barbmarte.bsky.social
Barbara Marte
@barbmarte.bsky.social
5.2K followers 950 following 130 posts
Senior Editor @Nature for cancer and cell cycle. Views my own
Posts Media Videos Starter Packs
barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 12d
new out in Nature www.nature.com/articles/s41...
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature
Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 12d
and the News & Views www.nature.com/articles/d41...
A drug–diet combination could improve childhood cancer treatment
Mouse studies show that depriving neuroblastoma of certain amino acids causes a switch in protein synthesis to suppress tumour growth and promote cell differentiation.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 12d
new out in Nature www.nature.com/articles/s41...
Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 12d
and the News & Views www.nature.com/articles/d41...
Boosting immune cells to combat cancer using CRISPR engineering and large-scale in vivo testing
Immune cells can target cancer in the clinic. The ability to test a gene-editing technology in mice on a large scale should improve such immunotherapies.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 12d
new out in Nature www.nature.com/articles/s41...
In vivo CRISPR screens identify modifiers of CAR T cell function in myeloma - Nature
In vivo loss-of-function CRISPR screens were performed to identify genes influencing CAR T cell persistence and function in human multiple myeloma, highlighting CDKN1B as a promising target.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 12d
new out in Nature www.nature.com/articles/s41...
Systematic discovery of CRISPR-boosted CAR T cell immunotherapies - Nature
CELLFIE, a CRISPR platform for optimizing cell-based immunotherapies, identifies gene knockouts that enhance CAR T cell efficacy using in vitro and in vivo screens.
www.nature.com
1
Reposted by Barbara Marte
annettedittert.bsky.social
Annette Dittert @annettedittert.bsky.social · 18d
Will Dunn is right. An awful new trend. Lovely column.
willdunn.bsky.social
Will Dunn @willdunn.bsky.social · 18d
I wrote about the most frightening and dangerous trend in Britain

www.newstatesman.com/comment/2025...
Queueing in pubs disgraces Britain
The practice is unpatriotic and must be banned
www.newstatesman.com
4 6 54
Reposted by Barbara Marte
natmethods.nature.com
Nature Methods @natmethods.nature.com · 19d
We are thrilled to present a special September issue highlighting recent methods in the field of cancer biology.

www.nature.com/articles/s41...
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 18d
this is fun www.nature.com/articles/d41...
Tipsy bats and perfect pasta: Ig Nobels celebrate ‘improbable’ research
The annual awards are a celebration of weird but thought-provoking science.
www.nature.com
4
barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 18d
new out in Nature www.nature.com/articles/s41...
Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer - Nature
Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining neuroendocrine–tuft heterogeneity...
www.nature.com
6
barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 18d
with a bit of delay, a new News & Views out in Nature www.nature.com/articles/d41...
Wired for growth: neuron–tumour signalling in the lung and brain increases growth of a hard-to-treat cancer
Signalling between neurons and tumour cells in the lung and brain promotes the growth of small-cell lung cancer. These interactions might be a therapeutic target.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 27d
2. www.nature.com/articles/s41...
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis - Nature
Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour...
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 27d
and last but not least two cancer neuroscience papers on small cell lung cancer. 1. www.nature.com/articles/s41...
Functional synapses between neurons and small cell lung cancer - Nature
Small cell lung cancer cells form functional synapses with glutamatergic neurons, receiving synaptic transmissions and deriving a proliferative advantage from these interactions.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 27d
new out in Nature www.nature.com/articles/s41...
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours - Nature
An understanding of the molecular mechanisms promoting the generation of immunoregulatory and tumour-promoting monocytes and macrophages is key to breaking the cycle of tumour myelopoiesis and develop...
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 27d
new out in Nature www.nature.com/articles/s41... (the News & Views will come soon)
Molecular subtypes of human skeletal muscle in cancer cachexia - Nature
Unbiased clustering analysis of the skeletal muscle RNAome in patients with cancer identifies two molecular subtypes, one of which distinguishes individuals with cachexia and indicates ...
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 27d
and the News & Views
www.nature.com/articles/d41...
Epigenetic clues from cancer’s past foretell its future
An innovative method to trace tumour evolution using patterns of fluctuating DNA modifications could be implemented in the clinic to predict cancer progression.
www.nature.com
3
barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 27d
new out in Nature www.nature.com/articles/s41...
Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature
Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · 29d
the deadline to register at the inaugural EACR cancer neuroscience is approaching fast: Sept 15th. Do join us for a fantastic line up of invited speakers, short talks and abstracts (yes, we have seen them) in the wonderful city of Bilbao (Guggenheim, Pintxos, Txakoli...). eacr.org/conference/c....
Introduction | Cancer Neuroscience | The European Association for Cancer Research
eacr.org
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · Sep 6
new out in Nature www.nature.com/articles/d41...
Compression causes cancer cells to start spreading
The switch between proliferation and invasion is triggered by mechanical force.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · Sep 6
and the News & Views www.nature.com/articles/d41...
Depriving brain tumours of an amino acid could enhance chemotherapy
Glioblastoma, an aggressive brain cancer, depends on the amino acid serine as a fuel source. A serine-deficient diet has been shown to slow tumour growth in mice.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · Sep 6
new out in Nature www.nature.com/articles/s41...
Rewiring of cortical glucose metabolism fuels human brain cancer growth - Nature
The cortex fuels essential physiological processes with glucose-derived carbon, while gliomas fuel their aggressiveness by rerouting glucose carbon pathways and scavenging alternative carbon sources s...
www.nature.com
2
barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · Aug 29
new out in Nature this week www.nature.com/articles/s41...
Mechanical confinement governs phenotypic plasticity in melanoma - Nature
Mechanical confinement of cancer cells at the tumour–microenvironment interface induces phenotype switching through chromatin remodelling by HMGB2, leading to a more invasive and drug-resistant state ...
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · Aug 21
new out in Nature www.nature.com/articles/s41...
Axonal injury is a targetable driver of glioblastoma progression - Nature
Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.
www.nature.com
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barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · Aug 21
a News & Views on a recent JCO paper www.nature.com/articles/d41...
Immunotherapy using CAR T cells shows promising long-term outcomes for people with the blood cancer myeloma
A clinical trial reports data from one of the first groups of people with the blood cancer myeloma to receive a type of immunotherapy called CAR T cells.
www.nature.com
barbmarte.bsky.social
Barbara Marte @barbmarte.bsky.social · Aug 21
just out this News & Views on a recent NEJM paper
www.nature.com/articles/d41...
Exercise improves survival of some people with colon cancer, clinical trial shows
Most studies on how exercise affects the survival of people with cancer have been observational. A clinical trial provides compelling evidence of the benefits of physical activity.
www.nature.com
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