bernard-s-lopez.bsky.social
@Bernard-S-Lopez.bsky.social
@bernard-s-lopez.bsky.social
51 followers 65 following 3 posts
Research Director at CNRS. Cochin Institute. Genome Stability instability, DNA repair and recombination, replication stress. Nanomaterials, Clay mineral, silicates
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bernard-s-lopez.bsky.social
@Bernard-S-Lopez.bsky.social @bernard-s-lopez.bsky.social · 14d
Plot twist: homologous recombination actually promotes the development of cancer!

This discussion has been started in the hope that it will be useful, see the link:

doi.org/10.1038/s413...
RAD51-mediated homologous recombination is a pro-tumour driver pathway - Oncogene
Oncogene - RAD51-mediated homologous recombination is a pro-tumour driver pathway
doi.org
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bernard-s-lopez.bsky.social
@Bernard-S-Lopez.bsky.social @bernard-s-lopez.bsky.social · Jun 20
The LoL-DDR (doi.org/10.1038/s414...)
is dysregulated in transformed cell lines (doi.org/10.1038/s415...)
A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner - Cell Death & Differentiation
Cell Death & Differentiation - A noncanonical response to replication stress protects genome stability through ROS production, in an adaptive manner
doi.org
1
bernard-s-lopez.bsky.social
@Bernard-S-Lopez.bsky.social @bernard-s-lopez.bsky.social · Jun 11
The hyper-activation of DNA double-strand break repair by the AKT1/PKB oncogene generates genetic instability.
(A new role for the oncogene AKT1: the phosphorylation of MRE11).
academic.oup.com/nar/article-...
Genome rearrangements induced by the stimulation of end-joining of DNA double strand breaks through multiple phosphorylation of MRE11 by the kinase PKB/AKT1
Abstract. Genetic instability is a major hazard threatening the fate of cells and ultimately of organisms. DNA double-strand break (DSB) is a highly toxic
academic.oup.com
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Reposted by @Bernard-S-Lopez.bsky.social
rosenberglabbcm.bsky.social
RosenbergLabBCM @rosenberglabbcm.bsky.social · Feb 21
What RNA polymerase gets up to in the genome and how mutations happen! Just out in Nature! Many thanks to many collaborators & congrats 1st author Jingjing Liu! www.nature.com/articles/s41...
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