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basvansteensellab.bsky.social
Bas van Steensel lab (NKI)
@basvansteensellab.bsky.social
280 followers 31 following 5 posts
We are a research lab at the Netherlands Cancer Institute. We develop and apply new genomics tools to study genome biology and gene regulation.
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basvansteensellab.bsky.social
Bas van Steensel lab (NKI) @basvansteensellab.bsky.social · 14d
Our reporter hopping scaled up to thousands of integrations in a single locus, to produce high-resolution functional maps, with plenty of interesting insights: www.science.org/doi/10.1126/...
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene
Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...
www.science.org
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basvansteensellab.bsky.social
Bas van Steensel lab (NKI) @basvansteensellab.bsky.social · Sep 2
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
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basvansteensellab.bsky.social
Bas van Steensel lab (NKI) @basvansteensellab.bsky.social · May 17
Together with the De Ridder lab www.deridderlab.nl we just published a review on deep learning as a tool for gene expression analysis/ prediction: rdcu.be/elQCc.
Predicting gene expression from DNA sequence using deep learning models
Nature Reviews Genetics - Barbadilla-Martínez et al. review recent progress in deep-learning-based sequence-to-expression models, which predict gene expression levels solely from DNA sequence....
rdcu.be
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basvansteensellab.bsky.social
Bas van Steensel lab (NKI) @basvansteensellab.bsky.social · Mar 31
In @elife.bsky.social: Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function doi.org/10.7554/eLif...
Beyond A and B Compartments: how major nuclear locales define nuclear genome organization and function
doi.org
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basvansteensellab.bsky.social
Bas van Steensel lab (NKI) @basvansteensellab.bsky.social · Jan 13
Welcome to our lab! We are no longer active on Twitter/X. New results/preprints/papers will be posted here.
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