JorgeBenitez
@benitezja.bsky.social
55 followers
100 following
63 posts
Passionate about #Science #Oncology #DrugDiscovery #protacs #ProteinDregradation #Neuroscience #cancer #organoids #pdx #epigenetics #omics
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Reposted by JorgeBenitez
JorgeBenitez
@benitezja.bsky.social
· Sep 3
Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer
The BRAF inhibitor encorafenib and anti-epidermal growth factor receptor (EGFR) antibody cetuximab modestly improve survival for patients with microsa…
www.sciencedirect.com
JorgeBenitez
@benitezja.bsky.social
· Aug 27
Load and lock: An emerging class of therapeutics that influence macromolecular dissociation
Biology is governed by macromolecular interactions, perturbation of which often lies at the heart of disease. Most therapeutic drugs, whether they are small molecules or biologics, exert their effects...
www.science.org
JorgeBenitez
@benitezja.bsky.social
· Aug 26
Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation
Glutarimide analogs, such as thalidomide, redirect the E3 ubiquitin ligase CRL4CRBN to induce degradation of certain zinc finger (ZF) proteins. Althou…
www.sciencedirect.com
JorgeBenitez
@benitezja.bsky.social
· Aug 12
Discovery of BMS-986365, a first-in-class dual androgen receptor ligand-directed degrader (AR LDD) and antagonist, for the treatment of advanced prostate cancer
Abstract. Purpose: BMS-986365, a heterobifunctional AR LDD, was designed as a potent cereblon-dependent degrader and competitive antagonist of AR to overcome resistance to ARPIs in metastatic prostate...
aacrjournals.org
JorgeBenitez
@benitezja.bsky.social
· Aug 5
T-cell Dependency of Tumor Regressions and Complete Responses with RAS(ON) Multi-selective Inhibition in Preclinical Models of Pancreatic Ductal Adenocarcinoma
Broad-spectrum RAS inhibition acts in concert with the immune system to achieve deep antitumor responses.
aacrjournals.org
JorgeBenitez
@benitezja.bsky.social
· Jul 25
Unveiling the hidden interactome of CRBN molecular glues - Nature Communications
Induced proximity by molecular glues is a strategy that leverages the recruitment of proteins to facilitate their modification or degradation. Here the authors present unbiased quantitative proteomic,...
www.nature.com
JorgeBenitez
@benitezja.bsky.social
· Jul 23
Response and Resistance to RAS Inhibition in Cancer
AbstractRAS inhibition has the potential to transform cancer treatment for many patients. The landscape of RAS inhibitor therapies is rapidly evolving, with two mutant-selective KRAS inhibitors now ap...
aacrjournals.org
JorgeBenitez
@benitezja.bsky.social
· Jul 15
Response and Resistance to RAS Inhibition in Cancer
AbstractRAS inhibition has the potential to transform cancer treatment for many patients. The landscape of RAS inhibitor therapies is rapidly evolving, with two mutant-selective KRAS inhibitors now ap...
aacrjournals.org
JorgeBenitez
@benitezja.bsky.social
· Jul 8
An unexpected career in cancer metabolism - Nature Cancer
Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Genetics at Children’s Hospital of Philadelphia. He moved to the University of Tex...
www.nature.com