Base by Base
@basebybase.bsky.social
Base by Base is a podcast that explores the latest advances in genetics and genomics. Each episode breaks down key studies and their clinical relevance — one base at a time.
🎧 AAV delivery of MCT2 to the RPE increases lactate uptake and prolongs cone survival and function across RP models — listen for the mechanisms and FLIM data https://basebybase.com/?episode=274-rpe-specific-mct2-gene-delivery-preserves-cones-and-visi-1vgo8ej
January 29, 2026 at 9:25 AM
🎧 AAV delivery of MCT2 to the RPE increases lactate uptake and prolongs cone survival and function across RP models — listen for the mechanisms and FLIM data https://basebybase.com/?episode=274-rpe-specific-mct2-gene-delivery-preserves-cones-and-visi-1vgo8ej
🎧 New episode: CTVT-A captured a 15-Mb dicentric nuclear fragment (N-HT1) from a donor dog ~2,000 years ago; N-HT1 is transcriptionally active but appears selectively neutral https://basebybase.com/?episode=273-ctvt-a-acquires-15-mb-n-ht1-dicentric-nuclear-element-vi-23fpie
January 28, 2026 at 9:45 AM
🎧 New episode: CTVT-A captured a 15-Mb dicentric nuclear fragment (N-HT1) from a donor dog ~2,000 years ago; N-HT1 is transcriptionally active but appears selectively neutral https://basebybase.com/?episode=273-ctvt-a-acquires-15-mb-n-ht1-dicentric-nuclear-element-vi-23fpie
🎧 New PaperCast: Modern-human ADSL changes (A429V and regulatory haplotype) reduced enzyme activity, raised purine substrates in brain and altered female mouse water-seeking behav… https://basebybase.com/?episode=272-adsl-a429v-reduces-purine-biosynthesis-in-brain-and-alte-hm3a9a
January 27, 2026 at 8:59 AM
🎧 New PaperCast: Modern-human ADSL changes (A429V and regulatory haplotype) reduced enzyme activity, raised purine substrates in brain and altered female mouse water-seeking behav… https://basebybase.com/?episode=272-adsl-a429v-reduces-purine-biosynthesis-in-brain-and-alte-hm3a9a
🎧 New episode: EA PGI associations with years of education rose across UK birth cohorts 1946–1970 and were amplified in advantaged families — methods and implications discussed https://basebybase.com/?episode=271-rising-ea-pgi-prediction-of-educational-attainment-acros-1f9zw8k
January 26, 2026 at 2:41 AM
🎧 New episode: EA PGI associations with years of education rose across UK birth cohorts 1946–1970 and were amplified in advantaged families — methods and implications discussed https://basebybase.com/?episode=271-rising-ea-pgi-prediction-of-educational-attainment-acros-1f9zw8k
🎧 Single-molecule optical tweezers reveal human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negative DNA supercoils faster than PICH loop lifetimes, informing UFB res… https://basebybase.com/?episode=270-human-topoisomerase-iii-rmi1-rmi2-trr-processively-relax-1drah96
January 26, 2026 at 2:17 AM
🎧 Single-molecule optical tweezers reveal human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negative DNA supercoils faster than PICH loop lifetimes, informing UFB res… https://basebybase.com/?episode=270-human-topoisomerase-iii-rmi1-rmi2-trr-processively-relax-1drah96
🎧 New PaperCast episode: Mlh1–Pms1 directly makes strand-specific single-strand gaps to excise mismatches in reconstituted S. cerevisiae MMR https://basebybase.com/?episode=269-mlh1-pms1-endonuclease-creates-single-strand-gaps-to-exc-1bebnh
January 24, 2026 at 9:23 AM
🎧 New PaperCast episode: Mlh1–Pms1 directly makes strand-specific single-strand gaps to excise mismatches in reconstituted S. cerevisiae MMR https://basebybase.com/?episode=269-mlh1-pms1-endonuclease-creates-single-strand-gaps-to-exc-1bebnh
🎧 New PaperCast: β-cardiac myosin M493I disrupts the super-relaxed state, slows ADP release, and increases actin attachment and force—linking SRX loss to HCM hypercontractility https://basebybase.com/?episode=268-m493i-in-human-cardiac-myosin-srx-disruption-slow-adp-re-17pvu82
January 23, 2026 at 9:32 AM
🎧 New PaperCast: β-cardiac myosin M493I disrupts the super-relaxed state, slows ADP release, and increases actin attachment and force—linking SRX loss to HCM hypercontractility https://basebybase.com/?episode=268-m493i-in-human-cardiac-myosin-srx-disruption-slow-adp-re-17pvu82
🎧 New PaperCast Base by Base: Englander shows H-T and NMR H-H exchange reveal two DNA base-pair opening modes — single-base microsecond events and multi-base ms soliton-like loops https://basebybase.com/?episode=267-dna-base-pair-opening-modes-and-soliton-like-loops-revea-1gnueqx
January 22, 2026 at 9:00 AM
🎧 New PaperCast Base by Base: Englander shows H-T and NMR H-H exchange reveal two DNA base-pair opening modes — single-base microsecond events and multi-base ms soliton-like loops https://basebybase.com/?episode=267-dna-base-pair-opening-modes-and-soliton-like-loops-revea-1gnueqx
