Bryan Quach
@bcquach.bsky.social
Bioinformatics engineer and scientist. Anything and everything related to improving DevX & SciX/ResX peaks my interest
Reposted by Bryan Quach
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing - Nature Genetics
This isoform-centric microglia genomic atlas includes 35,879 novel human microglia isoforms identified by long-read RNA sequencing. A multi-ancestry quantitative trait locus meta-analysis of known and...
www.nature.com
March 4, 2025 at 1:31 AM
Nice to see this finally published!
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Congratulations @jack-humphrey.bsky.social
www.nature.com/articles/s41...
(Collaborative work with Panos Roussos and his team! )
Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing
Recent @biorxivpreprint.bsky.social preprint showing that HIV-1 viral rebound populations in women with HIV (N=10) were predominantly established around time of ART initiation
doi.org/10.1101/2025.01.29.635391
doi.org/10.1101/2025.01.29.635391
HIV-1 Rebound Virus Consists of a Small Number of Lineages That Entered the Reservoir Close to ART Initiation
HIV-1 persists as a latent reservoir during suppressive antiretroviral therapy (ART). Viral rebound occurs upon ART interruption, posing a challenge to cure efforts. Characterizing viral populations f...
doi.org
February 6, 2025 at 5:29 PM
Recent @biorxivpreprint.bsky.social preprint showing that HIV-1 viral rebound populations in women with HIV (N=10) were predominantly established around time of ART initiation
doi.org/10.1101/2025.01.29.635391
doi.org/10.1101/2025.01.29.635391
Reposted by Bryan Quach
Great and important review! Differences between Seurat and Scanpy have always been sort of a black box to me...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
The impact of package selection and versioning on single-cell RNA-seq analysis
Standard single-cell RNA-sequencing analysis (scRNA-seq) workflows consist of converting raw read data into cell-gene count matrices through sequence alignment, followed by analyses including filterin...
www.biorxiv.org
December 16, 2024 at 9:06 PM
Great and important review! Differences between Seurat and Scanpy have always been sort of a black box to me...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Bryan Quach
Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Multiscale footprints reveal the organization of cis-regulatory elements - Nature
We developed PRINT, a computational method that identifies footprints of DNA–protein interactions from bulk and single-cell chromatin accessibility data across multiple scales of protein size.
www.nature.com
January 23, 2025 at 2:11 AM
Super excited to share our new study from the @jbuenrostro.bsky.social Lab in @nature.com! We developed a computational method for tracking transcription factor and nucleosome binding using single-cell ATAC-seq and deep learning.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...