Ben Weger
@benweger.bsky.social
Huge thanks to everybody involved including @fgachon.bsky.social @melweger.bsky.social @robparton.bsky.social @benschulz.bsky.social @danielmauvoisin.bsky.social but many more (i.e., those not on Bluesky)!
February 5, 2026 at 10:00 AM
Huge thanks to everybody involved including @fgachon.bsky.social @melweger.bsky.social @robparton.bsky.social @benschulz.bsky.social @danielmauvoisin.bsky.social but many more (i.e., those not on Bluesky)!
9/9 Altogether, our work adds a new layer to how glycogen metabolism times liver function, with implications for metabolic disease.
February 5, 2026 at 10:00 AM
9/9 Altogether, our work adds a new layer to how glycogen metabolism times liver function, with implications for metabolic disease.
8/9 Why might this be important? In obesity, circulating protein and ER stress rhythms are flattened. Furthermore, genetic variants in glycogen metabolism and glycosylation genes correlate with altered blood protein levels in humans.
February 5, 2026 at 10:00 AM
8/9 Why might this be important? In obesity, circulating protein and ER stress rhythms are flattened. Furthermore, genetic variants in glycogen metabolism and glycosylation genes correlate with altered blood protein levels in humans.
7/9 To test causality, we blocked liver glycogen breakdown using CP-91149. Inhibiting glycogenolysis reduced protein glycosylation, triggered ER stress, and reduced protein secretion.
February 5, 2026 at 10:00 AM
7/9 To test causality, we blocked liver glycogen breakdown using CP-91149. Inhibiting glycogenolysis reduced protein glycosylation, triggered ER stress, and reduced protein secretion.
6/9 What drives this rhythm? Glycogen. It’s one of the most rhythmic liver metabolites. Glycogenolysis converts it into highly rhythmic UDP-sugars, which serve as substrates for protein N-glycosylation. 🍬
February 5, 2026 at 10:00 AM
6/9 What drives this rhythm? Glycogen. It’s one of the most rhythmic liver metabolites. Glycogenolysis converts it into highly rhythmic UDP-sugars, which serve as substrates for protein N-glycosylation. 🍬
5/9 These observations are supported by the liver's ultrastructure. We found striking temporal dynamics: ER volume peaks during the day in the liver, while the Golgi apparatus is almost exclusively detectable at night. 🔬
February 5, 2026 at 10:00 AM
5/9 These observations are supported by the liver's ultrastructure. We found striking temporal dynamics: ER volume peaks during the day in the liver, while the Golgi apparatus is almost exclusively detectable at night. 🔬
4/9 Using microsomal proteomics, we found the liver's early secretory pathway (ER and Golgi) is temporally compartmentalised. ER-resident chaperones and Golgi matrix proteins peak at different times, coinciding with daily waves of protein N-glycosylation.
February 5, 2026 at 10:00 AM
4/9 Using microsomal proteomics, we found the liver's early secretory pathway (ER and Golgi) is temporally compartmentalised. ER-resident chaperones and Golgi matrix proteins peak at different times, coinciding with daily waves of protein N-glycosylation.
3/9 Strikingly, these rhythms disappear when calories are spread evenly across the day (hourly sipping a nutritionally balanced solution). This raised a key question: are blood protein rhythms driven by rhythmic secretion from the liver itself?
February 5, 2026 at 10:00 AM
3/9 Strikingly, these rhythms disappear when calories are spread evenly across the day (hourly sipping a nutritionally balanced solution). This raised a key question: are blood protein rhythms driven by rhythmic secretion from the liver itself?
2/9 The liver has many jobs, including making key blood proteins. We used to think this happened continuously, but our work shows that many circulating proteins follow clear daily rhythms.
February 5, 2026 at 10:00 AM
2/9 The liver has many jobs, including making key blood proteins. We used to think this happened continuously, but our work shows that many circulating proteins follow clear daily rhythms.
Fremantle Chamber chief Chrissie Maus says DST forces teams to adapt - starting earlier, shifting schedules, and tweaking operations just to stay in sync. - This real concern shows why ditching DST is the simple fix we need. Here’s why rebrand.ly/o4sa8np.
Daylight saving time ends Sunday. Why do we change our clocks? And how does it affect our bodies?
Here’s how your body might respond when you turn your clock back an hour on Saturday night.
rebrand.ly
April 5, 2025 at 3:51 AM
Fremantle Chamber chief Chrissie Maus says DST forces teams to adapt - starting earlier, shifting schedules, and tweaking operations just to stay in sync. - This real concern shows why ditching DST is the simple fix we need. Here’s why rebrand.ly/o4sa8np.