apreston243.bsky.social
@apreston243.bsky.social
56 followers 32 following 74 posts
Editor in Chief of Microbiology, the flagship journal of the Microbiology Society
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apreston243.bsky.social @apreston243.bsky.social · 14d
New paper alert! Enterococcus faecalis FabG1 is the only β-ketoacyl-acyl carrier protein (ACP) reductase, even though it encodes two other homologues. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Two putative Enterococcus faecalis fabG genes do not encode β-ketoacyl-acyl carrier protein reductases
Enterococcus faecalis encodes three putative Escherichia coli β-ketoacyl-acyl carrier protein (ACP) reductases (FabG). The fabG1 gene is located within the operon that encodes most of the fatty acid s...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · 14d
New paper alert. Vanadate sequestration by Phycomyces blakesleeanus is accompanied by an increase in cellular lipid content. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Increase in lipid portion of Phycomyces blakesleeanus biomass induced by vanadate uptake and accumulation
Fungi are ubiquitous micro-organisms involved in various environmental processes, with a particularly important role in the transformation of metals and minerals, bioremediation and biomining. Filamen...
www.microbiologyresearch.org
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Reposted by apreston243.bsky.social
bacpop.org
John Lees @bacpop.org · 21d
The EMBL PhD programme is open until 13th October (entry ~Sep 2026):
www.embl.org/about/info/e...

We have three positions in microbial genomics at EMBL-EBI, including one in my group. Please do apply, or if you know anyone that would be interested pass on to them
EMBL International PhD Programme – Unique in the world and waiting for you!
www.embl.org
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apreston243.bsky.social @apreston243.bsky.social · 22d
New paper alert! Changes to gut microbiome profiles associate with inflammatory markers in children with cholestatic liver disease. Is dysbiosis driving the pathology? @microbiologysociety.org www.microbiologyresearch.org/content/jour...
The interaction between IL-17 and gut microbiota contributes to cholestatic liver disease in children
The pathogenesis of cholestatic liver disease (CLD) is unknown, but the influence of gut microbiota and inflammation cannot be ignored. In this study, we attempted to provide theoretical insights for ...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · 23d
New paper alert! Another good read from @webberma.bsky.social. Different food preservatives induce similar responses in Salmonella typhimurium, including oxidative stress responses. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Common food preservatives induce an oxidative stress response in Salmonella enterica serovar Typhimurium
Despite their frequent use, the mechanisms of action of common food preservatives are poorly understood. As there is a drive to develop alternative preservatives, understanding the mechanisms of actio...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · 23d
New paper alert! Serial selection for hyper-biofilm production identifies c-di-GMP as central to genetic control and phenotypic dynamics. @microbiologysociety.org @webberma.bsky.social www.microbiologyresearch.org/content/jour...
Cyclic-di-GMP signalling mutants drive ecological succession and self-generated diversity in experimentally evolved biofilms of Pseudomonas aeruginosa
Biofilms represent a discrete form of microbial life which are physiologically distinct from free-living planktonic cells. The altered phenotypic manifestations of the biofilm may also elicit lifestyl...
www.microbiologyresearch.org
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Reposted by apreston243.bsky.social
lucyweinert.bsky.social
Lucy Weinert @lucyweinert.bsky.social · 23d
www.findaphd.com/phds/project...
Investigating pathogenicity in zoonotic Streptococcus suis at University of Cambridge on FindAPhD.com
PhD Project - Investigating pathogenicity in zoonotic Streptococcus suis at University of Cambridge, listed on FindAPhD.com
www.findaphd.com
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apreston243.bsky.social @apreston243.bsky.social · Sep 5
New Primer alert! And now with the correct link, apologies @dezieleric.bsky.social! Microbial Primer on the essentials of biosurfactants. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Microbial Primer: Biosurfactants – the ABCs of microbial surface-active metabolites
Microbial surfactants (biosurfactants) are low-molecular-weight amphiphilic secondary metabolites synthesized by a wide range of micro-organisms, including bacteria, yeasts and fungi. These compounds ...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Sep 5
I think I'd prefer a rejection in seconds compared to one in months from people who clearly haven't read it.
