This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry is enabled by the unique properties of cholesterol and endows biomembranes with distinctive properties and physiological roles.

During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could conco...

Cell proliferation is crucial for tissue development. Here, we investigate its role in the Left-Right Organizer (LRO), which establishes the left-right (LR) axis. In zebrafish, we mapped mitotic event...

Cell signaling regulates a wide range of biological processes including development, homeostasis, and disease. Accessible technologies to precisely manipulate signaling have important applications in ...

Cell size is a key contributor to tissue morphogenesis. As a notable example, growth plate hypertrophic chondrocytes use cellular biogenesis and disproportionate fluid uptake to expand 10 to 20 times ...

A reciprocal interaction between gut bacteria and gut cells affects protein absorption in the host.