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Arcadia Science @arcadiascience.com · 9d

Megan Hochstrasser (@meganhoch.bsky.social)

Free, professional illustrations of research organisms! 🎨🐁🪼🧪 We compiled original vector/raster graphics of 70+ organisms & viruses into a CC0 library. All by @arcadiascience.com's Audrey...

bsky.app

Arcadia Science @arcadiascience.com · 22d

All hardware designs, software, and documentation are open-source and available on GitHub. We'd love your feedback on what features would make AutoOpenRaman more useful for your research! [8/8]

research.arcadiascience.com/pub/resource...

AutoOpenRaman: Low-cost, automated Raman spectroscopy

We developed AutoOpenRaman, an automated, inexpensive microscope for Raman spectroscopy. We recapitulated many features of expensive commercial Raman spectroscopy systems using economical hardware and...

research.arcadiascience.com

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Arcadia Science @arcadiascience.com · 22d

This resource is perfect for scientists who want to try Raman spectroscopy without committing to expensive commercial systems, or current OpenRAMAN users who want to add automation to their experiments. [7/8]

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Arcadia Science @arcadiascience.com · 22d

We demonstrated AutoOpenRaman's capabilities by automatically collecting 200 Raman spectra from Chlamydomonas reinhardtii colonies in 68 minutes across a 96-well plate format. The system successfully detected β-carotene signatures in the algae. [6/8]

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Arcadia Science @arcadiascience.com · 22d

The software is designed for non-programmers to install and use, built on µManager (micro-manager.org) for broad device support. Users can swap hardware components as long as µManager supports them — no code changes needed [5/8]

Diagram of AutoOpenRaman software flow and user interface

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Arcadia Science @arcadiascience.com · 22d

On the hardware side, we added a motorized XY stage, microscope objective, laser shutter, and neon light source for quick calibration. [4/8]

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Arcadia Science @arcadiascience.com · 22d

Our solution: AutoOpenRaman adds automation to OpenRAMAN while keeping it open-source and relatively inexpensive (~$8k in total). [3/8]

Diagrams of the AutoOpenRaman spectrometer setup

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Arcadia Science @arcadiascience.com · 22d

The problem: Commercial Raman systems offer automation, but cost $200k+. #OpenRAMAN (open-raman.org) is a powerful, inexpensive DIY alternative, but it doesn't support automation. [2/8]

OpenRAMAN

open-raman.org

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Arcadia Science @arcadiascience.com · 22d

Introducing AutoOpenRaman, an automated, inexpensive microscope setup for Raman spectroscopy! We recapitulated many features of expensive commercial systems using economical hardware and open-source software 🧵 [1/8]

research.arcadiascience.com/pub/resource...

AutoOpenRaman: Low-cost, automated Raman spectroscopy

We developed AutoOpenRaman, an automated, inexpensive microscope for Raman spectroscopy. We recapitulated many features of expensive commercial Raman spectroscopy systems using economical hardware and...

research.arcadiascience.com

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Arcadia Science @arcadiascience.com · Sep 1

Chlamydomonas cpc1-1 mutant exhibits unexpected growth phenotypes

Comparative analysis of <i>Chlamydomonas </i>strains revealed that a <i>cpc1-1</i> mutant has three unexpected growth phenotypes across different media types, suggesting possible genetic background contributions...

doi.org

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Reposted by Arcadia Science

Seemay Chou @seemaychou.bsky.social · Aug 5

After many yrs building internally @arcadiascience.com we're now able to partner more with others on cool organisms. You won't hurt my feelings if you don't read my post, but don't miss out on our first organismal spotlight animation featuring sea squirts -- just skip to the bottom! 🧵

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Arcadia Science @arcadiascience.com · Aug 5

Our blog is now on Substack! Check out our first post there, which includes a fun video we made about why you might want to study sea squirts open.substack.com/pub/arcadias...

