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aspneph.bsky.social @aspneph.bsky.social · 2d

Review: Defining Disease Modification in IgA Nephropathy: Toward a Paradigm Shift in Management

Defining Disease Modification in IgA Nephropathy: Toward a Paradigm Shift in Management

Immunoglobulin A nephropathy is a rare, chronic, immune-mediated kidney disease characterized by a slow, progressive decline in kidney function. As a disease without an existing cure, and a leading…

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aspneph.bsky.social @aspneph.bsky.social · 3d

Estimating Glomerular Filtration Rate in Young Persons with Obesity or Diabetes and Hyperfiltration
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Estimating Glomerular Filtration Rate in Young Persons with Obesity or Diabetes and Hyperfiltration

Glomerular filtration rate (GFR) is a key clinical measure for assessing kidney function and aid in the diagnosis of chronic kidney disease (CKD).[1] However, the process required to determine…

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aspneph.bsky.social @aspneph.bsky.social · 3d

APOL1 G1/G2 variants associated with CKD in Afro-Brazilians
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APOL1 G1/G2 variants associated with CKD in Afro-Brazilians

Chronic kidney disease (CKD) affects over 850 million people globally and disproportionately impacts individuals of African ancestry1. In addition to socioeconomic disparities, APOL1 alleles (G1 and…

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aspneph.bsky.social @aspneph.bsky.social · 4d

Urinary leukotriene E4 for predicting steroid sensitivity in children with nephrotic syndrome: an observational cohort study

Urinary leukotriene E4 for predicting steroid sensitivity in children with nephrotic syndrome: an observational cohort study - Pediatric Nephrology

Background Nephrotic syndrome (NS) is a common pediatric kidney disorder characterized by proteinuria, hypoalbuminemia, and edema. Leukotrienes (LTs), as inflammatory mediators, may contribute to NS…

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aspneph.bsky.social @aspneph.bsky.social · 4d

Review: Endpoint selection in autosomal dominant polycystic kidney disease clinical trials
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Endpoint selection in autosomal dominant polycystic kidney disease clinical trials

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the leading hereditary cause of kidney failure. Challenges have arisen in developing consensus-based clinical trial endpoints endorsed by the…

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aspneph.bsky.social @aspneph.bsky.social · 4d

Macrophages mediate acute kidney allograft rejection via a toll-like receptor 4-dependent mechanism

Macrophages play an important role in acute renal allograft rejection (RAR). Here we report that macrophages mediate acute RAR via a toll-like receptor 4 (TLR4)-dependent mechanism.

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aspneph.bsky.social @aspneph.bsky.social · 5d

Impact of urinary extravasation in posterior urethral valves: clinical implications of urinomas and ascites on kidney function

Impact of urinary extravasation in posterior urethral valves: clinical implications of urinomas and ascites on kidney function - Pediatric Nephrology

Background Urinary extravasation (UE) in patients with posterior urethral valves (PUV), in the form of urinomas or urinary ascites, is thought to represent a pop-off mechanism. Previous literature…

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aspneph.bsky.social @aspneph.bsky.social · 5d

Syntaxin 3 regulates apical membrane integrity in proximal tubule epithelial cells and prevents Fanconi syndrome development

Epithelial cell polarity is crucial for the proper functioning of various organs, including the kidneys. Syntaxin 3, a key molecule in membrane-vesicle fusion, is localized in the apical membrane of…

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aspneph.bsky.social @aspneph.bsky.social · 5d

Patient anti-PLA2R1 autoantibodies cause membranous nephropathy in human PLA2R1 transgenic mice
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Patient anti-PLA2R1 autoantibodies cause membranous nephropathy in human PLA2R1 transgenic mice

The discovery of anti-phospholipase A2 receptor 1 (PLA2R1) autoantibodies in patients with membranous nephropathy (MN) has led to a paradigm change in diagnosis, monitoring, risk prediction, and…

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aspneph.bsky.social @aspneph.bsky.social · 5d

Review: Optimizing symptom management in people with kidney failure

Optimizing symptom management in people with kidney failure

People with kidney failure experience high symptom burden, which is associated with an increased risk of mortality, morbidity, and impaired quality of life. Symptoms are often severe and persistent,…

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aspneph.bsky.social @aspneph.bsky.social · 6d

Mineralocorticoid receptor inhibition in parietal epithelial cells prevents focal segmental glomerulosclerosis and crescentic glomerulonephritis.

Focal segmental glomerulosclerosis (FSGS) is a common histological lesion in adults worldwide. It results from initial podocyte injury, followed by a maladaptive activation of glomerular parietal…

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aspneph.bsky.social @aspneph.bsky.social · 6d

Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis
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Critical role of transcription factor SOX4 in tubular epithelial cell dedifferentiation and fibroblast activation during kidney fibrosis

Chronic kidney disease (CKD) is a widely prevalent health issue globally. A striking pathological feature of CKD is kidney fibrosis characterized by excessive production and deposition of…

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aspneph.bsky.social @aspneph.bsky.social · 6d

Kidney injury and colocalization of complement C3, IgA, and IgG in glomerular immune-complex deposits of patients with IgA nephropathy or IgA vasculitis with nephritis.
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Kidney injury and colocalization of complement C3, IgA, and IgG in glomerular immune-complex deposits of patients with IgA nephropathy or IgA vasculitis with nephritis.