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apreston243.bsky.social @apreston243.bsky.social · Sep 3
New paper alert! Complex interactions between Pseudomona aeruginosa and Staph aureus involved in tolerance to silver of Staph. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Role of AprA and pyocyanin from Pseudomonas aeruginosa on Staphylococcus aureus tolerance to silver
The opportunistic pathogens Staphylococcus aureus and Pseudomonas aeruginosa are often found together causing persistent infections where they exhibit complex interactions that affect their virulence ...
www.microbiologyresearch.org
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Reposted by apreston243.bsky.social
alanmcn1.bsky.social
Alan McNally @alanmcn1.bsky.social · Sep 3
We have a position for an Assist Prof in Microbial Genomics in our School of III.

Hod Joan Geoghegan will be happy to field questions if you are interested. No specific area of microbial genomics preferred so please do consider it

www.jobs.ac.uk/job/DOO184/a...
Assistant Professor (Research and Education) in Bacterial Genomics at University of Birmingham
Apply now for the Assistant Professor (Research and Education) in Bacterial Genomics role on jobs.ac.uk - the leading job board for higher education jobs. View details.
www.jobs.ac.uk
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apreston243.bsky.social @apreston243.bsky.social · Sep 3
New paper alert! Nice insight into the basis for the toxicity of environmental saturated fatty acids towards Enterococcus faecalis. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Enterococcus faecalis requires unsaturated fatty acids to overcome toxicity of environmental saturated fatty acids
Enterococcus faecalis synthesizes phospholipids from either de novo synthesized or exogenous fatty acids. However, environmental saturated fatty acids are toxic to E. faecalis. The mechanism of toxici...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Sep 2
New paper alert! Novel insight into regulation of Staph aureus toxicity by phosphate via PhoPR, including a role for the unphosphorylated response regulator. @microbiologysociety.org @masseylab.bsky.social www.microbiologyresearch.org/content/jour...
Phosphate sensing by PhoPR regulates the cytotoxicity of Staphylococcus aureus
Staphylococcus aureus has evolved a complex regulatory network to coordinate expression of virulence factors, including cytolytic toxins, with host environmental signals. Central to this network are t...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Sep 1
Fantastic PhD project available (I'm biased obviously) with me and the wonderful Stefano Pagliara at Exeter and @jodymmason.bsky.social at Bath. Bioinformatics, metabolic modelling, single cell imaging and new antibiotics. Who could want more? Apply now! gw4biomed.ac.uk/bacterial-hu...
Bacterial Hunger Games: Targeting Nutrient Transport for Novel Antibiotic Development - GW4 BioMed MRC DTP
Project Code MRCIIAR26Ba Preston Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Most current antibiotics are derivatives ...
gw4biomed.ac.uk
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apreston243.bsky.social @apreston243.bsky.social · Sep 1
New paper alert! Selective TLO gene families are required for expression of Tac-1 mediated fluconazole resistance in Candida albicans. Towards understanding drug resistance in this important pathogen. @microbiologysociety.org @gazmoran.bsky.social www.microbiologyresearch.org/content/jour...
Fluconazole resistance and CDR1 expression in Candida albicans mediated by the hyperactive Tac1-5 transcriptional activator requires Tlo proteins
Candida albicans is an opportunistic fungal pathogen associated with superficial and systemic infections in humans. Azole antifungal resistance in C. albicans is of clinical concern, and both oral and...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Sep 1
Fantastic PhD project available (I'm biased obviously) with me and the wonderful @PagliaraExeter and @JodyMMason. Bioinformatics, metabolic modelling, single cell imaging and new antibiotics. Who could want more? Apply now! gw4biomed.ac.uk/bacterial-hu...
Bacterial Hunger Games: Targeting Nutrient Transport for Novel Antibiotic Development - GW4 BioMed MRC DTP
Project Code MRCIIAR26Ba Preston Project Type Wet lab Research Theme Infection, Immunity, Antimicrobial Resistance and Repair Project Summary Download Summary Most current antibiotics are derivatives ...
gw4biomed.ac.uk
apreston243.bsky.social @apreston243.bsky.social · Aug 26
New paper alert. Insight into metabolic shifts in response to temperature in marine strains of Rhodococcus. Implications for mining the biochemistry of rare Actinomycetes. @microbiologysociety.org @kateduncan.bsky.social www.microbiologyresearch.org/content/jour...