It’s true that no model is perfect, but how can we find ones that are less wrong? We’re excited to announce two research partnerships investigating predicted matches between diseases and research orga...

open.substack.com

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Arcadia Science @arcadiascience.com · Aug 4

AI laboratory for lit review

doi.org

Arcadia Science @arcadiascience.com · Aug 1

New website who dis
www.arcadiascience.com

Arcadia Science

Developing better ways to predict and test therapeutics.

www.arcadiascience.com

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Arcadia Science @arcadiascience.com · Jul 22

Want to give input to help your fellow scientists?

We’ve updated our list of preprints in need of feedback: bit.ly/preprintrequests

We’re having our own preprint commenting event next Friday. We’ll consider reading your work if you add it to the list: bit.ly/submitpreprint

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Arcadia Science @arcadiascience.com · Jun 24

Two Arcadia talks today!

11:15 am — Athena CD — George Sandler
“The potential of machine learning for genomic prediction in a quantitative genetics framework”

11:45 am — Athena F — Ryan York
“Evolution determines what machines can learn”

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Arcadia Science @arcadiascience.com · Jun 23

#ICYMI

Cameron Dale MacQuarrie (@cdmacquarrie.bsky.social)

Discovered some unexpected growth phenotypes in Chlamydomonas flagellar mutants! The cpc1-1 strain (with central pair complex defects) shows surprising metabolic traits that might be independent of its...

bsky.app

Arcadia Science @arcadiascience.com · Jun 23

Calling all scientists! 🚨 Share feedback on preprints that need it! Check out our updated list: bit.ly/preprintrequests

We’re hosting our next internal preprint commenting party this Friday, and might review your work! Submit it here: bit.ly/submitpreprint

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Arcadia Science @arcadiascience.com · Jun 22

As #Evol2025 talks wrap up for the day, our mixer begins!

Come upstairs at The Globe any time til 7:30 to learn about opportunities at Arcadia over charcuterie & drinks 🍷🧀

We’re looking for a Computational Evolutionary Biologist, Evolutionary Cell Biologist, and more…

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Arcadia Science @arcadiascience.com · Jun 22

📢 Hey #Evol2025 attendees, we’re hiring!

If you’re interested in #careers at Arcadia, swing by our free mixer upstairs at The Globe today from 5:30 to 7:30. It’s a 7-minute walk from the Classic Center and drinks are free 🍻

jobs.lever.co/arcadiascience

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Arcadia Science @arcadiascience.com · Jun 22

First Arcadia talk at @evolmtg.bsky.social‬! #Evol2025

Today — 3 pm — Athena CD

Austin Patton presents “Graph neural networks: A unifying predictive model architecture for evolutionary applications”

Arcadia Science @arcadiascience.com · Jun 21

We’re at ‪@evolmtg.bsky.social‬! Follow us for updates on talks as the conference unfolds.

We’re also hosting a free careers mixer 🍺 at The Globe tomorrow @ 5:30 pm — join us!

#Evol2025

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Arcadia Science @arcadiascience.com · May 29

#PubDrop bsky.app/profile/cdma...

Cameron Dale MacQuarrie (@cdmacquarrie.bsky.social)

Discovered some unexpected growth phenotypes in Chlamydomonas flagellar mutants! The cpc1-1 strain (with central pair complex defects) shows surprising metabolic traits that might be independent of its...

bsky.app

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Arcadia Science @arcadiascience.com · May 26

#ICYMI

Arcadia Science (@arcadiascience.com)

One of our scientists whipped up a lit review terminal program where AI agents with different expertise collaboratively discuss #biorxiv and #arxiv preprints 🤖🧪📚 https://github.com/Arcadia-Science/agent-literature-review...

bsky.app

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Reposted by Arcadia Science

Ubadah Sabbagh @ubadahsabbagh.com · May 2

>march 10 @arcadiascience.com announces new form of rapid publishing
>apr 18 team reads a preprint, finds it interesting
>9 work days later, team publishes results validating and extending model

this is how science should be. open, rapid, with the community
arcadia-science.github.io/2025-geno-ph...

Cross-trait learning with a canonical transformer tops custom attention in genotype-phenotype mapping –

arcadia-science.github.io

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