysfunction impairs myelination in human oligodendrocytes - Acta Neuropathologica

Oligodendroglial alpha-synuclein (aSyn) deposits are a key feature in the atypical parkinsonian disorder, multiple system atrophy (MSA) linked to profound myelin loss and neurodegeneration while preci...

link.springer.com

Andrew Octavian Sasmita @aosasmita.bsky.social · 17d

Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota

gut.bmj.com/content/earl...

Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota

Background The aetiology and pathogenesis of IBD are intricate, involving genetic and environmental factors. Notably, cigarette smoking has contrasting effects, being detrimental to Crohn’s disease (C...

gut.bmj.com

Reposted by Andrew Octavian Sasmita

Travis Faust @travisfaust.bsky.social · 26d

Thrilled to share our new paper @cp-cell.bsky.social:
“Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.”

This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling.

🔗 www.cell.com/cell/fulltex...

Faust et al., Cell 2025

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Andrew Octavian Sasmita @aosasmita.bsky.social · 20d

Important validation of our reported transgenic inheritance effect in a distinct 5xFAD line from the lab of David Holtzman!

www.cell.com/neuron/abstr...

Maternal inheritance suppresses CAA and amyloid plaques in 5xFAD (Tg7031)/APOE4 mice

In their recent study, Sasmita et al.1 reported that the parental origin of the 5xFAD (Tg6799) transgene substantially influences amyloid-β (Aβ) plaque deposition in this widely used amyloid model for...

www.cell.com

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Reposted by Andrew Octavian Sasmita

Institute for Stroke and Dementia Research (ISD) @isd-research.bsky.social · 23d

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease url: academic.oup.com/brain/articl...
#tao @nfranzme.bsky.social

Cortical tau deposition promotes atrophy in connected white matter regions in Alzheimer’s disease

In Alzheimer’s disease, tau pathology not only contributes to cortical atrophy but also leads to the degeneration of white matter tracts that connect diffe

academic.oup.com

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Andrew Octavian Sasmita @aosasmita.bsky.social · 23d

Mitochondria delay action potential propagation.

www.nature.com/articles/s42...

Mitochondria delay action potential propagation - Communications Biology

Modeling mitochondria-containing thin unmyelinated axons based on songbird premotor axon electron microscopy shows that mitochondria slow conduction velocity, delaying action potential propagation.

www.nature.com

Reposted by Andrew Octavian Sasmita

Pluchino lab - Regenerative Neuroimmunology @pluchinolab.bsky.social · 27d

Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies

www.science.org/doi/10.1126/...

Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies

Human myelinated brain organoids with integrated microglia can be used to investigate demyelination, remyelination, and remyelinating therapies.

www.science.org

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Andrew Octavian Sasmita @aosasmita.bsky.social · 28d

Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function

www.sciencedirect.com/science/arti...

Neurons sequester the cholesterol-inhibiting TFEB in oligodendrocyte cytoplasm to safeguard myelination and neural function

Myelination is essential for normal brain function, yet the mechanisms governing neuron-oligodendrocyte interactions that ensure proper myelination le…

www.sciencedirect.com

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Reposted by Andrew Octavian Sasmita

Hauke Werner @myelincentric.bsky.social · Sep 3

If you're interested in trafficking of #myelin constituents in #oligodendrocytes, and of course you are, you may want to check out our new preprint. It's very nice PhD work by @sophiesiems.bsky.social, and we're grateful to all who contributed!

www.biorxiv.org/content/10.1...

Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system

Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formatio...

www.biorxiv.org

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Andrew Octavian Sasmita @aosasmita.bsky.social · Sep 1

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice.

www.cell.com/cell-reports...

Amyloid-β-driven Alzheimer’s disease reshapes the colonic immune system in mice

Makhijani et al. investigate the colonic immune landscape in the 5XFAD model, showing a reduction in CXCR4+ antibody-secreting cells and a concomitant increase in brain CXCL12. Dietary intervention wi...

www.cell.com

Andrew Octavian Sasmita @aosasmita.bsky.social · Aug 25

Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy

alz-journals.onlinelibrary.wiley.com/doi/full/10....

