Hanks Lab further verifies the critical role of the tumor NLRP3 signaling pathway in cancer immunotherapy resistance in their recent preprint, 'Tumor NLRP3 Amplification Promotes Immunotherapy Resistance by Suppressing MHC Class I Expression'. medRxiv. doi: 10.1101/2025.10.0625337175. PMID: 41292902

Hanks Lab presents at #SITC2025, Abstract #766: 'mregDCs Propagate Tumor Immune Tolerance by Suppressing Conventional DC-dependent Activation of CD8+ T Cells via Paracrine PCSK9 Signaling'
unclineberger.org/hankslab/

Hanks Lab continues their exploration of tumor-intrinsic pathways of immunotherapy resistance in May 1 issue of Cancer Research: Role of Gli2 in coordinating immune evasion via the Wnt and PGE2 signaling pathways. DOI: 10.1158/0008-5472.CAN-24-1130.
@bhanksmdphd.bsky.social‬

Hanks Lab presents updated data on their investigation of tumor-mediated dendritic cell tolerization in the TME at #AACR25: Abstract #916:
'Tumor extracellular vesicles trigger a dendritic cell stress response to promote immune evasion and immunotherapy resistance'
@unclineberger.bsky.social