Michael Kuhn
@biocs.bsky.social
260 followers 170 following 38 posts
Computational biologist. Research staff scientist and research coordinator in the @borklab.bsky.social at @embl.org Heidelberg.
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Reposted by Michael Kuhn
biorxiv-microbiol.bsky.social
Metagenomics reveal allopatric speciation and higher connectivity among coastal vs. inland hypersaline lakes and solar salterns https://www.biorxiv.org/content/10.1101/2025.10.01.679725v1
Reposted by Michael Kuhn
oceanna.bsky.social
Had a great time yesterday presenting my efforts to use large-scale computational analyses to better understand marine microbes and their impact on carbon cycling. Thanks #SAME18 for the opportunity!
Reposted by Michael Kuhn
evolvedbiofilm.bsky.social
Cool PNAS paper by @jordivangestel.bsky.social and colleagues
Contributed by Carol Gross
[reviewed by @polzlab.bsky.social and @wcratcliff.bsky.social]

Bacillus subtilis in defense mode: Switch-like adaptations to protistan predation

www.pnas.org/doi/10.1073/...
Reposted by Michael Kuhn
wormsrock.bsky.social
C. elegans is a real animal and we set out to understand how it comes to have its distinctive biogeography. Its ancestral center of diversity is in the higher elevation forests of Hawaii. Its closest relatives are spread across east Asia. Did they travel from Asia? [Preprint 🧵]
Reposted by Michael Kuhn
pamferretti.bsky.social
If you generate or reuse #microbiome data, check out these guidelines for equitable sequence data reuse. Grateful to @alexjprobst.bsky.social and his team for leading this important work and for bringing together 160+ microbiome scientists (myself included) to contribute!

doi.org/10.1038/s415...
Reposted by Michael Kuhn
arnausebe.bsky.social
Happy to share the Biodiversity Cell Atlas white paper, out today in @nature.com. We look at the possibilities, challenges, and potential impacts of molecularly mapping cells across the tree of life.
www.nature.com/articles/s41...
Reposted by Michael Kuhn
Reposted by Michael Kuhn
friendlymicrobe.bsky.social
A colleague received proofs of an accepted manuscript, and the "proofing process" clearly involved running the text through ChatGPT. Their voice has been erased, and errors introduced. This is from a supposedly reputable publisher. Anyone else been put through this particular form of hell? #MicroSky
Reposted by Michael Kuhn
infect-net.bsky.social
🏆 Fighting the Gender Award Gap: Microbiologist Prof Dr Lisa Maier from @unituebingen.bsky.social received the main award of the German Association for #Microbiology and Hygiene at the #DGHM meeting in Jena. Congratulations to @lisamaierlab.bsky.social we are proud of you! 💜
📸 Gabriele Pradel
Bildschirmpräsentation mit der Vita von Prof. Dr. Lisa Maier, Mikrobiologin an der Uni Tübingen, zur Verleihung des Hauptpreises der DGHM in Jena. Mikrobiologin Prof. Dr. Antje Flieger liest die Laudatio für Prof. Dr. Lisa Maier zur Verleihung des Hauptpreises der DGHM in Jena. Preisträgerin Lisa Maier steht links neben ihr.
Reposted by Michael Kuhn
events.embl.org
Our scientific organisers opened ‘The human microbiome’ symposium by giving us a brief update on their most recent work 🦠 #EESMicrobiome

🔹Mani Arumugam, University of Copenhagen
🔹Ami Bhatt, Stanford University School of Medicine
🔹Peer Bork, EMBL Heidelberg
🔹Nicola Segata, University of Trento
biocs.bsky.social
Da ich in Leipzig aufgewachsen bin muss ich doch zur Ehrenrettung der Stadt schreiben, dass die tatsächlich einen Plan hat um die Wärmeversorgung zu Dekarbonisieren, u.a. eine neue Fernwärmeleitung nach Leuna um Abwärme zu nutzen

zukunft-fernwaerme.de
Leipziger Wärme
Leipzig hat beste Voraussetzungen, die kommunale Wärmewende erfolgreich zu gestalten. Dazu hat der Stadtrat den Auftrag erteilt, eine kommunale Wärmeplanung zu erstellen. Ziel der Stadt Leipzig ist es...
zukunft-fernwaerme.de
Reposted by Michael Kuhn
thomasp85.com
I am beyond excited to announce that ggplot2 4.0.0 has just landed on CRAN.