Assessing the effect of temperature on Rhodococcus metabolite production
Rare actinomycetes are increasingly recognised as a valuable yet underexplored source of bioactive compounds with significant biomedical potential. While it is well established that bacteria have evol...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Aug 26
New paper alert! Toxins can skew the results of competition assays, fascinating short communication from @prokaryota.bsky.social and @willpjsmith.bsky.social. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Type VI secretion system activity at lethal antibiotic concentrations leads to overestimation of weapon potency
Competition assays are a mainstay of modern microbiology, offering a simple and cost-effective means to quantify microbe–microbe interactions in vitro. Here, we demonstrate a key weakness of this meth...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Aug 26
New paper alert! Resistance to phage in Paenibacillus larvae comes at a cost. Important consideration for developing phage therapy to tackle foul brood. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Bacteriophage resistance evolution in a honey bee pathogen
Honey bee (Apis mellifera) larvae are susceptible to the bacterial pathogen Paenibacillus larvae, which causes severe damage to bee colonies. Antibiotic treatment requires veterinary supervision in th...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Aug 18
New paper alert! CRP is co-opted to regulate expression of virulence genes in enteroaggregative E. coli, linking virulence state to metabolism. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Genome-wide mapping of cAMP receptor protein binding in enteroaggregative Escherichia coli reveals targeting of virulence-associated genes
Bacterial pathogens employ a diverse array of virulence factors to colonize and subsequently elicit disease in their host. These factors are often subject to extensive regulation at the transcriptiona...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Aug 15
New paper alert! A tick defensin, persulcatsuin, augments antibiotic effect against Staph aureus. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
The combined effects of tick defensin persulcatusin with conventional antibiotics and antimicrobial proteins/peptides against Staphylococcus aureus
Persulcatusin (IP) is a tick defensin isolated from Ixodes persulcatus and is composed of 38 aa (molecular weight of 4,200). IP exhibits potent antimicrobial activity against Staphylococcus aureus, in...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Aug 5
New paper alert! Engineered GarA increases erythromycin production from Saccharopolyspora erythraea. Metabolic engineering for antibiotic production. @microbiologysociety.org www.microbiologyresearch.org/content/jour...
Engineering the TCA cycle regulator GarA to increase erythromycin production in Saccharopolyspora erythraea
Actinobacteria are important for industrial production of antibiotics, fine chemicals and food and a source of new compounds for drug discovery. Their central metabolism is regulated by a conserved pr...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Aug 4
New paper alert! In depth characterisation of non-encapsulated pneumococci in saliva: stability, detection and recovery. Important findings for using saliva samples for carriage studies. @microbiologysociety.org @annewyllie.bsky.social www.microbiologyresearch.org/content/jour...
Storage stability of non-encapsulated pneumococci in saliva is dependent on null-capsule clade, with strains carrying aliC and aliD showing a competitive disadvantage during culture enrichment
Non-encapsulated Streptococcus pneumoniae (NESp) represent up to 19% of circulating pneumococci and exhibit high rates of genetic exchange and antimicrobial resistance. Saliva is increasingly used as ...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Jul 31
New paper alert! A real time PCR assay to detect and distinguish Klebsiella pneumonia, quasipneumoniae and variicola. @microbiologysociety.org @sylvainbrisse.bsky.social www.microbiologyresearch.org/content/jour...
KpSC-ID: a multiplex real-time PCR assay for the simultaneous detection of the Klebsiella pneumoniae species complex and specific identification of Klebsiella pneumoniae, Klebsiella quasipneumoniae an...
The Klebsiella pneumoniae species complex (KpSC) comprises five closely related bacterial species, namely Klebsiella pneumoniae, Klebsiella quasipneumoniae, Klebsiella variicola, Klebsiella quasivarii...
www.microbiologyresearch.org
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apreston243.bsky.social @apreston243.bsky.social · Jul 31
New paper alert! Flagella mediated adherence of Pectobacterium atrosepticum to potato plants requires flagella motility. @microbiologysociety.org @nicholden.bsky.social www.microbiologyresearch.org/content/jour...
Pectobacterium atrosepticum SCRI1043 flagella mediate adherence to potato plants indirectly through motility
Flagella are widely distributed appendages in bacteria with well-characterized functions in motility and chemotaxis. They also interact directly with hosts and, due to their ubiquity, are potent immun...
www.microbiologyresearch.org
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