Waste coffee husks and spent coffee grounds (SCGs) are produced in large qualities worldwide. Characterisation of these waste streams from Australian commercial outlets in terms of lipid, caffeine, an...

N-methylation of cyclic peptides is a widely used strategy to enhance membrane permeability; however, it can also influence metabolic stability. In celebration of Professor David Craik’s scientific ac...

A dibenzimidazolium salt based on binaphthol, 2,2′-bis[2′-(1-ethylbenzimidazole)ethoxy]-1,1′-binaphthol hexafluorophosphate (1) was synthesised. The recognition of compound (1) for Al3+ was studied by...

In this study, four DETA-SiO2 solid amine adsorbents were prepared by an impregnation method using diethylenetriamine (DETA) as the amine source and four types of silica with different pore structures...

Covalent chemical probes form a covalent bond with a target protein of interest to elicit an effect and methods to identify and characterise them are needed. We developed a native mass spectrometry (n...

The endoplasmic reticulum (ER) is the most extensive organelle within eukaryotic cells and functions as a critical hub for cellular biosynthesis. It plays a pivotal role in protein biosynthesis and li...

A symmetric tetramethylcucurbit[6]uril-based porous supramolecular assembly was prepared in an aqueous H2SO4 solution (5 M). The driving force for the formation of this assembly is mainly the outer su...

Successful discovery of potent and selective ligands for therapeutically relevant receptors is indispensable for future clinical applications to treat a wide array of diseases. The mas-related G prote...

An unusual triterpene fatty acid conjugate was isolated from the leaf resin of Dodonaea caespitosa. Its structure was formulated through spectroscopic analysis of the acetylated natural product and it...

In the present study, a new type of material of Zr-TSCD was first synthesized and modified with different amounts of triethylenetetramine (TETA). The properties of the adsorbents were characterised wi...

Facile and concise procedures for the construction of indole fused N-heterocyclic systems were described. A series of benzo-, pyrido-, thieno-, naphtho-fused azepinoindolones and indolo-azepinoquinoli...

Acalypha indica is a herb that grows throughout the tropical regions of the world. As well as being exploited for medicinal use, the roots of this plant are known to elicit a drug-like effect in cats. Recent research into feral cat control on Christmas Island has investigated whether a preparation of the roots of A. indica might be effective in traps to attract feral cats. However, the volatile nature of the attractants made it unviable for use in traps for more than a few days. In this study, we investigated the volatile components emitted by the plant roots and identified two iridoid compounds, (4R,4aR,7S,7aR)-isodihydronepetalactone and (4R,4aS,7S,7aR)-isoiridomyrmecin, which are known to affect behavioural activity in cats. Synthesis of standards confirmed the stereochemistry of both compounds emitted by the plant. Potential application of these compounds in feral cat control is discussed.

Naturally occurring cyclic peptides have emerged as intriguing and relevant scaffolds for next-generation drug design. Especially peptides from the highly constrained cyclotide family provide an excep...

Fluorescent sensors have proved invaluable in elucidating the regulation and dysregulation of redox processes in biology, but understanding of the breadth of biological redox reactions requires develo...

We use the example of textbook treatments of the ‘Rutherford nucleus’ to illustrate the need to avoid conflating important concepts, the ‘brick in the wall’ path to scientific understanding, the value...

The liquid–liquid interface between two immiscible electrolyte solutions (ITIES) offers a unique platform for the formation of nanomaterials, which exhibit redox electrocatalytic activities and enhanc...

Linear free energy relationships (LFERs) are an important topic in physical-organic chemistry. When one browses the literature, one encounters innumerable instances wherein the series in question conf...

The impact of cetylpyridinium chloride (CPC) micelles on RuIII-catalysed oxidation kinetics of L-Tyrosine (L-Tyr) by N-bromosuccinimide (NBS) has been investigated in aqueous medium. The reaction’s pr...

An air- and moisture-tolerant alternate synthetic pathway to the preparation of a cationic chelated bis(NHC) methylpalladium(ii) complex, [{(MesIm)2CH2}Pd(Me)(NCMe)][PF6], is described. The pathway in...

An elegantly simple, facile, and robust approach to a scaffold of biological importance, 2,3-dihydroquinazolin-4(1H)-ones, is reported. A catalytic 1 % SnCl2/microwave-mediated approach afforded acces...

The use of metalloligands as building blocks for the assembly of metallo-organic cages has received increasing attention over the past two decades or so. In part, the popularity of this approach refle...

A novel synthetic route has been designed to introduce fluorine functionality into a series of compounds containing thiazolidin-4-one rings. These compounds were synthesised from various aniline deriv...