arvoiovs.bsky.social
@arvoiovs.bsky.social
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arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 9h
Marie-Louise Munch Bøegh et al. from Zealand University Hospital investigate vagal nerve function and correlation to CD4+ T-cell population in patients with neovascular age-related macular degeneration (nvAMD) and healthy individuals.
doi.org/10.1167/iovs.66.13.16
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 9h
Yusuke Murakami et al. from Kyushu University describe a preclinical evaluation of pitavastatin nanoparticles for preserving cone photoreceptors in mouse models of RP.
doi.org/10.1167/iovs.66.13.15
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 9h
Anna Franziska Köller, Frank Schmitz et al. from Saarland University investigate alterations of photoreceptor synaptic ribbons in the retina of a human patient with oculocutaneous albinism type 1 (OCA1).
doi.org/10.1167/iovs.66.13.14
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 9h
Pei-Lung Chen, Ta-Ching Chen et al. from National Taiwan University enhance the molecular diagnosis of inherited retinal degeneration (IRD) by systematically identifying pathogenic splicing variants and characterizing their transcript-level consequences.
doi.org/10.1167/iovs.66.13.12
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 9h
Linxin Xie, et al. from Shandong First Medical University perform comparative transcriptomic profiling of corneal compartments using single-cell and single-nucleus sequencing.
doi.org/10.1167/iovs.66.13.11
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 2d
ason Comander et al. from Massachusetts Eye & Ear describe higher throughput assays for understanding the pathogenicity of variants of unknown significance in the RPE65 gene.
doi.org/10.1167/iovs.66.13.10
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arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 2d
Chenglong Yu et al. from Monash University develop and validate polygenic scores for retinal vessel calibers.
doi.org/10.1167/iovs.66.13.9
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 5d
Siqi Xiong, Xiaobo Xia et al. from Xiangya Hospital find that the Transcription Factor Islet-1 Regulates Diabetes-Induced Inner Blood-Retinal Barrier Disruption.
doi.org/10.1167/iovs.66.13.8
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 5d
Brian P. Brooks et al. from the National Eye Institute find that transgene-induced chromosomal rearrangement with aberrant human vascular endothelial growth factor at the optic fissure leads to uveal coloboma in mice.
doi.org/10.1167/iovs.66.13.7
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 5d
Jong-Su Park, Chuanyu Guo & Xiangyun Wei from the University of Pittsburgh investigate the role of Crumbs2b in cone coalescence via planar orientational cell adhesions in zebrafish.
doi.org/10.1167/iovs.66.13.6
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 7d
Noelia Ruzafa et al. from the University of the Basque Country characterize the most resistant and vulnerable retinal ganglion cell subtypes in a chronic model of glaucoma in rats.
doi.org/10.1167/iovs.66.13.5
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 7d
Aman George et al. from the National Eye Institute @NatEyeInstitute find that TYROSINASE-deficient human retinal pigment epithelium exhibits melanosome maturation defects.
doi.org/10.1167/iovs.66.13.4
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 7d
Danli Shi et al. from Hong Kong Polytechnic University develop a deep learning algorithm for extracting features of choroidal vasculature from angiography images via a human-in-the-loop strategy and explore their relationship with multiple diseases.
doi.org/10.1167/iovs.66.13.3
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arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 7d
Lisa Brennan, Joshua Disatham & Marc Kantorow from Florida Atlantic University find that hypoxia-driven histone modifications govern gene regulation for mature eye lens formation.
doi.org/10.1167/iovs.66.13.2
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 7d
Cintia S. de Paiva et al. from the Cullen Eye Institute show how aging affects lipid homeostasis in lacrimal glands by upregulating lipogenesis and changing its specificity.
doi.org/10.1167/iovs.66.13.1
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 8d
Pascal-Raphael Blersch from Universitätsklinikum Erlangen investigate the efficacy of combining hyperthermic treatments with chemotherapeutics, such as cisplatin, docetaxel, & mitoxantrone, to develop better therapies for specific melanoma subtypes.
doi.org/10.1167/iovs.66.12.71
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 8d
Masuko Ushio-Fukai, Tohru Fukai et al. from the Medical College of Georgia investigate the novel role of copper transporter CTR1 and therapeutic potential of copper chelators in retinal ischemia-reperfusion injury.
doi.org/10.1167/iovs.66.12.70
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 8d
Qingjiong Zhang, Wenmin Sun et al. from Zhongshan Ophthalmic Center investigate the pigmentation pattern of iris and fundus in 75 Chinese families with GPR143-associated ocular albinism.
doi.org/10.1167/iovs.66.12.69
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 8d
Gregor S. Reiter et al. from the Medical University of Vienna use deep learning to evaluate the impact of disease-specific biomarkers on pointwise sensitivity in patients with active neovascular AMD using two microperimetry instruments.
doi.org/10.1167/iovs.66.12.68
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arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 9d
Shan Huang et al. from Zhongshan Ophthalmic Center explore the role and mechanism of peroxisome proliferator-activated receptor γ coactivator 1-α (PGC1A), a key mitochondrial regulator, in epithelial-mesenchymal transition of lens epithelial cells.
doi.org/10.1167/iovs.66.12.67
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 9d
Yilei Shao, Fan Lu et al. from Wenzhou Medical University investigate regional variations in choroidal parameters and to assess whether intraocular symmetry can aid in identifying pathological myopia.
doi.org/10.1167/iovs.66.12.66
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 12d
Xiaobo Xia, Mengling You et al. from Xiangya Hospital evaluate the neuroprotective role of resveratrol and underlying mechanisms in retinal ischemia/reperfusion injury.
doi.org/10.1167/iovs.66.12.63
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 12d
Maria Vittoria Cicinelli et al. from Vita-Salute San Raffaele University characterize central bouquet hemorrhages (CBHs) in retinal vein occlusion (RVO) and evaluate their association with long-term visual and anatomical outcomes.
doi.org/10.1167/iovs.66.12.62
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 13d
Ursula Schlötzer-Schrehardt from Friedrich-Alexander University establish an advanced In vitro model for pseudoexfoliation syndrome and glaucoma.
doi.org/10.1167/iovs.66.12.61
arvoiovs.bsky.social
arvoiovs.bsky.social @arvoiovs.bsky.social · 13d
Patrice Tankam et al. from Indiana University describe a novel self-referenced optical coherence microscope (OCM) to longitudinally evaluate age-dependent and FECD-dependent changes in DM thickness in mice.
doi.org/10.1167/iovs.66.12.60