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Reposted by Benjamin Werner

Inigo Martincorena @imartincorena.bsky.social · 9h

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Somatic mutation and selection at population scale - Nature

A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

www.nature.com

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Benjamin Werner @benjaminwerner.bsky.social · 16h

Hope they switch off the water sprinklers by then

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Reposted by Benjamin Werner

Elizabeth McKenna @elizsmckenna.bsky.social · 2d

The October issue of Cancer Discovery @aacrjournals.bsky.social is now online! The cover features two papers on the role of #ecDNA heterogeneity in tumor evolution and adaptation to therapy - you can find these papers and much more here: aacrjournals.org/cancerdiscov...

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Benjamin Werner @benjaminwerner.bsky.social · 2d

In the hope the academic system has and continues to improve since.

Elizabeth Wood, PhD @lizbwood.bsky.social · 2d

For every Nobel that goes to a criminally under-recognized woman scientist (Brunkow, Karikó), or fails to go (Candy Lee), a week of mourning and reform for an academic system wherein you can do Nobel-prize-worthy-work and still end up without a conceivable path to being a professor.

Nature @nature.com · 2d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

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Benjamin Werner @benjaminwerner.bsky.social · 2d

See also the spotlight article for a great summary

aacrjournals.org/cancerdiscov...

Extrachromosomal DNA: A Trusted Path to Tumor Heterogeneity

Summary:. Extrachromosomal DNA (ecDNA) has been suggested as a key factor of tumor heterogeneity at the genomic and transcriptional levels, via unequal segregation and ecDNA hub formation, respectivel...

aacrjournals.org

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Benjamin Werner @benjaminwerner.bsky.social · 2d

Very happy ecDNA has made the cover at @aacrjournals.bsky.social, highlighting two articles in the current issue, one on MYC(N) amplification in Neuroblastoma and one on the spatial heterogeneity of ecDNA amplified oncogenes in GBM.

aacrjournals.org/cancerdiscov...

Volume 15 Issue 10 | Cancer Discovery | American Association for Cancer Research

aacrjournals.org

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Reposted by Benjamin Werner

Nature @nature.com · 2d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

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Benjamin Werner @benjaminwerner.bsky.social · 3d

I am so out of fashion that I never heard about Bad Bunny before, but your argument seems sound.

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Reposted by Benjamin Werner

Wolfgang Huber @wkhuber.bsky.social · 9d

Do you like theoretical biology, mathematical&conceptual modelling and want to apply yourself to cutting-edge research at all levels of biology, from molecules to ecosystems?

Come to EMBL! Scope includes physics-based models, emergence, statistics, ML/AI
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

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Benjamin Werner @benjaminwerner.bsky.social · 12d

You can follow sections on BioRxiv you are interested in. Every week there is quite a lot of interesting work posted there.

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Reposted by Benjamin Werner

Joshua Weitz @joshuasweitz.bsky.social · 15d

Both in the near- and long-term:

"Medicine and science will, if funded, find answers for autism, heart disease, cancer, birth defects, mental illness, and diabetes. Presidents, lawyers, and bureaucratic toadies will not."

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Reposted by Benjamin Werner

Sandy Anderson @sandyanderson.bsky.social · 14d

Excited to announce that registration for the 13th
@mathonco.bsky.social workshop on Treatment Revolution is now open. Held onsite @moffittnews.bsky.social Nov 2-Nov 7 #MoffittIMO more details: imo13.eventbrite.com. Deluxe travel awards are available on a competitive basis, apply by 10/03!

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Reposted by Benjamin Werner

Sandy Anderson @sandyanderson.bsky.social · 14d

If you are interested in learning more about what an IMO Workshop is like check out our dedicated website: imoworkshop.org. Note the workshop this year runs directly after our #MathOnco25 meeting: mathematical-oncology.org/mathonco25.

#MoffittIMO Workshop

imoworkshop.org

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Benjamin Werner @benjaminwerner.bsky.social · 16d

For even the very wise cannot see all ends.

Benjamin Werner @benjaminwerner.bsky.social · 16d

But who reviews the reviewers?

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Benjamin Werner @benjaminwerner.bsky.social · 16d

or do not understand, or do not have moral or all.

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Benjamin Werner @benjaminwerner.bsky.social · 16d

Read Hannah Arendt.

It’s all there, it’s all known and yet we fall for the same cheap demagogy time and again.

What does this say about humankind?

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Benjamin Werner @benjaminwerner.bsky.social · 16d

Force always attracts man of low morality.

A.E.

Benjamin Werner @benjaminwerner.bsky.social · 19d

The IG noble in physics goes to Italy to discover the physics of pasta sauce.

Amazing.

I am sure that was a main scientific priority of the government supported by billions of euros 😂

Joseph Luna @virologistjoe.bsky.social · 19d

Lol, I guess I called this one a few weeks in advance. They just won for physics!

arstechnica.com/science/2025...

Meet the 2025 Ig Nobel Prize winners

The annual award ceremony features miniature operas, scientific demos, and the 24/7 lectures.

arstechnica.com

Benjamin Werner @benjaminwerner.bsky.social · 19d

“I think if it was possible, AI labs would have done it already.”

… Well …

www.nature.com/articles/d41...

Can researchers stop AI making up citations?

OpenAI’s GPT-5 hallucinates less than previous models do, but cutting hallucination completely might prove impossible.

www.nature.com

Benjamin Werner @benjaminwerner.bsky.social · 20d

And I am asking again. Where are the protests in the United States?

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Reposted by Benjamin Werner

Sofya Garushyants @garushyants.bsky.social · 23d

hey bluesky 👋 visa hurdles mean I’m looking for opportunities outside the US. I’m a computational biologist (bacterial + phage genomics, postdoc in Koonin’s group @ NIH). I am interested in teaming up on funding apps. reach out if this resonates!

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Benjamin Werner @benjaminwerner.bsky.social · 26d

To cite the great Steven Weinberg:

"A society that only funds applied over basic research will end up with neither."

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Benjamin Werner @benjaminwerner.bsky.social · 26d

The problem lies in how one defines and determines low quality research.

Science funding is and in our current society always will be competitive, so society has to make decisions what to fund.

To only focus on short term applied research with seemingly immediate impact is stupid though.

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Reposted by Benjamin Werner

Trevor Graham @trevorgraham.bsky.social · 28d

Studying cancer evolution needs multi-region or single cell seq for phylogenetics, right? Amazingly (I think!) we found single-sample bulk methylation suffices, via analysis of "fluctuating methylation". In @nature.com today led by brilliant @calumgabbutt.bsky.social www.nature.com/articles/s41...

Fluctuating DNA methylation tracks cancer evolution at clinical scale - Nature

Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

www.nature.com

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