Billy Ng
@billy-ng.bsky.social
Asso. Prof @CUHK. Trained in Harvard / Oxford / MIT / CUHK. World Economic Forum YGL. Recruiting chemical biologists to join my lab!
Pinned
Billy Ng
@billy-ng.bsky.social
· Jul 20
[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/10.1021/...
Excited to share our 2nd-gen OGTAC🎯: we turned a potent inhibitor into a non-inhibitory covalent binder, enabling targeted O-GlcNAcylation🍬Congrats to the OGTAC team @CUHK, esp. PhD student Zhihao! also thanks to collaborators at Kyoto Univ. & HKU! Link: pubs.acs.org/doi/10.1021/...
Ligand-Directed Self-Assembling Chimeras for Targeted Protein O-GlcNAcylation
Precise control of protein-specific O-GlcNAcylation in cells remains a major challenge. Chemically induced proximity (CIP) offers a promising path forward, but its application to targeted protein O-Gl...
pubs.acs.org
December 20, 2025 at 3:50 PM
Excited to share our 2nd-gen OGTAC🎯: we turned a potent inhibitor into a non-inhibitory covalent binder, enabling targeted O-GlcNAcylation🍬Congrats to the OGTAC team @CUHK, esp. PhD student Zhihao! also thanks to collaborators at Kyoto Univ. & HKU! Link: pubs.acs.org/doi/10.1021/...
Reposted by Billy Ng
Activation and regulation of cGAS-STING signaling in cancer cells
Activation and regulation of cGAS-STING signaling in cancer cells
Cancer-intrinsic genomic instability drives cytosolic DNA accumulation, triggering cGAS-STING immune signaling. Shim et al. review recent advances in cancer/cGAS-STING crosstalk, with a molecular-level focus on sources of cytosolic DNA and immunoregulatory mechanisms, including their therapeutic implications.
dlvr.it
October 17, 2025 at 10:58 PM
Activation and regulation of cGAS-STING signaling in cancer cells
Great to present our work on chemically induced proximity for modulating glycosylation at the ACS Publications Symposium! 🧪⚗️Inspiring to share the stage with giants such as Profs. Carolyn Bertozzi and Chris Chang😃 Big thanks to Ng Lab @CUHK for driving this!
October 3, 2025 at 9:19 AM
Great to present our work on chemically induced proximity for modulating glycosylation at the ACS Publications Symposium! 🧪⚗️Inspiring to share the stage with giants such as Profs. Carolyn Bertozzi and Chris Chang😃 Big thanks to Ng Lab @CUHK for driving this!
I got tenure and promotion to Asso. Prof. at CUHK!😃Deeply grateful to my incredible team and collaborators for their dedication and support!💡If you're passionate about drugging the undruggable with chemical-induced proximity tools💊, reach out to us: ngwailung.com
August 3, 2025 at 4:15 AM
I got tenure and promotion to Asso. Prof. at CUHK!😃Deeply grateful to my incredible team and collaborators for their dedication and support!💡If you're passionate about drugging the undruggable with chemical-induced proximity tools💊, reach out to us: ngwailung.com
[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/10.1021/...
July 20, 2025 at 4:42 AM
[NEW paper!] Proximity-induced O-GlcNAcylation: we showed that a single sugar modification can act as a molecular switch that triggers protein degradation & more!🍬Huge congrats to the OGTAC team!👏Open-Access Article: pubs.acs.org/doi/10.1021/...