Imaging myelin degradation in ex vivo prefrontal cortex tissue blocks in Alzheimer's disease and chronic traumatic encephalopathy

INTRODUCTION Alzheimer's disease (AD) and chronic traumatic encephalopathy (CTE) are tauopathies with gray matter (GM) myelin changes that are challenging to assess with standard imaging. New method...

alz-journals.onlinelibrary.wiley.com

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Reposted by Andrew Octavian Sasmita

Nature @nature.com · Aug 20

Nature research paper: Axonal injury is a targetable driver of glioblastoma progression

go.nature.com/4lFmpiN

Axonal injury is a targetable driver of glioblastoma progression - Nature

Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.

go.nature.com

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Reposted by Andrew Octavian Sasmita

Masha Prager-Khoutorsky @mashapk.bsky.social · Aug 19

Thrilled to share our new study showing microglia prune astrocyte processes in adult brain, to regulate synaptic transmission, hypothalamic neuron activity, and salt-induced hypertension in🐀. Huge team effort - congratulations to all🥂🍾🎉

Neuron @cp-neuron.bsky.social · Aug 19

Online now:

Microglia regulate neuronal activity via structural remodeling of astrocytes

Gu et al. showed that in rats fed a high-salt diet, reactive microglia accumulate around vasopressin-secreting neurons, phagocytosing astrocytic elements and pruning astrocytes. This causes glutamate spillover, increased neuronal activity, and excessive vasopressin release, contributing to salt-induced hypertension. The study reveals a novel mechanism by which microglia regulate synaptic transmission and neuronal activity through structural remodeling of astrocytes in the adult brain.

dlvr.it

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Reposted by Andrew Octavian Sasmita

medRxivpreprint @medrxivpreprint.bsky.social · Aug 15

Axonal Degeneration Across the Alzheimer's Disease Spectrum: A Longitudinal MRI and Fluid Biomarker Study https://www.medrxiv.org/content/10.1101/2025.08.13.25333630v1

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Andrew Octavian Sasmita @aosasmita.bsky.social · Aug 14

Restoring amyloid-β42 and γ-secretase function in Alzheimer’s disease

academic.oup.com/brain/advanc...

Restoring amyloid-β42 and γ-secretase function in Alzheimer’s disease

Espay et al. challenge the view that Alzheimer’s disease is caused by increased gamma-secretase activity and overproduction of Aβ42. Instead, they suggest

academic.oup.com

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Andrew Octavian Sasmita @aosasmita.bsky.social · Aug 7

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease

www.nature.com/articles/s41...

Hypoxia ameliorates neurodegeneration and movement disorder in a mouse model of Parkinson’s disease - Nature Neuroscience

Parkinson’s disease (PD) involves toxic protein buildup and energy failure in neurons. Continuously breathing low-oxygen air protected mice from PD-like neuronal loss and reversed symptoms, even after...

www.nature.com

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Reposted by Andrew Octavian Sasmita

Journal of Experimental Medicine @jem.org · Aug 5

Glial cells & lipoproteins coordinate lipid & immune signaling to regulate CNS #inflammation. @vinitiwari1.bsky.social & Mikael Simons review the relationship btwn lipid #metabolism & inflammation & how disruptions in this interplay contribute to neurological disorders rupress.org/jem/article/...

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Andrew Octavian Sasmita @aosasmita.bsky.social · Aug 5

The vascular contribution to cognitive decline in ageing and dementia

www.nature.com/articles/s41...

The vascular contribution to cognitive decline in ageing and dementia - Nature Reviews Neuroscience

Growing evidence suggests that reduced cerebral blood flow contributes to cognitive decline in ageing and dementia. Attwell and colleagues discuss the underlying mechanisms and functional consequences...

www.nature.com

Andrew Octavian Sasmita @aosasmita.bsky.social · Aug 1

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease

translationalneurodegeneration.biomedcentral.com/articles/10....

Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s disease - Translational Neurodegeneration

Background Pathological deposition of hyperphosphorylated tau in the brain closely correlates with the course of Alzheimer’s disease (AD). Tau pathology occurs in axons of affected neurons and tau rem...

translationalneurodegeneration.biomedcentral.com

Reposted by Andrew Octavian Sasmita

bioRxivpreprint @biorxivpreprint.bsky.social · Jul 26

Role of oligodendroglial ADAM10 in oligodendrocyte maturation, myelination and myelin maintenance https://www.biorxiv.org/content/10.1101/2025.07.25.666787v1

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Andrew Octavian Sasmita @aosasmita.bsky.social · Jul 25

Astrocytes (🔵) and microglia (🟡) in the hippocampus of a mouse brain for #FluorescenceFriday

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