IgA nephropathy (IgAN) and IgA vasculitis-with-nephritis (IgAVN) are considered similar diseases with different spectra of clinical manifestations. Routine immunofluorescence microscopy of…

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aspneph.bsky.social @aspneph.bsky.social · 6d

Impact of Age-3 Urine Screening on Diagnosis and Treatment Timing in #Alport Syndrome
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Impact of Age-3 Urine Screening on Diagnosis and Treatment Timing in Alport Syndrome

Alport syndrome is an inherited kidney disease that leads to end-stage kidney disease (ESKD) owing to pathogenic variants in COL4A3/4/5, which encode type IV collagen. Promptly identifying patients…

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aspneph.bsky.social @aspneph.bsky.social · 6d

Review: Advances in computational nephropathology
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#AI

Advances in computational nephropathology

Pathology relies on pathologists’ qualitative assessment and semiquantitative measures to characterize the structural and molecular alterations of tissues. Novel analytical methods and recent…

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aspneph.bsky.social @aspneph.bsky.social · 7d

Case report: Emphysematous pyelonephritis and infection-related calculi

Emphysematous pyelonephritis and infection-related calculi - Pediatric Nephrology

Emphysematous pyelonephritis (EPN) is a critical and life-threatening necrotizing urinary tract infection, marked by gas formation within the renal parenchyma, collecting system or peri-nephric…

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aspneph.bsky.social @aspneph.bsky.social · 7d

Urinary periostin as a novel non-invasive #biomarker for kidney scarring in pediatric vesicoureteral reflux patients

Urinary periostin as a novel non-invasive biomarker for kidney scarring in pediatric vesicoureteral reflux patients - Pediatric Nephrology

Background Vesicoureteral reflux (VUR) is a common pediatric urological condition associated with kidney scarring, which can lead to hypertension, proteinuria, and chronic kidney disease. Current…

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aspneph.bsky.social @aspneph.bsky.social · 7d

Review: New prognostic markers for IgA nephropathy in children

New prognostic markers for IgA nephropathy in children - Pediatric Nephrology

IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide, with significant implications for adults and children. The disease progresses variably, from asymptomatic hematuria to severe…

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aspneph.bsky.social @aspneph.bsky.social · 7d

Correlation between polymorphisms of the aquaporin-1 gene and peritoneal function in children on chronic peritoneal dialysis

Correlation between polymorphisms of the aquaporin-1 gene and peritoneal function in children on chronic peritoneal dialysis - Pediatric Nephrology

Background Aquaporins (AQPs) are a class of proteins that transport water molecules across membranes, which can promote water transport in cells. We aimed to explore the correlation between different…

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aspneph.bsky.social @aspneph.bsky.social · 8d

Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants
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Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants - Pediatric Nephrology

Background Measures of early postnatal fluid balance may be associated with severe intraventricular hemorrhage (sIVH) and/or death in extremely preterm infants in the first postnatal week. Methods A…

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aspneph.bsky.social @aspneph.bsky.social · 8d

A 1-year-old boy with MIRAGE syndrome and nephrotic syndrome, whose kidney histopathology revealed membranous nephropathy-like findings: a case report

A 1-year-old boy with MIRAGE syndrome and nephrotic syndrome, whose kidney histopathology revealed membranous nephropathy-like findings: a case report - Pediatric Nephrology

MIRAGE syndrome is a rare multisystem disorder caused by gain-on-function SAMD9 variants. Kidney biopsies in some MIRAGE syndrome patients have shown glomerular sclerosis or interstitial nephritis. A…

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aspneph.bsky.social @aspneph.bsky.social · 8d

Adequacy and safety of pediatric native kidney biopsy using 16- and 18-gauge needles

Adequacy and safety of pediatric native kidney biopsy using 16- and 18-gauge needles - Pediatric Nephrology

Background The native kidney biopsy is an important diagnostic procedure in pediatric nephrology. Recent meta-analyses did not find the size of the needle as a risk factor for bleeding complications,…

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aspneph.bsky.social @aspneph.bsky.social · 8d

Comparison of different equations for estimating the glomerular filtration rate in pediatric kidney transplant recipients
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Comparison of different equations for estimating the glomerular filtration rate in pediatric kidney transplant recipients - Pediatric Nephrology

Background Accurate glomerular filtration rate estimation (eGFR) is essential for managing pediatric kidney transplant recipients. Given the physiology of pediatric patients receiving adult-donor…

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aspneph.bsky.social @aspneph.bsky.social · 22d

We are pleased to announce the release of the ASPN Annual Report for April 2024 to April 2025. This report highlights the Society’s progress, committee achievements, and ASPN's significant impact over the past year. buff.ly/cjddrY3

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aspneph.bsky.social @aspneph.bsky.social · 23d

Effects of Dapagliflozin on Progression of Chronic Kidney Disease According to Different Rates of Pre-Trial Progression

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