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Artem Nemudryi

@artemnemudryi.bsky.social

73 followers 140 following 9 posts

Assistant Professor at University of Florida College of Medicine

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Artem Nemudryi @artemnemudryi.bsky.social · Jul 25

First preprint from the Nemudryi Lab! 🍾

In this work, we link antiviral immunity in bacteria and humans by showing that homologs of human Schlafen nucleases protect bacteria from phages.

www.biorxiv.org/content/10.1...

Bacterial Schlafens mediate anti-phage defense

Human Schlafen proteins restrict viral replication by cleaving tRNA, thereby suppressing protein synthesis. Although the ribonuclease domain of Schlafen proteins is conserved across all domains of lif...

www.biorxiv.org

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Artem Nemudryi @artemnemudryi.bsky.social · 21h

Only few weeks left to apply - application deadline is October 31st, 2025.

‼️Please share – our department is looking for new faculty!

The Department of Biochemistry & Molecular Biology @UF is recruiting a tenure-track Assistant Professor☀️🌴

Link to apply ⬇️
explore.jobs.ufl.edu/en-us/job/53...

Artem Nemudryi @artemnemudryi.bsky.social · Aug 18

👇🏽👇🏽👇🏽

Luuk Loeff @lloeff.bsky.social · Aug 18

Exciting times ahead!

Today marks the first day of the Loeff Lab at Leiden University Medical Center in the Netherlands 🇳🇱. I’m thrilled to begin this new adventure and continue exploring microbial defense mechanisms and their applications through an integrative structural biology approach.

Artem Nemudryi @artemnemudryi.bsky.social · Jul 25

@anemudraia.bsky.social and I are grateful to our very first team members, Veronica, Yimo, and Riley, who bravely joined the lab early on and worked hard on this project!

And big thanks to our collaborators, @lloeff.bsky.social and @kirillemedvedev.bsky.social. Excited for what’s next!

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Artem Nemudryi @artemnemudryi.bsky.social · Jul 25

Our work highlights Schlafens as an ancient, mechanistically conserved family of immune effectors, revealing the deep evolutionary origin of tRNA-targeting antiviral immunity in humans.

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Artem Nemudryi @artemnemudryi.bsky.social · Jul 25

We focused on a system, which we named pSlfn5, that senses tail assembly chaperones of T5-like phages and cleaves tRNA, triggering abortive infection.

We show that its sensor domains are modular and can be swapped to engineer phage specificity.

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Artem Nemudryi @artemnemudryi.bsky.social · Jul 25

We found Schlafen nucleases are widespread in prokaryotes, enriched in phage defense islands, and protect bacteria from phage infection.

Prokaryotic Schlafens are fused to diverse domains that likely act as phage sensors and regulate nuclease activity.

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Artem Nemudryi @artemnemudryi.bsky.social · Jul 25

We asked: How deep are the evolutionary roots of Schlafen antiviral tRNA‑cleaving mechanism? 🤔

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Artem Nemudryi @artemnemudryi.bsky.social · Jul 25

Schlafen proteins were discovered in 1998 and named after the German verb for “to sleep” because they induce dormancy when overexpressed in mouse cells.

Among many other functions, mammalian Schlafens restrict viruses by cleaving tRNAs and shutting down translation.

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Artem Nemudryi @artemnemudryi.bsky.social · Jul 25

Bacterial Schlafens mediate anti-phage defense

www.biorxiv.org

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Reposted by Artem Nemudryi

Aude Bernheim @audeber.bsky.social · Jul 24

🦠🧍‍♀️From bacterial to human immunity.

We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity.
Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social

www.science.org/doi/10.1126/...

www.science.org

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