🎧 PaperCast Base by Base: TOP1α and TOP3β are upregulated in HPV31-positive keratinocytes and are differentially required for viral replication through distinct effects on R-loops… https://basebybase.com/?episode=266-top1-and-top3-differentially-regulate-hpv31-replication--utfwox
January 21, 2026 at 10:01 AM
🎧 PaperCast Base by Base: TOP1α and TOP3β are upregulated in HPV31-positive keratinocytes and are differentially required for viral replication through distinct effects on R-loops… https://basebybase.com/?episode=266-top1-and-top3-differentially-regulate-hpv31-replication--utfwox
🎧 New episode: How the lncRNA ANTSR acts as a conserved multiallelic sex-determining locus across Aculeata (ants, bees, wasps), functioning via heterozygosity despite no sequence… https://basebybase.com/?episode=265-antsr-lncrna-and-the-conserved-multiallelic-sex-determin-keh0qq
January 20, 2026 at 9:16 AM
🎧 New episode: How the lncRNA ANTSR acts as a conserved multiallelic sex-determining locus across Aculeata (ants, bees, wasps), functioning via heterozygosity despite no sequence… https://basebybase.com/?episode=265-antsr-lncrna-and-the-conserved-multiallelic-sex-determin-keh0qq
🎧 New Base by Base episode is live: Episode 264 — Single-TF rejuvenation: EZH2, E2F3, STAT3, ZFX identified by TRDP/Perturb-seq rejuvenate human fibroblasts and mouse liver • The study used passaged… basebybase.com?episode=264-...
January 19, 2026 at 9:20 AM
🎧 New Base by Base episode is live: Episode 264 — Single-TF rejuvenation: EZH2, E2F3, STAT3, ZFX identified by TRDP/Perturb-seq rejuvenate human fibroblasts and mouse liver • The study used passaged… basebybase.com?episode=264-...
🎧 New Base by Base episode is live — γPNA Janus-base triplets selectively bind expanded rCUG repeats, displace MBNL1, and partially rescue splicing in DM1 myotubes — listen basebybase.com?episode=263-...
January 19, 2026 at 1:48 AM
🎧 New Base by Base episode is live — γPNA Janus-base triplets selectively bind expanded rCUG repeats, displace MBNL1, and partially rescue splicing in DM1 myotubes — listen basebybase.com?episode=263-...
🎧 New Base by Base episode is live: Episode 262 — Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance) • The study uses clinical human… basebybase.com?episode=262-...
January 17, 2026 at 10:52 AM
🎧 New Base by Base episode is live: Episode 262 — Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance) • The study uses clinical human… basebybase.com?episode=262-...
🎧 New Base by Base episode is live: Episode 261 — MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping • The study probes crowded ferritin solutions using meg… basebybase.com?episode=261-...
January 17, 2026 at 10:51 AM
🎧 New Base by Base episode is live: Episode 261 — MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping • The study probes crowded ferritin solutions using meg… basebybase.com?episode=261-...
🎧 New Base by Base episode is live: Episode 260 — TSS hypermutability in human germline linked to RNAP II stalling, R-loops and early embryonic mosaics • The authors analysed extr… basebybase.com?episode=260-...
January 17, 2026 at 10:51 AM
🎧 New Base by Base episode is live: Episode 260 — TSS hypermutability in human germline linked to RNAP II stalling, R-loops and early embryonic mosaics • The authors analysed extr… basebybase.com?episode=260-...
Ku-Mtb forms extended filaments that hold DNA ends ~40 Å apart and the L13A/V14A mutation abolishes filament formation and reduces survival after MMS and desiccation basebybase.com?episode=259-...
January 14, 2026 at 9:22 AM
Ku-Mtb forms extended filaments that hold DNA ends ~40 Å apart and the L13A/V14A mutation abolishes filament formation and reduces survival after MMS and desiccation basebybase.com?episode=259-...
🎧 New Base by Base episode is live: Episode 258 — Correcting GC bias in metagenomes • GuaCAMOLE combines Kraken2/Bracken read assignment with per-taxon GC binning and a regularized least-squares estimator to infer GC-dependent s… basebybase.com?episode=258-...
January 14, 2026 at 12:44 AM
🎧 New Base by Base episode is live: Episode 258 — Correcting GC bias in metagenomes • GuaCAMOLE combines Kraken2/Bracken read assignment with per-taxon GC binning and a regularized least-squares estimator to infer GC-dependent s… basebybase.com?episode=258-...
🎧 New Base by Base episode is live: Episode 257 — PSMC5: proteasomes, immunity and neurodevelopment • Twenty-six distinct PSMC5 variants were identified in 44 affected individuals, mostly heterozygous and d… basebybase.com?episode=257-...
January 12, 2026 at 9:47 AM
🎧 New Base by Base episode is live: Episode 257 — PSMC5: proteasomes, immunity and neurodevelopment • Twenty-six distinct PSMC5 variants were identified in 44 affected individuals, mostly heterozygous and d… basebybase.com?episode=257-...