It's not every day we have a new major #ggplot2 release but it is a fitting 18 year birthday present for the package.

Get an overview of the release in this blog post and be on the lookout for more in-depth posts #rstats
ggplot2 4.0.0
A new major version of ggplot2 has been released on CRAN. Find out what is new here.
www.tidyverse.org
Reposted by Michael Kuhn
lpachter.bsky.social
In a new work with Joseph Rich and Conrad Oakes we tackle the problem of how to best organize alluvial plots. We formalize two optimization problems and develop a solution for them based on the neighbornet algorithm, implemented in the program wompwomp: github.com/pachterlab/w...
Reposted by Michael Kuhn
rayanchikhi.bsky.social
🌎👩‍🔬 For 15+ years biology has accumulated petabytes (million gigabytes) of🧬DNA sequencing data🧬 from the far reaches of our planet.🦠🍄🌵

Logan now democratizes efficient access to the world’s most comprehensive genetics dataset. Free and open.

doi.org/10.1101/2024...
Reposted by Michael Kuhn
patschloss.bsky.social
My google skills are failing... Back in 2011, NCBI (started to?) close the SRA. The SRA is still with us. Anyone know of any articles from around then about how they saw the light? For those that this is news to...

genomebiology.biomedcentral.com/articles/10....
Closure of the NCBI SRA and implications for the long-term future of genomics data storage - Genome Biology
genomebiology.biomedcentral.com
Reposted by Michael Kuhn
acritschristoph.bsky.social
Soo.... the last time it was online was April 1 2025 (consistently offline April 4 onwards)
web.archive.org/web/20250401...

My (limited) understanding is that hmpdacc.org is recently run by a team at IGS UMD, and the website being offline may or may not relate to changes at the NIH
Reposted by Michael Kuhn
brendelbored.bsky.social
This is in the replies and it demonstrates a real issue which is if you find profundity from an AI, you’re responding to something profound a human being wrote that was vacuumed up and what ends up happening is you thank AI and not only don’t thank the person, you have no idea they were involved
Michael Love@elkmovie.bsky.social • 6m
I thought this sounded familiar and it turns out it literally just found an old George RR
Martin quote and wrote a short story out of it:
George R.R. Martin > Quotes > Quotable Quote (?)
"I think there are two types of writers, the architects and the gardeners.
The architects plan everything ahead of time, like an architect building a house. They know how many rooms are going to be in the house, what kind of roof they're going to have, where the wires are going to run, what kind of plumbing there's going to be. They have the whole thing
designed and blueprinted out before they even nail the first board up. The gardeners dig a hole, drop in a seed and water it. They kind of know what seed it is, they know if planted a fantasy seed or mystery seed or whatever. But as the plant comes up and they water it, they don't know how many branches it's going to have, they find out as it grows. And I'm much more a gardener than an architect."
ALT
- George R.R. Martin
biocs.bsky.social
Going from an internal database to a public resource required a lot of work in the past year to enforce consistency, and I'm sure there are still some inconsistencies left. But such is life with >100k entries! 6/7
biocs.bsky.social
We have already made good use of part of the data in publications, e.g. doi.org/10.1136/gutj... doi.org/10.1038/s415... doi.org/10.7554/eLif... doi.org/10.1016/j.ce... doi.org/10.1101/2024... to study biomarkers for pancreatic cancer, associations with microbial load, or the spread of C. diff 5/7
Figure 3 from Kartal et al. 2022, showing that the proposed signature of pancreatic duct carcinoma mainly has a low false-positive rate for other diseases
biocs.bsky.social
The database grew from human data to animal and environmental data, and now covers the whole globe (and even the International Space Station). I'm still fascinated by the tracks of expeditions across the oceans and samples from Antarctica to Greenland 4/7
A map of the globe showing the distribution of samples in Metalog