Ariel K. Frame
@arielframe.bsky.social
BSc Biology || PhD Neuroscience || Postdoc with Andrew Lin @andrewclin.bsky.social at University of Sheffield @sheffielduni.bsky.social || Drosophila, aging, learning and memory, neurobiology. Host: linktr.ee/quitecurious bit.ly/ArielFrame_GoogleScholar
Cool finding! @rutterlab.bsky.social do you think the effect of MPC expression on cell size may also be impacted by gain/loss of lactate function? This study comes to mind: www.nature.com/articles/s41... Lactate regulates cell cycle by remodelling the anaphase promoting complex | Nature
Lactate regulates cell cycle by remodelling the anaphase promoting complex - Nature
Discovery of a biochemical mechanism through which lactate binds and inhibits the SUMO protease SENP1, stimulating timed degradation of cell cycle proteins, and resulting in mitotic exit.
www.nature.com
December 5, 2025 at 12:05 AM
Cool finding! @rutterlab.bsky.social do you think the effect of MPC expression on cell size may also be impacted by gain/loss of lactate function? This study comes to mind: www.nature.com/articles/s41... Lactate regulates cell cycle by remodelling the anaphase promoting complex | Nature
Reviewer is told to try shutdown AI algorithmic perfection with unendorsements. This system gets the benefit of AI catching issues with the manuscript the reviewer may not have otherwise and the human has an opportunity to propose ideas outside the mean, which the AI is unlikely to. Only loss: speed
December 4, 2025 at 11:41 PM
Reviewer is told to try shutdown AI algorithmic perfection with unendorsements. This system gets the benefit of AI catching issues with the manuscript the reviewer may not have otherwise and the human has an opportunity to propose ideas outside the mean, which the AI is unlikely to. Only loss: speed
Interesting! Very astute identification of two problems: regression to the mean and algorithmic perfectionism. Potential solution: have AI propose a list of questions, have human reviewer check off the ones they endorse, cancel those they unendorse, then make a list of their own if they have more.
December 4, 2025 at 11:41 PM
Interesting! Very astute identification of two problems: regression to the mean and algorithmic perfectionism. Potential solution: have AI propose a list of questions, have human reviewer check off the ones they endorse, cancel those they unendorse, then make a list of their own if they have more.
Only thing I can think of at the moment is maybe you could use the tubP-FRT-GAL80-FRT we have in Andrew Lin’s lab in combination with a CNS-expressing FLP. I found an Nsyb>FLP flybase.org/reports/FBti... but, I don’t FLP 100% always cuts FRT. so, not sure how to get around that.
FlyBase Insertion Report: Dmel\P{R57C10-FLPL}su(Hw)attP8
FlyBase: a database for drosophila genetics and molecular biology
flybase.org
October 19, 2025 at 3:38 PM
Only thing I can think of at the moment is maybe you could use the tubP-FRT-GAL80-FRT we have in Andrew Lin’s lab in combination with a CNS-expressing FLP. I found an Nsyb>FLP flybase.org/reports/FBti... but, I don’t FLP 100% always cuts FRT. so, not sure how to get around that.
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July 25, 2025 at 11:41 PM
Music by freebeats.io produced by White Hot