Aya Ludin
@ayaludin.bsky.social
Post doc fellow, Zon lab, Harvard. PhD, Weizmann Institute, Israel. A firm believer that the zebrafish natural habitat is under a very good microscope.
Without treatment, CD8+ T cells don't harm tumors too much. But immunotherapy is aimed at activating CD8+ T cells against tumors. When we give immunotherapy these pockets–CRATERs; Cancer Regions of Antigen presentation and T cell engagement and Retention- come alive.
October 18, 2025 at 5:46 PM
Without treatment, CD8+ T cells don't harm tumors too much. But immunotherapy is aimed at activating CD8+ T cells against tumors. When we give immunotherapy these pockets–CRATERs; Cancer Regions of Antigen presentation and T cell engagement and Retention- come alive.
And we found that infiltrating CD8+ T cells don’t just randomly distribute across the tumor. They go into pockets. But they are not stuck there (as we would have thought if it wasn’t a movie). They stay there for many hours interacting with melanoma cells and then move on. How come?
October 18, 2025 at 5:46 PM
And we found that infiltrating CD8+ T cells don’t just randomly distribute across the tumor. They go into pockets. But they are not stuck there (as we would have thought if it wasn’t a movie). They stay there for many hours interacting with melanoma cells and then move on. How come?
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
October 18, 2025 at 5:46 PM
🚨Publication alert: Where does immunotherapy happen? What can the fish teach us about human pathology? And a dendritic cell is having a friend for dinner. Cancer immunology goes live, now in @cp-cell.bsky.social.
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)
Here is a concise summary of a pretty big study 🧵. Let’s go (appetizer👇)