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Baptiste Lacoste @blacoste.bsky.social · 1d

An important advance in vascular biology!! #endothelium #vascular

Soluble guanylyl cyclase, the NO receptor, drives vasorelaxation via endothelial S-nitrosation | PNAS

We previously demonstrated that the NO-stimulated soluble guanylyl cyclase (GC1), which produces cGMP, also has the ability to transfer S-nitrosoth...

www.pnas.org

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Baptiste Lacoste @blacoste.bsky.social · 2d

Thanks again Yao Yao for the kind invite to USF! Super fun visit, I learned a lot from you and your colleagues 🙏🙏

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Baptiste Lacoste @blacoste.bsky.social · 10d

Interested in assessing #BBB integrity at high resolution in 3D by electron tomography without spending $$$$$ on cryo-EM? I think we can help with this detailed method 😇 #cerebrovascular #microscopy #EM

Volumetric Analysis of the Blood–Brain Barrier After Ischemic Stroke by Electron Tomography in Mice

Objective Transmission electron microscopy (TEM) enables ultrastructural investigation of both organic and nonorganic samples. However, conventional TEM is limited by the acquisition of two-dimensio...

onlinelibrary.wiley.com

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Baptiste Lacoste @blacoste.bsky.social · 13d

Good question but that remains to be tested 😇

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Baptiste Lacoste @blacoste.bsky.social · 13d

Very proud to have Bernard’s team in our Program!

Baptiste Lacoste @blacoste.bsky.social · 15d

Acetaminophen, not acedow-manophin

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Baptiste Lacoste @blacoste.bsky.social · 17d

I would prefer “may not be” or “do not seem to be” 😇

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Baptiste Lacoste @blacoste.bsky.social · 17d

Freedom of speech on X, not on Jimmy Kimmel

Baptiste Lacoste @blacoste.bsky.social · 26d

Very cool new paper from @caglaeroglu.bsky.social's lab showing the mitochondria dynamics regulate astroglial morphogenesis! doi.org/10.1083/jcb.... #Astrocytes #Development

Mitochondrial fission controls astrocyte morphogenesis and organization in the cortex | Journal of Cell Biology | Rockefeller University Press

During cortical astrocyte morphogenesis, mitochondria fragment and decrease in size to populate distal astrocyte processes. Drp1-mediated mitochondrial fis

doi.org

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Baptiste Lacoste @blacoste.bsky.social · Sep 7

New work establishing a key role for FOXQ1 in the regulation of brain endothelial metabolism. #Cerebrovascular

FOXQ1 Regulates Brain Endothelial Mitochondrial Function by Orchestrating Calcium Signaling and Cristae Morphology

FOXQ1 emerges as a master transcriptional regulator of brain endothelial metabolism, orchestrating mitochondrial function through dual control of calcium signaling and cristae organization. This stud...

doi.org

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Baptiste Lacoste @blacoste.bsky.social · Sep 3

#Pericyte #Endothelium #Angiogenesis

CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment

Endothelial cell (EC)-pericyte interactions are known to remodel in response to hemodynamic forces, yet there is a lack of mechanistic understanding of the signaling pathways that underlie these event...

www.biorxiv.org

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Baptiste Lacoste @blacoste.bsky.social · Sep 2

The type of stuff I like (not biased at all...) #Cerebrovascular #autism #Development

Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia - Molecular Psychiatry

Molecular Psychiatry - Reviewing vascular influences on neuronal migration, cortical development, and neurodevelopmental disorders: focus on autism, ADHD and schizophrenia

doi.org

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Baptiste Lacoste @blacoste.bsky.social · Aug 31

#cerebrovascular #SmallVesselDisease

Cerebrovascular p16INK4A expression induces cerebral small vessel disease-related phenotypes - Acta Neuropathologica Communications

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive impairment and dementia (VCID) and highly associated with Alzheimer’s disease pathogenesis. There is an urgent need ...

doi.org

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Baptiste Lacoste @blacoste.bsky.social · Aug 31

I hope he gets what he deserves

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Baptiste Lacoste @blacoste.bsky.social · Aug 31

Génial!

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Baptiste Lacoste @blacoste.bsky.social · Aug 28

New paper by Philippe Monnier's team: Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke @natureportfolio.nature.com #Stroke #BBB #cerebrovascular

Inhibition of proprotein convertase SKI-1 prevents blood vessel alteration after stroke - Nature Cardiovascular Research

Shabanzadeh et al. identify and validate a pathway whereby RGMa cleavage by SKI-1 modifies gene expression related to blood–brain barrier (BBB) integrity after stroke. SKI-1 inhibition restores BBB in...

www.nature.com

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Baptiste Lacoste @blacoste.bsky.social · Aug 26

Patience

Baptiste Lacoste @blacoste.bsky.social · Aug 23

Absolutely fascinating science and interactions with families here at the 2025 Synchrony Symposium on #autism in Monterey! A wonderful gathering organized by the Brain Foundation. #TranslationalScience

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Baptiste Lacoste @blacoste.bsky.social · Aug 21

Celebrating all things is a healthy philosophy!

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Baptiste Lacoste @blacoste.bsky.social · Aug 19

Thrilled to be listed as invited speaker for @harvardmed.bsky.social's Neurobiology seminar series in December! Please come if you are around 😊. I'll share the whole neurovascular story about neurodevelopmental disorders #ASD #cerebrovascular #seminar

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Baptiste Lacoste @blacoste.bsky.social · Aug 14

#development #metabolism 👇👇

Stylianos Lefkopoulos (he/him) @slefkopoulos.bsky.social · Aug 13

Anyone here interested in #metabolism in #devbio ?
We recently published a Review article by Jin Zhang & co discussing the relationship between metabolism and #embryogenesis. Enjoy the read! :D
👉https://rdcu.be/eADIT
www.nature.com/articles/s41...

Metabolic regulation of key developmental events during mammalian embryogenesis - Nature Cell Biology

This Review discusses the intricate relationship between metabolism and embryogenesis, highlighting the orchestration of key developmental processes by metabolites and signalling molecules that provid...

www.nature.com

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Baptiste Lacoste @blacoste.bsky.social · Aug 12

Another beautiful study by the lab of @andyshihlab.bsky.social published today in @natureportfolio.nature.com 👏🏻👏🏻👏🏻 #cerebrovascular #aging

Impaired capillary–venous drainage contributes to gliosis and demyelination in mouse white matter during aging - Nature Neuroscience

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...

doi.org

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Baptiste Lacoste @blacoste.bsky.social · Aug 11

Really cool stuff on #pericytes @natureportfolio.nature.com !

Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy - Nature Biomedical Engineering

An optimized pipeline for functional ultrasound localization microscopy is safely and non-invasively applied to detect and characterize early microvascular alterations with high spatial and temporal r...

www.nature.com

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Baptiste Lacoste @blacoste.bsky.social · Aug 1

It’s been a long while since I posted an #astrophotography image, but from my vacation in France I have access to clear and deep skies! Below is the heart of M16, and its famous “Pillars of Creation”.🤩

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Baptiste Lacoste @blacoste.bsky.social · Jul 25

Congrats on a new amazing story!

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