Can genetic testing effectively identify clinically significant variants for schizophrenia?

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Want to learn more about the Adolescent Brain Cognitive Development study?👀 Check out the ABCD-ReproNim course! The Fall 2025 course is going on NOW✨ Students may have the opportunity to participate in the 2026 hackathon in Miami🏝️ For more info: abcd-repronim.org 🎉

In this narrative review of recent MRI studies, Gonçalves and colleagues found that while prenatal cannabis exposure is linked to brain differences from in utero to adolescence, diverse methodologies and confounding factors currently prevent a consistent understanding of its impact.

Using brain-based graph-theoretical predictive modeling, Schettino and colleagues identified specific properties within the default mode, frontoparietal, and limbic networks that accurately predict the severity, fluctuations, and clinical features of repetitive negative thinking in daily life.

Latest work from @brikchen.bsky.social @drchristineannd.bsky.social and others shows that combining ketamine and prucalopride is more effective than either drug alone at reducing stress-induced physiology at the neural and behavioral levels, suggesting a promising new treatment approach.

In this review, @lucinauddin.bsky.social and Hugh Garavan examine how task and resting-state fMRI can reveal brain-behavior relationships in youth, highlighting current controversies and challenges, outlining solutions, and proposing future directions in developmental neuroscience research.

Check out the entire issue here:

Commentary on Chowdhury et al. by Hossein

Chowdhury et al. analyzed data from a RCT to demonstrate that ezogabine, a potassium channel opener, reduced depression and anhedonia symptoms by decreasing connectivity between reward and the mid/posterior cingulate regions.

Commentary on Hannon et al. by Rosso

Hannon et al. found that depression subtypes with distinct clinical features show different brain imaging patterns, and some patients with identical presentations can have different neuroimaging profiles, revealing complex relationships between clinical and neurobiological heterogeneity.

Early Career Investigator Commentary on Nikkheslat et al. by Youn

Nikkheslat et al. identified that adolescent females at high risk for or with depression showed reduced neuroprotective kynurenine pathway metabolites, with increased neurotoxic metabolite production predicting persistent depression in females but not males.

Commentary on Pomrenze et al. by Zorumski and Mennerick

Pomrenze et al. demonstrate that ketamine-induced increases in locomotor activity depends on μ-opioid receptors in the central amygdala.

Reay et al. revew genetic relationships between cardiometabolic traits and anorexia nervosa, discussing how BMI-based diagnostic criteria complicate interpretation of these associations, and outline recommendations for future genetic research.

Cardona-Acosta et al. provide a comprehensive review of ketamine as a prophylactic treatment for stress-induced disorders, covering mechanisms of action, associated risks and limitations, and implications for future clinical practice.

Our latest issue, focused on Mechanisms of Depression and Antidepressant Pharmacotherapy, is now online!

This issue includes archival reports, reviews, and commentaries. ⬇️

The Biological Psychiatry family of journals is now officially on Bluesky!

Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.

The Biological Psychiatry family of journals is now officially on Bluesky!

Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.