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Reposted by Audald Lloret-Villas

Lluis Montoliu @lluismontoliu.bsky.social · Aug 24

Este verano visitamos Cambridge, con su universidad y centros de investigación referentes en biología molecular. Donde trabajó Fred Sanger, ganador de 2 premios Nobel de Química. Un investigador singular e irrepetible. Te lo explico en mi blog @naukas.bsky.social
montoliu.naukas.com/2025/08/24/u...

Un tipo llamado Fred Sanger - Gen-Ética

Este verano hemos pasado unos días en Cambridge (Reino Unido), ciudad universitaria por excelencia y sede de prestigiosos e históricos centros de investigación. Estos centros convierten a Cambridge en...

montoliu.naukas.com

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Audald Lloret-Villas @audald.bsky.social · 4d

💡 Bonus: Open Snakemake pipelines for both simulation and imputation are provided:
- github.com/vibaotram/si...
- github.com/vibaotram/im...

Feel free to test and optimize imputation strategies for your own datasets before committing to large-scale LCS projects.

GitHub - vibaotram/simulation

Contribute to vibaotram/simulation development by creating an account on GitHub.

github.com

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Audald Lloret-Villas @audald.bsky.social · 4d

💥 Downstream impact:
- PopGen analyses (relatedness, population structure) were congruent with imputation accuracy and depend on genetic relatedness.
- Inbreeding coefficient estimates were more sensitive to imputation.
- Demographic analysis on imputed data showed similar results across the tools.

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Audald Lloret-Villas @audald.bsky.social · 4d

🔑 Choosing your imputation tool:
- All tools worked well in highly related populations.
- Accuracy varied in populations with low relatedness, but GLIMPSE2 & QUILT2 generally outperformed the other tools.
- STITCH is useful when no reference panel exists but results in some missing data.

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Audald Lloret-Villas @audald.bsky.social · 4d

👩🏻‍💻 We tested 5️⃣ imputation methods (GLIMPSE2, GeneImp, QUILT2, STITCH, Beagle5.4), simulated realistic populations with different genetic structures, and applied the methods to data from 283 wild hihi (stitchbird) 🧬.

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Audald Lloret-Villas @audald.bsky.social · 4d

We explored that in this new study in Molecular Ecology Resources 🔎

onlinelibrary.wiley.com/doi/10.1111/...

@vbtram.bsky.social
@huizhentan.bsky.social
@katarinastuart.bsky.social
@annasanture.bsky.social

Assessing Genotype Imputation Methods for Low‐Coverage Sequencing Data in Populations With Differing Relatedness and Inbreeding Levels

Low-coverage sequencing (LCS) followed by genotype imputation has become a cost-efficient approach for obtaining whole-genome SNPs. Several imputation methods for LCS data have been developed over th....

onlinelibrary.wiley.com

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Audald Lloret-Villas @audald.bsky.social · 4d

Low-coverage sequencing (LCS) + genotype imputation is a cost-effective approach to genotype hundreds of samples at a full-genome level. But how do different imputation tools perform across populations with varying relatedness and inbreeding?

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Wikimedia Aotearoa New Zealand @wikimediaaotearoa.bsky.social · 9d

Aotearoa, meet your 2025 Bird of the Year 👑🦅

The kārearea or New Zealand falcon is our only species of falcon, and has reclaimed the top spot once again after its last victory in 2012 🏆

Learn more about this endemic bird of prey ⬇️
w.wiki/FUGN

📷: Tony Wills, CC BY-SA 3.0 #BirdOfTheYear

A male New Zealand Falcon perched on a branch at Zealandia wildlife sanctuary. Wellington, New Zealand

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Reposted by Audald Lloret-Villas

EvolDir @evoldir.bsky.social · 11d

UCPH seeks a postdoc in Water Buffalo Population Genomics, starting Jan 2026. Applicants need a PhD in related fields, programming skills, & experience with… https://candidate.hr-manager.net/ApplicationInit.aspx/?cid=1307&departmentId=18965&ProjectId=164930&MediaId=5&SkipAdvertisement=false #postdoc

Postdoctoral Fellowship in Water Buffalo Population Genomics

The Department of Biology, Faculty of Science at University of Copenhagen is offering a post doc position to work on population genomic analyses in water buffal

candidate.hr-manager.net

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Reposted by Audald Lloret-Villas

Matthew Hahn @3rdreviewer.bsky.social · 12d

Scientists, DON'T USE LaTeX UNLESS ABSOLUTELY NECESSARY, DON'T GIVE LaTeX TO YOUR YOUNG CHILD FOR VIRTUALLY ANY REASON, BREAK UP THE .tex DOC INTO THREE TOTALLY SEPARATE DOCS (NOT MIXED!), TAKE [Underfull \vbox (badness 10000) has occurred]

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Jente Ottenburghs | Avian Hybrids @jenteo.bsky.social · 13d

Nice SciShow-video with many examples of studies using "fake birds" (i.e. decoys or dummies). #ornithology
www.youtube.com/watch?v=aSzC...

