Barzin
@barzin.sanctus.ca
Iranian-Canadian dude who runs Sanctus.ca and tries to survive other human beings, bro what even is this planet. Works in AI and human biological rejuvenation. Refuses to consider LLMs conscious until they start demanding the Epstein files be released.
Trust me I'm an insider!
September 20, 2025 at 7:20 AM
Trust me I'm an insider!
Fun fact: They're going to replace all these people they're cancelling with Gina Carano and she's going to play all their roles.
She's substituting Jimmy Kimmel, every few episodes we're gonna get an earful about why the MAGA people are the victims of a new holocaust
She's substituting Jimmy Kimmel, every few episodes we're gonna get an earful about why the MAGA people are the victims of a new holocaust
September 20, 2025 at 7:20 AM
Fun fact: They're going to replace all these people they're cancelling with Gina Carano and she's going to play all their roles.
She's substituting Jimmy Kimmel, every few episodes we're gonna get an earful about why the MAGA people are the victims of a new holocaust
She's substituting Jimmy Kimmel, every few episodes we're gonna get an earful about why the MAGA people are the victims of a new holocaust
I'm tempted to celebrate it just to fuck with these assholes to be honest.
September 20, 2025 at 1:18 AM
I'm tempted to celebrate it just to fuck with these assholes to be honest.
That's it. That's the spirit right there.
A-fucking-men.
A-fucking-men.
September 20, 2025 at 1:11 AM
That's it. That's the spirit right there.
A-fucking-men.
A-fucking-men.
If he only killed other far right lunatics I'm not sure I mind..
September 20, 2025 at 1:10 AM
If he only killed other far right lunatics I'm not sure I mind..
Feed it to Gemini CLI and save myself two weeks 🤔
September 20, 2025 at 12:47 AM
Feed it to Gemini CLI and save myself two weeks 🤔
There's a few ideas that can still probably squeeze more juice out of what they made:
- Direct context injection being superior to RAG can create a bit more optimization
- How to optimally separate context and pass them between models
- How the model hierarchy impacts quality of outcomes
- Direct context injection being superior to RAG can create a bit more optimization
- How to optimally separate context and pass them between models
- How the model hierarchy impacts quality of outcomes
September 19, 2025 at 3:27 PM
There's a few ideas that can still probably squeeze more juice out of what they made:
- Direct context injection being superior to RAG can create a bit more optimization
- How to optimally separate context and pass them between models
- How the model hierarchy impacts quality of outcomes
- Direct context injection being superior to RAG can create a bit more optimization
- How to optimally separate context and pass them between models
- How the model hierarchy impacts quality of outcomes
It could be because when you're looking at extremely hard or complex, tangled problems like aging, it helps us as human beings to break the problem down and we haven't been able to meaningfully describe and train LLMs to solve those kinds of problems in one unified model?
September 19, 2025 at 3:27 PM
It could be because when you're looking at extremely hard or complex, tangled problems like aging, it helps us as human beings to break the problem down and we haven't been able to meaningfully describe and train LLMs to solve those kinds of problems in one unified model?
Well the fact that you can get an ensemble of Gemini models to act as an agent that make novel scientific discoveries, or improve methods like the measurement of aging - this is a fairly higher quality application of the idea of the automation of science with LLMs and LLM agents.
September 19, 2025 at 3:18 PM
Well the fact that you can get an ensemble of Gemini models to act as an agent that make novel scientific discoveries, or improve methods like the measurement of aging - this is a fairly higher quality application of the idea of the automation of science with LLMs and LLM agents.
Paper on the value of targeting aging before the ChatGPT era from the David Sinclair camp.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
The economic value of targeting aging - Nature Aging
An economic analysis suggests that targeting aging offers potentially larger economic gains than eradicating individual diseases. Slowing aging to increase life expectancy by 1 year is worth US$38 tri...
www.nature.com
September 19, 2025 at 3:13 PM
Paper on the value of targeting aging before the ChatGPT era from the David Sinclair camp.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Just a heads up these are aging clocks, not reducing human aging by 4.6 years - that would be worth... maybe $50 trillion US if Sinclair is right.
This aging clock has a lower Mean Absolute Error of 4.26 years.
But it's still an incredible application of agentic LLMs to aging and sci discovery.
This aging clock has a lower Mean Absolute Error of 4.26 years.
But it's still an incredible application of agentic LLMs to aging and sci discovery.
September 19, 2025 at 3:12 PM
Just a heads up these are aging clocks, not reducing human aging by 4.6 years - that would be worth... maybe $50 trillion US if Sinclair is right.
This aging clock has a lower Mean Absolute Error of 4.26 years.
But it's still an incredible application of agentic LLMs to aging and sci discovery.
This aging clock has a lower Mean Absolute Error of 4.26 years.
But it's still an incredible application of agentic LLMs to aging and sci discovery.
I don't want to go out there and kill them all but if they all died I'm not sure I'd miss them - though I might feel bad about it and wonder. It's hard to say.
September 19, 2025 at 5:17 AM
I don't want to go out there and kill them all but if they all died I'm not sure I'd miss them - though I might feel bad about it and wonder. It's hard to say.
Jeez I don't have time for all those words, heck I'm already 10 minutes late!!
September 19, 2025 at 4:59 AM
Jeez I don't have time for all those words, heck I'm already 10 minutes late!!
Because if a person where to get hit with a whip, it would smart.
a young boy is laying on a couch and making a funny face
ALT: a young boy is laying on a couch and making a funny face
media.tenor.com
September 19, 2025 at 4:58 AM
Because if a person where to get hit with a whip, it would smart.
Limitations / unaddressed questions
September 19, 2025 at 4:44 AM
Limitations / unaddressed questions