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Aurélie Carlier @aureliecarlier.bsky.social · Aug 3

This link will take you to a page that’s not on LinkedIn

Aurélie Carlier @aureliecarlier.bsky.social · Aug 3

This study shows that by systematically analyzing and integrating all interacting aspects of the foreign body reaction, in silico modeling can provide valuable insights and complement in vitro and in vivo studies for improved implant safety assessment.

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Aurélie Carlier @aureliecarlier.bsky.social · Aug 3

We also show that feedback interactions can protect the system from pathological outcome by gradually reducing the initial inflammatory input.

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Aurélie Carlier @aureliecarlier.bsky.social · Aug 3

The in silico model incorporates key material-related factors, including immunogenic properties and mechanical mismatch. Predictions align with existing knowledge, showing that material stiffness and tissue progressive stiffening due to increased ECM deposition can exacerbate the FBR.

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Aurélie Carlier @aureliecarlier.bsky.social · Aug 3

Very proud of my PhD student Matilde Marradi at @merln-um.bsky.social on having her first research publication out! 👏 👏 👏

In this study, we constructed a literature-based network of the foreign body reaction and developed it into a semi-quantitative predictive model.

A 🧵:

This link will take you to a page that’s not on LinkedIn

lnkd.in

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Aurélie Carlier @aureliecarlier.bsky.social · Jun 29

Here we used a pig and human dataset to compare six computational models of PD!

More information: doi.org/10.3390/toxi...

doi.org

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Aurélie Carlier @aureliecarlier.bsky.social · Jun 29

However, although several mathematical models have been developed in the past few decades, a direct comparison of the models’ accuracy with respect to predicting in vivo data is needed to further create robust personalized models.

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Aurélie Carlier @aureliecarlier.bsky.social · Jun 29

📢 Publication alert!

Computational models of peritoneal dialysis (PD) are increasingly useful for optimizing treatment in patients with kidney disease requiring dialysis (KDRD).

doi.org

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Aurélie Carlier @aureliecarlier.bsky.social · May 12

@merln-um.bsky.social

Aurélie Carlier @aureliecarlier.bsky.social · May 12

www.aanmelder.nl/163348/home

MDR Annual Meeting 2025 - Home

www.aanmelder.nl

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Aurélie Carlier @aureliecarlier.bsky.social · May 12

Very much looking forward to the annual meeting of the Materials-Driven Regeneration Gravitation program!
Make sure to catch the presentation of my PhD student Matilde Marradi: “Towards predicting implant-induced fibrosis: a computational model of fibroblast-macrophage interaction"!

MDR Annual Meeting 2025 - Home

www.aanmelder.nl

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Aurélie Carlier @aureliecarlier.bsky.social · Apr 24

Our findings highlight the significance of adhesion size, spatial distribution, and lifetime, as well as the diffusion rate of YAP and the rate of YAP binding to adhesions, in modulating YAP phosphorylation levels.

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Aurélie Carlier @aureliecarlier.bsky.social · Apr 24

However, formation of larger adhesions on stiff matrices significantly reduces YAP Y357 phosphorylation. In this study, we explore the dynamic interplay between adhesion properties and YAP phosphorylation with the aim to identify factors that could lead to the experimentally-observed behavior.

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Aurélie Carlier @aureliecarlier.bsky.social · Apr 24

Let's showcase some of our work!

YAP plays an important mechanosignaling role in essential processes such as cell proliferation and apoptosis. Our recent study shows direct recruitment and phosphorylation of YAP (at the Y357 residue) in small adhesions.

pubmed.ncbi.nlm.nih.gov/39233443/

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Reposted by Aurélie Carlier

Aurélie Carlier @aureliecarlier.bsky.social · Feb 23

Hi Bluesky! 👋 I am Aurélie Carlier, associate professor in computational modeling within regenerative medicine at Maastricht University. My lab focuses on a suite of modeling techniques ranging from mechanistic (hypothesis-based) models to empirical (data-driven) models. Let's connect!

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Reposted by Aurélie Carlier

Maastricht University @maastrichtu.bsky.social · Apr 16

1/2: 📢 Universiteiten presenteren vandaag hun zelfregieplan voor internationale instroom. Tegenwicht voor schadelijke wetgeving én TAO — maar zelfs met steun blijven de bezuinigingen draconisch.

