Tianshuo Liu
@arthurliu43.bsky.social
Timely for #RNA25 #RNA2025! Our new paper reveals a de novo inhibitor for a large #RNA ribozyme in Candida albicans. With Ling Xu & Kevin Chung, we detail structural insights into its mechanism (PDB: 9MQT🤩). Opens avenues for RNA-targeting drug discovery! Check it out: www.pnas.org/doi/full/10.....
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
May 29, 2025 at 2:30 AM
Timely for #RNA25 #RNA2025! Our new paper reveals a de novo inhibitor for a large #RNA ribozyme in Candida albicans. With Ling Xu & Kevin Chung, we detail structural insights into its mechanism (PDB: 9MQT🤩). Opens avenues for RNA-targeting drug discovery! Check it out: www.pnas.org/doi/full/10.....
Reposted by Tianshuo Liu
Molecular insights into de novo small-molecule recognition by an intron RNA structure @PNAS.org
Molecular insights into de novo small-molecule recognition by an intron RNA structure
Proceedings of the National Academy of Sciences, Volume 122, Issue 19, May 2025.
SignificanceThe ability to target and regulate RNA function with small molecules has vast potential, but molecular understanding of the metrics governing RNA–drug interactions is limited. Here, we present a unified study in which de novo small-molecule ...
dlvr.it
May 21, 2025 at 2:39 AM
Molecular insights into de novo small-molecule recognition by an intron RNA structure @PNAS.org