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bennyscience.bsky.social
Richard Benninger
@bennyscience.bsky.social
200 followers 160 following 10 posts
Bioengineering to cure diabetes. Father of 2. Ski and hike in remaining time. Colorado. 🇺🇦 Benningerlab.com
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Richard Benninger @bennyscience.bsky.social · 22d
Great work Mark, Mohammad and co. Nice to see this out- congratulations!
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bennyscience.bsky.social
Richard Benninger @bennyscience.bsky.social · Jul 21
Nice work Scott!
soleimanpourlab.bsky.social
Scott Soleimanpour @soleimanpourlab.bsky.social · Jul 21
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔

🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n
LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism
LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...
nature.com
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bennyscience.bsky.social
Richard Benninger @bennyscience.bsky.social · Apr 29
Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!

www.biorxiv.org/content/10.1...
Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.
While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...
www.biorxiv.org
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bennyscience.bsky.social
Richard Benninger @bennyscience.bsky.social · Apr 21
For sure- all the feasible alternatives keep dropping!
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bennyscience.bsky.social
Richard Benninger @bennyscience.bsky.social · Feb 8
Apparently NIH is seeking to impose a standard 15% indirect cost rate going forward. That will be disruptive to say the least:
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
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bennyscience.bsky.social
Richard Benninger @bennyscience.bsky.social · Jan 29
Check out our ‘Paper of the Month’, led by Anne Gresch. Also coming to a Diabetes podcast soon!
diabetesjournals.org/diabetes/art...
Resolving spatiotemporal electrical signaling within the islet via CMOS microelectrode arrays
Glucose-stimulated beta-cells exhibit synchronized calcium dynamics across the islet that recruit beta-cells to enhance insulin secretion. Compared to calc
diabetesjournals.org
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bennyscience.bsky.social
Richard Benninger @bennyscience.bsky.social · Nov 14
Mainly type1 diabetes, but there are a few things relevant type2 as well. But lots of exciting things going on in type1 research at the moment!
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bennyscience.bsky.social
Richard Benninger @bennyscience.bsky.social · Nov 13
Particularly passionate about Colorado, islet biology and microscopy!
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bennyscience.bsky.social
Richard Benninger @bennyscience.bsky.social · Nov 13
Hello everyone- I work in diabetes research and will post about our research, but also like to follow and comment on English football (soccer) and American football (football).
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Richard Benninger @bennyscience.bsky.social · Nov 13
Do you miss writing about finance and the railways?