These Birds Aren’t Real

YouTube video by SciShow

www.youtube.com

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Audald Lloret-Villas @audald.bsky.social · 23d

☀️ My Mediterranean summer has come to an end, and today I’m kicking off a new postdoctoral adventure in @hernmoral.bsky.social’s group at the Globe Institute! Lots to learn, lots to contribute, and hopefully lots more posting here about Evolutionary & Conservation Genomics 🚀

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Reposted by Audald Lloret-Villas

Mick Westbury @mick2474.bsky.social · 29d

🦣🍖🧬 Fully funded 3-yr PhD in palaeogenomics & bioinformatics! Help me push non-model palaeogenomes beyond their limits @DTU in Denmark.

Start: Feb 2026 (flexible)
Application deadline: 24 Oct 2025

For details click here: tinyurl.com/BioExtPhD

Reposts appreciated 😁

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giaranega.bsky.social @giaranega.bsky.social · Aug 25

1/10 We are thrilled to announce that our new paper on conservation genomics of the Balearic shearwater has just been published online at @pnas.org! www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Reposted by Audald Lloret-Villas

Hui Zhen Tan @huizhentan.bsky.social · Sep 3

Genomic imputation can boost dataset quality and benefit research on wild populations. In hihi, we found high #imputation accuracies despite a small reference panel of high-fecundity individuals. Imputation improves downstream #ConservationGenomics analyses. onlinelibrary.wiley.com/doi/10.1111/...

High Imputation Accuracy Can Be Achieved Using a Small Reference Panel in a Natural Population With Low Genetic Diversity

Genotype imputation, the inference of missing genotypes using a reference set of population haplotypes, is a cost-effective tool for improving the quality and quantity of genetic datasets. Imputation...

onlinelibrary.wiley.com

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Reposted by Audald Lloret-Villas

Ryan Gutenkunst @ryangutenkunst.bsky.social · Aug 21

Me promoting the Genomic History Inference Strategies Tournament at #eseb2025! ghi.st
Population geneticists: join, compete, earn cash, become an author, learn, help the community! ghi.st

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Audald Lloret-Villas @audald.bsky.social · Aug 21

Will be presenting our work on imputation of lcWGS in populations with a range of relatedness and inbreeding. Find me throughout the day at #ESEB2025 (board 337)

Dr. Tram Vi, @annasanture.bsky.social and colleagues (@aucklanduni.bsky.social)

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Audald Lloret-Villas @audald.bsky.social · Aug 18

Back home for a good reason 💁🏻‍♂️
#ESEB2025

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Audald Lloret-Villas @audald.bsky.social · Jul 10

Dr. Tram Vi presented yesterday her fantastic work on imputation of lcWGS in population analyses, in which I had the chance to participate (w/ @annasanture.bsky.social and colleagues). #GSA2025

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Audald Lloret-Villas @audald.bsky.social · Jul 10

I had the chance to talk about this work (part of my postdoc in @susanneppfeifer.bsky.social’ group) at #GSA2025

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Audald Lloret-Villas @audald.bsky.social · Jul 9

As seen in @huizhentan.bsky.social’ presentation - all credit to her!

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Audald Lloret-Villas @audald.bsky.social · Jul 8

The actual PopGen Power Rangers were revealed at the #GSA2025

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Audald Lloret-Villas @audald.bsky.social · Jul 6

First chilly jog in Tāmaki Makaurau / Auckland and ready for the #GSA2025 - @geneticsaus.bsky.social

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Genetics Society of AustralAsia @geneticsaus.bsky.social · Jul 4

Just three more sleeps until #GSA2025 kicks off in Tāmaki Makaurau/Auckland!

Bring your love of science, your curiosity, and maybe a rain jacket - just in case 🌧️🧬

We can't wait to see you there!

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Reposted by Audald Lloret-Villas

Jente Ottenburghs | Avian Hybrids @jenteo.bsky.social · May 19

✍ New blog post: The World Is Falling Apart, But You Don't Have To Follow
jenteottenburghs.wordpress.com/2025/05/19/t...

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