By promoting mitophagy, PFD lessens oxidative stress, a major driver of fibrosis, by clearing dysfunctional mitochondria that produce reactive oxygen species.

I do hope that tirzepatide tamps down LC symptoms. Here is a report from one long-hauler, "I tried Tirzepatide a few wks ago and it intensified everything, pain, neuropathy , autonomic system. It was terrible!!!"

SGLT2 inhibitors (like dapagliflozin, empagliflozin) activate autophagy, the cell's cleanup process, by mimicking a fasting state, reducing energy surplus signals (mTOR), and boosting energy sensors (AMPK, SIRT1)

I am concerned that JAK-STAT inhibitors will enable viral replication and worsen LC trajectories.

The U09.9 code is general, (Post COVID-19 condition, unspecified) ; providers also use additional ICD-10-CM codes for specific symptoms (like fatigue, brain fog, heart issues) or underlying conditions that characterize the Long COVID presentation.

I agree Julia. However vaccines can stimulate immunity... potentially unmasking persistent viral infection. www.sciencedirect.com:5037/science/arti...

To learn more, here is a 40 min video about the trial. youtu.be/BP9s5hG9Fc8

I agree that periodic induction of autophagy may be beneficial for Long COVID. In our Intermittent Fasting trial, on average the top-half of participants saw an 81% decrease in their composite Long COVID severity scores and 70% of their symptoms went away completely. doi.org/10.1038/s415...

Pleased to share our positive #LongCOVID trial results. A patient-friendly, low burden, all remote trial. The top half of participants had a mean 80% decrease in their Long Covid symptom burden.

doi.org/10.1038/s415...

Pleased to share our positive #LongCOVID trial results. A patient-friendly, low burden, all remote trial. The top half of participants had a mean 80% decrease in their Long Covid symptom burden.

doi.org/10.1038/s415...

Pleased to share our positive #LongCOVID trial results. A patient-friendly, low burden, all remote trial. The top half of participants had a mean 80% decrease in their Long Covid symptom burden.

doi.org/10.1038/s415...

And perhaps SARS-CoV-2... Long COVID certainly feels like viral persistence.

This is BIG! It counters the viral inhibition of autophagosome-lysosomal fusion.
"SB431542 directly binds to SARS-CoV-2 ORF3a and disrupts its canonical function in inhibiting autophagosome-lysosome fusion. This interaction restored lysosomal acidification"

Mine is just a few days away from submission. Great to have lunch with you in Santa Fe!