Vandaag staakt UM. Zeg NEE tegen de kaalslag in onderwijs & onderzoek! 🟥
🔗 edu.nl/3xhet

#WOInActie

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Aurélie Carlier @aureliecarlier.bsky.social · Apr 15

Very much looking forward to the disease map community meeting! Make sure to catch the talk of my postdoc Leyla Noroozbabaee on "Modeling Toxin-Transporter Dynamics in Chronic Kidney Disease: A Computational and Experimental Framework"

disease-maps.io/DMCM2025/

DMCM2025

Disease Maps Community website

disease-maps.io

Aurélie Carlier @aureliecarlier.bsky.social · Apr 15

📢📢📢 2 more weeks to apply!!

Aurélie Carlier @aureliecarlier.bsky.social · Mar 5

How can we automate the development of digital twins?

Are you ambitious and want to do a PhD?

Join the computational group @merln-um.bsky.social for the
@erc.europa.eu AUTOMATHIC project!

Details below!

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Aurélie Carlier @aureliecarlier.bsky.social · Apr 15

Interested in regenerative medicine? Looking for a bachelor? Join the online session for more information on our unique bachelor program! 👇

MERLN @merln-um.bsky.social · Apr 14

A follow-up 𝗢𝗻𝗹𝗶𝗻𝗲 𝗜𝗻𝗳𝗼𝗿𝗺𝗮𝘁𝗶𝗼𝗻 𝗦𝗲𝘀𝘀𝗶𝗼𝗻 for the 🎓Maastricht BSc Regenerative Medicine and Technology program will be held 𝗼𝗻🗓️𝗔𝗽𝗿𝗶𝗹 𝟭𝟳𝘁𝗵.
Great chance to learn more about the program💡while getting live answers from our experts! 🧑‍🔬

MERLN @merln-um.bsky.social · Apr 3

🎓 Maastricht BSc RMT Program launches its Experience Day on April 9th
We warmly invite you to experience first-hand what our program offers, including a Lab Practical session!
🔗Register now: lnkd.in/e743xsfG
🔗More details: lnkd.in/ewtEY8VM
Can't make it in person? Check this out: lnkd.in/ewcRgMxt

Reposted by Aurélie Carlier

Maastricht University Institute of Data Science @umids.bsky.social · Apr 3

WANTED: System Network Engineer at the Department of Advanced Computing Sciences (DACS), Faculty of Science and Engineering (FSE) at Maastricht University
vacancies.maastrichtuniversity.nl/job/Maastricht-System-Network-Engineer/816337202/

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Aurélie Carlier @aureliecarlier.bsky.social · Apr 3

Interested in regenerative medicine?
Looking for a bachelor?

Search no more 👇!

MERLN @merln-um.bsky.social · Feb 3

🎓Join the One-of-a-Kind Bachelor in Regenerative Medicine and Technology (BSc RMT) at Maastricht University
📅We warmly invite you to our 𝗕𝗮𝗰𝗵𝗲𝗹𝗼𝗿 𝗢𝗽𝗲𝗻 𝗗𝗮𝘆 𝗶𝗻 𝗠𝗮𝗮𝘀𝘁𝗿𝗶𝗰𝗵𝘁 𝗼𝗻 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 𝟴𝘁𝗵!
🔗Register here: lnkd.in/eCxATBXP
🔗For more details: lnkd.in/ewtEY8VM
@maastrichtu.bsky.social

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Aurélie Carlier @aureliecarlier.bsky.social · Mar 26

A bit more than a month left to apply!

Aurélie Carlier @aureliecarlier.bsky.social · Mar 5

How can we automate the development of digital twins?

Are you ambitious and want to do a PhD?

Join the computational group @merln-um.bsky.social for the
@erc.europa.eu AUTOMATHIC project!

Details below!

1

Aurélie Carlier @aureliecarlier.bsky.social · Mar 24

We also identify how different models either explain contradictory experimental observations or generate experimentally testable predictions.

Aurélie Carlier @aureliecarlier.bsky.social · Mar 24

Let's showcase some of our previous research!

doi.org/10.1038/s415...

In this article, we provide a critical review of the current state-of-the-art of computational models that focus on YAP/TAZ signaling.

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Reposted by Aurélie Carlier

MERLN @merln-um.bsky.social · Mar 21

🎉Big congratulations to our postdoc, Dr. Jonathan Briones, on being awarded the MSCA Postdoctoral Fellowships for his research in early human embryogenesis using blastoids derived from pluripotent stem cells, aiming for improving in-vitro fertilization techniques. Bravo!!

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